Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"neural precursor cell"”.
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Merlin Regulation of Mouse Spinal Cord Neural Precursor Cell Function
… neoplasms, the majority of which are glial cell tumors (ependymoma and astrocytoma) thought to arise from multipotent neuroglial progenitor (stem) cells (NPCs) within the spinal cord. Whereas many spinal ependymomas exhibit indolent behavior, the only treatment option for …
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Mechanisms of translational control by the ubiquitin E3 ligase neural precursor cell expressed developmentally down-regulated gene 4-like, Nedd4-2
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-05-01
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Evolutionary analysis and functional characterization of the forkhead transcription factor FoxG1
… maintains the population of cortical progenitor cells by promoting their proliferation and inhibiting differrentiation. Vertebrate FoxG1 orthologs have highly conserved DNA-binding and corbosy-terminal domains that have functional roles. Conversely, no functional role has yet been assigned to the …
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P107 negatively regulates the neural precursor pool by repressing Hes1 transcription
Stem cells are defined by their multipotentiality and their long-term ability to self-renew. P107, a member of the pocket protein family of cell cycle regulators has previously been shown in our laboratory to negatively regulate neural precursor cell number and self-renewal (Vanderluit et al., …
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An Examination of the Long-lasting Effects of Lipopolysaccharide-induced Sepsis on Cognitive and Affective Behaviour in Mice
… the post-septic hippocampus and amygdala such as neural precursor cell production and the production of proteins important to long-term potentiation. In order to investigate whether pharmacological intervention could ameliorate these post-septic changes NF-κB inhibitor pyrrolidine dithiocarbamate …
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Effect of Nedd4 Haploinsufficiency on Insulin Sensitivity, Adiposity and Neuronal Behaviors
<p>The neural precursor cell expressed developmentally down-regulated gene 4 (NEDD4) is a HECT-type E3 ubiquitin ligase that has received broad attention in recent years. Many of its reported substrates are active players in metabolism, implying a potential role of NEDD4 itself in metabolic …
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Genetic Factors and Dietary Salt Intake as Determinants of Blood Pressure and Risk of Primary Hypertension
… regulated kinase 1 gene (SGK-1)) or both (Neural precursor cell Expressed Developmentally Down regulated 4 like gene (NEDD4L)) (study III-V); (iii) investigate the role of dietary salt restriction on BP as well as to explore the possibility to predict this BP change by measuring plasma …
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The role of Ubiquitin ligases Nedd4-1 and Nedd4-2 in the brain and their crosstalk with alpha-synuclein and other dementia-related proteins
… nigra (SN) dopaminergic neurons, causing cell death. Current PD and DLB treatments are symptomatic and do not target the disease at its source or prevent its progression.<br/>In order to develop protective treatments for PD and DLB, it is important to first understand its pathophysiology. …
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Assessing Epidermal Growth Factor Expression in the Rodent Hippocampus Following Traumatic Brain Injury
… injury. Research indicates that proliferation of neural precursor cells increases following brain injury, which implies that there is an endogenous response in the hippocampus to replenish neurons and restore cognitive function. Studies show that mitogenic growth factors may drive this …
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The regulation of neuronal excitability by epilepsy-associated gene Nedd4-2
… with epilepsy. Among those genes identified, the neural precursor cell expressed developmentally down-regulated gene 4-2, Nedd4-2, was specifically noted. Furthermore, three missense changes in Nedd4-2 have also been identified in families with epilepsy. Nedd4-2 gene encodes a ubiquitin E3 ligase …