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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"neural differentiation"”.
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Mesenchymal stem cells as trophic mediators of neural differentiation
… by which MSCs commit to a given fate and undergo differentiation to produce mature, fully-functional derivatives. Much of our present knowledge is derived from studies performed on the highly unnatural, 2D environment of tissue culture plastic. The present study assessed the behaviour of MSCs …
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TWIST1: a subtle modulator of neural differentiation and neural tube formation
… epiblast precursor cells through Neurulation. Neural induction can be studied in its main aspects in vitro. However, the process is poorly understood, especially in regard to when and how a cell becomes specified, and then committed, to be a neural cell. It is, on the other hand, well …
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Regulation of polycomb repressive complexes at the neural differentiation gene Pax6
During body axis elongation spinal cord neural tissue in the posterior of the embryo is progressively generated from a pool of bipotent progenitors of the stem zone/caudal lateral epiblast, termed neuromesodermal progenitors. Neural differentiation gene transcription begins in a sharply defined …
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Inhibitory Control of Neural Differentiation in Explants of Rana Pipiens Gastrula Ectoderm
Made available in DSpace on 2014-12-04T22:46:13Z (GMT). No. of bitstreams: 1 6003902.pdf: 2144297 bytes, checksum: 284a504d8631cde70d658a32de811242 (MD5) Previous issue date: 1960
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Neural differentiation of pluripotent stem cells and applications to micropatterned agarose hydrogel for nerve guidance
… hedgehog (shh) agonist, and glucose levels on neural differentiation of mouse embryonic stem cells (mESCs), and (2) to employ micropatterned agarose hydrogels for nerve guidance. A protocol utilizing embryoid body (EB) formation, under both high and low glucose conditions, was devised for …
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In vitro evaluation of human mesenchymal stem cell neural differentiation on tyrsine-derived polyarylates and polycarbonates
… can return in the hopes of repairing the neural cells with a tissue engineered designed scaffold complex. The scaffold complex will include cells to repair and replace the damaged cells. Mesenchymal stem cells (MSC) are multipotent adult stem ells that are capable of differentiating along …
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ADULT HUMAN BRAIN MENINGES HOST NEURAL STEM/PRECURSOR CELLS THAT CAN BE IN VITRO EXPANDED AND SHOW MULTIPOTENT NEURAL DIFFERENTIATION POTENTIAL IN 2D AND 3D CULTURE
… the multipotent, self-renewing and proliferating neural stem/progenitor cells (NSCs) through the processes like neurogenesis and gliogenesis [1]. In the developed mammalian brain these NSCs have been found to be restricted to limited regions called neurogenic niches [2]. These neurogenic niches …
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Engineering biomaterial surfaces with N-cadherin
… tissues. It plays a significant role in neural development, regeneration, and pathological processes. Recently, efforts were increasingly made to better understand biological function of N-cadherin and further harness it in the assembly of biomedical devices used for sensing, diagnosis, …
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Investigating the role and regulation of mRNA capping in pluripotency and differentiation
… RAM maintain expression of pluripotency factors. Differentiation of mESCs to neural progenitors is accompanied by a suppression of RAM, resulting in downregulation of pluripotency factors and efficient formation of neural cells.<br/><br/>Here, I demonstrated that the suppression of RAM during …
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NEURAL CORRELATES OF RANDOM AND INFORMED SACCADIC CHOICES IN THE MACAQUE FRONTAL EYE FIELDS AND CENTRAL THALAMUS
… may contribute to saccade target selection, neural correlates of perceptual judgment and motor choice were evaluated for visuomotor neurons recorded in the FEF and OcTh. Monkeys performed a compelled-saccade task, a two-alternative forced-choice task that requires rapid perceptual judgments …
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Neural stem cell differentiation in collagen scaffolds for retinal tissue engineering
Rat neural stem cells (NSCs) were cultured in monolayer or in porous collagen scaffolds and exposed to neurogenic or non-neurogenic medium to determine the effects on neural differentiation and neurite growth. Nestin, [beta]III-tubulin, and GFAP expression were determined using immunofluorescent …
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Investigating the Role of the mRNA Capping Enzymes in Mouse Embryonic Stem Cells and Differentiation
… in a positive feedback loop manner. During neural differentiation, RAM is degraded in an ERK1/2-dependent manner.<br/><br/>This work focused on further investigating the role of the mRNA capping enzymes in pluripotency and differentiation. CMTR1, the first nucleotide O-2 ribose …
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Developmental Regulation of Prion Expression in Cattle and Mouse Embryonic Stem Cells
… have suggested the participation of PrPC in neural stem/progenitor cell proliferation and differentiation. The first objective in our study was to map the expression of PrPC in twenty six somatic and reproductive tissues in ruminants. Our second objective was to characterize the ontogeny of …
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Recording Transcription Factor Binding During Development
… events of the transcription factor Olig2 during neural differentiation. In summary, this dissertation presents a useful method for recording transcription factor binding during development.</p>
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Genetic regulation of neuronal stem cell differentiation: a single-cell sequencing study in planarians
… However, the genetic networks that drive the differentiation of planarian adult stem cells into the neural lineage are still unknown. Here we show that single-cell expression profiling technologies allow disentangling neuronal heterogeneity to investigate the complexity of nervous system …
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Engineered N-cadherin substrates for stem cell differentiation
… tissues. Certain success was made to modulate neural differentiation of stem cells using soluble factors and cell adhesion matrix properties. These differentiation studies are often dependent on the density of cells plated on the substrate, which implies that there is an important role of …
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Alginate-based Hydrogels for Central Nervous System Tissue Regeneration
… allow three-dimensional cultures for stem cells differentiation and are helpful in order to obtain cells at the right developmental stage for transplantation. Moreover, they could help to enhance and control cell survival after transplantation, minimizing cell death. Stroke is a very severe form …
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O-linked N-acetylglucosamine in differentiation and gene expression of mouse and human pluripotent stem cells
… of O-GlcNAc hydrolase (Oga) hinder mouse ES cell differentiation. In addition to these findings, I could also demonstrate that increased O-GlcNAcylation leads to expression of a gene set normally epigenetically repressed in mouse ES cells and associated with a subpopulation resembling cells in the …
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Temporal evolution of intracellular signaling and gene expression following patterns of membrane depolarization in the pheochromocytoma cell line, PC 12
… by electrical activity. These genes included neural differentiation-specific genes, as well as genes involved in cell cycle control and intracellular signaling.
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