Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 90 for “"neural development"”.
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The Neural Development of Visuohaptic Object Processing
… currently a paucity of research surrounding the neural development of visuohaptic processing in children. Little is known about how and when vision converges with haptics for object recognition. In this dissertation, I investigate the development of neural mechanisms involved in multisensory …
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Investigating the role of Neuronatin in neural development
Neural induction is the process that occurs during embryogenesis whereby ectoderm is converted into neural tissue. However, the cellular and molecular mechanisms that govern this process are still not completely understood. For instance, in Xenopus, calcium signalling is known to play a pivotal …
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Genetic and Environmental Influences on Cognitive and Neural Development
… relationships, and how they relate to human development. Using multiple data types from the Avon Longitudinal Study of Parents and Children (ALSPAC) combined with a diverse methodological approach, I highlight compounding environmental factors which longitudinally interact to predict …
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Interaction between form and fate during human neural development
… the interaction between shape and fate during neural development. We relied on cerebral organoids as a tractable *in vitro* system where tissue shape can be manipulated following several complementary approaches and tissue identity assessed by transcriptomics. We first discovered key protocol …
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Neural Development to Neurodegeneration Through the Mind of a Worm
… organism. By examining mutations during neuronal development, we can better understand the significance of specific pathways. The EphR/ephrin pathway is crucial for axonal guidance during development. The simple organism, <em>C. elegans</em>, allow us to study the impact of EphR/ephrin genes on …
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Probabilistic Dynamical Modelling of Spatiotemporal Cell Trajectories During Neural Development
… to more effectively map the rules of brain cell development in health and disease. Cell2fate is an RNA velocity model for inference of transcriptional dynamics from spliced and unspliced RNA counts. Unlike existing models, cell2fate is capable of capturing complex biological processes while still …
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Transgenic approaches to the study of neural development in mice
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.
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Analysis of the Mechanisms and Principles of Neural Development in the Drosophila
… possible principles that are applied to synaptic development. By systematically examining individual neuromuscular synapse in Drosophila, I observed key features of synaptic formation. Examining the motoneurons that formed different types of boutons showed variances in the innervation patterns …
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Co-factors of LIM-HD transcription factors in neural development and axon pathfinding in zebrafish
… system is an elegant model to study neural development. To reveal a specific programme for zebrafish motor axon pathfinding I established a method to selectively block motor axon pathfinding by interfering with LIM domain transcription factor signaling. LIM homeodomain proteins …
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Effect of rearing environment and environmental enrichment on behavior and neural development in young pigs
There is increasing concern about the welfare of farm animals. In two trials, forty-eight 7.97 and 10.78 kg Hampshire-sired crossbred pigs were housed in either a complex environment (CE) or a simple environment (SE) for 9.5 weeks. The SE consisted of two pigs, in 1.22 x 1.22-m pens in a closed …
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MacMARCKS and the Protein Kinase C Signal Transduction Pathway: Role in Neural Secretion and Neural Development
… diverse roles for MacMARCKS ranging from neural secretion to neural development. Chapters 3 and 4 describe the role of MacMARCKS in neural secretion. MacMARCKS is phosphorylated in a stimulus-dependent manner in rat brain synaptosomes and PC12 cells. It is localized to cell bodies and …
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Using single cell transcriptomics to uncover mechanisms of neural development, neural stem cell quiescence and tumourigenesis
Neural stem cells produce all the cells of the nervous system and regulation of proliferative behaviour is crucial for proper brain development. Over-proliferation of NSCs can also lead to disease, resulting in the formation of tumours. There is a delicate balance between NSC proliferation, …
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Impacts of developmental exposures to the harmful algal bloom toxin domoic acid on neural development and behavior
… life can lead to long-term changes in behavior, neural connectivity, and brain morphology. To determine the underlying mechanisms of developmental toxicity, this dissertation used zebrafish as a tool to: i) Establish the developmental window of susceptibility for DomA toxicity, ii) Characterize …
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Light Sheet Microscopy and Image Analysis of Neural Development and Programmed Cell Death in C. Elegans Embryos
… cell groups in creating these structures. New developments in microscopy have made this an excellent time to study neural development in the C. elegans embryo. In the past decade, implementations of highly light efficient methods such as single plane illumination microscopy have rendered it …
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Impacts of developmental exposures to the harmful algal bloom toxin domoic acid on neural development and behavior
… life can lead to long-term changes in behavior, neural connectivity, and brain morphology. To determine the underlying mechanisms of developmental toxicity, this dissertation used zebrafish as a tool to: i) Establish the developmental window of susceptibility for DomA toxicity, ii) Characterize …
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The Effects of Prenatally Induced Hypothyroidism of the Neural Development and Problem Solving Ability of Maturing Hypothyroid Rats
… of hypothyroid rats show differences in the development of the cerebellum as evidenced by histological examination. Recommendations. Further study with smaller blocks of tissue, electron microscopy, and a different method of tissue preparation should yield data on subcellular changes of …
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The Characterization Of Pb2+ Toxicity In Rat Neural Development: An Assessment Of Pb2+ Effects On The Gaba Shift In Neural Networks And Implications For Learning And Memory Disruption
… system has been investigated to assess early developmental GABAergic disruption and its implications with altering inhibitory learning and memory. This goal was achieved using a multi-systems approach: blood lead levels (clinical physiology), qRT-PCR (molecular genetics), brain and primary …
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Sox2 co-occupies distal enhancer elements with cell-type-specific POU factors to specify cell identity in embryonic stem cells and neural precursor cells
… embryonic stem cells (ESCs) and multipotent neural progenitor cells (NPCs), but what common or distinct roles Sox2 may play in these cell types not fully understood. Further, the molecular mechanisms by which Sox2 can specify two distinct cell identities are as of yet unclear. This thesis is …
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The Nrg Growth Factors and Their Receptor ErbB4 in the Developing Brain: Delineation of Nrg3 Expression and Neuritogenesis
… making it repeatedly vulnerable to possible developmental abnormalities that can endure into adulthood. The neuregulin (Nrg) family of growth factors (Nrg1-4) and their receptor, ErbB4, have been linked to mental illnesses considered to emerge as a result of abnormal neural development, such …
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