Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 46 for “"neural crest cells"”.
-
Transcriptional profiles of differentiating periocular neural crest cells and the function of Nephronectin during chick corneal development
During eye formation, periocular neural crest cells (pNC) migrate and differentiate to form the anterior ocular structures. In the chick cornea, this involves two waves of migration that result in the formation of the corneal endothelium and stroma. Abnormalities in pNC migration lead to corneal …
-
Identification of the Molecular Basis of Morphological Variation in Avian Beaks
… morphology in craniofacial structures. Cranial neural crest cells give rise to all the cartilage and bone of the face, and transplantation experiments have shown that these cells contain species-specific patterning information. First, I employed custom cross-species microarrays to analyze the …
-
Transcriptional Regulation of Neural Crest-Derived Pharyngeal Arch Artery Development
… process requires contribution from specialized neural crest cells, which originate in the neural folds and migrate to give rise to specific segments of the great vessels as well as particular facial structures. Many syndromic birth defects in humans affecting the heart and face arise as a result …
-
Transcriptional Regulation of Neural Crest-Derived Pharyngeal Arch Artery Development
… process requires contribution from specialized neural crest cells, which originate in the neural folds and migrate to give rise to specific segments of the great vessels as well as particular facial structures. Many syndromic birth defects in humans affecting the heart and face arise as a result …
-
Nkx3.2 regulates zebrafish vascular stabilization through recruitment of mural cells
… recruitment and adhesion of perivascular mural cells; pericytes and vascular smooth muscle cells (vSMC). When vessels are not well supported by mural cells hemorrhage can occur. Nkx3.2 deficient zebrafish embryos hemorrhage, have reduced expression of a mural cell marker, and the endothelial …
-
REGULATION OF NEURAL CREST DEVELOPMENT REQUIRES FUNCTIONAL INTERACTIONS BETWEEN HDAC1, TFAP2A AND FOXD3
The neural crest (NC) is a transient embryonic cell population that diversifes into a wide variety of cell types including glia and neurons of the peripheral neurvous system, pigment cells and elements of the craniofacial skeleton. However, the mechanisms regulating the process of neural crest cell …
-
IDENTIFICATION OF KEY MOLECULES IN PLACODE-DERIVED NEURONS THAT COORDINATE CHICK TRIGEMINAL GANGLIOGENESIS
… ganglion, which arises from the coalescence of neural crest cells and placode cells. These progenitor cells give rise to trigeminal sensory neurons, with placode cell differentiation occurring first. While the dual cellular origin of the trigeminal ganglion has been known for decades, the …
-
MyosinX is Required For Craniofacial Development in Danio Rerio
… bone structures are almost entirely derived from neural crest cells. Neural crest are a pluripotent migratory stream of cells that originate from the early developing brain and settle in final positions that give rise to the future skull and face. Several motor proteins are implicated in the …
-
Birds of a white feather : a congenital hypopigmentary disorder in the chick
… melanise. To address this issue, black and white neural crest cells were cultured in conditions resembling their respective skin environments. Firstly, black neural crest cells grown in defined medium with either black or white skin extract were able to synthesise melanin. This suggests that white …
-
The Role of MicroRNAs in Craniofacial Development
… to defects seen as a result of aberrant cranial neural crest cell migration and differentiation. Sox9 is a molecular marker of cranial neural crest cells and participates in their maintenance and ability to respond to chemotactic signals during migration. Investigation of Sox9 expression, between …
-
ONTOGENESIS OF MURINE NEURAL CREST DERIVATIVES
The neural crest is an epithelial domain within the neural and non-neural ectoderm. This domain is generated along the anterior-posterior axis-giving rise to many different cell types. The key difference between cranial and trunk neural crest is the ability of cranial neural crest to give rise to …
-
The extreme anterior domain coordinates brain and craniofacial development
… Extreme Anterior Domain (EAD), a group of 500 cells located at the anterior tip of the frog embryo, coordinates brain and craniofacial development through two distinct mechanisms. First, the EAD acts as a long range organizer for head development by regulating the size of both the brain and …
-
Hdac3 is a Critical Regulator of Neural Crest Progenitor Cell Biology
… undescribed role of Hdac3 in regulating neural crest progenitor cell behavior. By genetically deleting Hdac3 in premigratory neural crest cells, I use in vivo and ex vivo techniques to show that Hdac3 plays crucial roles in multiple facets of neural crest development, and that …
-
Hypomelanosis in chickens
… were conflicting: 1) In culture, white chick neural crest cells produced pigment, suggesting that the melanocyte is not defective. However, ultrastructural examination of these cultured melanocytes showed that they contained a large proportion of partially melanised melanosomes. 2) Black chick …
-
Problems in hard and soft matter: From brain folds and Levy localization to active elasticity
… tissue, which is composed of neurons, glial cells, and progenitor cells, we model an experiment (Theveneau) studying the dynamic interaction between neural crest cells and placodal cells in which the placodal cells run away from the neural crest cells following contact between the two. Our …
-
Identification of a Novel Role of BMP Signaling in Enteric Neural Crest Colonization of the Zebrafish Enteric Nervous System
… development following the migration of enteric neural crest cells (ENCCs) into the primitive gut tube. Much work has been done to unravel the complex nature of extrinsic and intrinsic factors that regulate the processes that direct the migration, proliferation, and differentiation of the ENCCs. …
-
Transcriptional Elongation is Important for Neural Crest Development
Neural crest cells are a multipotent cell population, which migrate from the dorsal neural tube in early vertebrate development throughout the embryo to form a variety of cell types including pigment cells, craniofacial cartilage and sensory neurons [1, 2]. Here I show that the small molecule …
Page 1 of 3