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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 105 for “"neural crest"”.
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ONTOGENESIS OF MURINE NEURAL CREST DERIVATIVES
The neural crest is an epithelial domain within the neural and non-neural ectoderm. This domain is generated along the anterior-posterior axis-giving rise to many different cell types. The key difference between cranial and trunk neural crest is the ability of cranial neural crest to give rise to …
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Transcriptional Elongation is Important for Neural Crest Development
Neural crest cells are a multipotent cell population, which migrate from the dorsal neural tube in early vertebrate development throughout the embryo to form a variety of cell types including pigment cells, craniofacial cartilage and sensory neurons [1, 2]. Here I show that the small molecule …
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Effects of Homocysteine on Cardiac Neural Crest Cell Formation
… of congenital detects, many of which resemble neural crest (NC) cell ablation. However, the etiological mechanism is not known. The purpose of this study was to determine if Hcys altered the number and/or the proliferation of NC cells or their progenitors /?? Uw. Hcys was experimentally …
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Transcriptional Regulation of Neural Crest-Derived Pharyngeal Arch Artery Development
… process requires contribution from specialized neural crest cells, which originate in the neural folds and migrate to give rise to specific segments of the great vessels as well as particular facial structures. Many syndromic birth defects in humans affecting the heart and face arise as a result …
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Transcriptional Regulation of Neural Crest-Derived Pharyngeal Arch Artery Development
… process requires contribution from specialized neural crest cells, which originate in the neural folds and migrate to give rise to specific segments of the great vessels as well as particular facial structures. Many syndromic birth defects in humans affecting the heart and face arise as a result …
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Deciphering the regulatory code driving neural crest evolution and development
Neural crest cells are a unique feature of vertebrates. This embryonic cell population is multipotent, giving rise to many structures including peripheral neurons. The sea lamprey, Petromyzon marinus, is at the base of the vertebrate lineage and offers an ideal model for the ancestral neural crest. …
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Yap and Taz Are Required For Neural Crest-Derived Cardiovascular Development
… a leading cause of early infant death. Cardiac neural crest cells (NCCs) are a migratory and multipotent cell population known to aid in the development of the cardiac outflow tract (OFT), valves, and interventricular septum, during embryogenesis. <em>Yap </em>and <em>Taz </em>are downstream …
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Hdac3 is a Critical Regulator of Neural Crest Progenitor Cell Biology
… undescribed role of Hdac3 in regulating neural crest progenitor cell behavior. By genetically deleting Hdac3 in premigratory neural crest cells, I use in vivo and ex vivo techniques to show that Hdac3 plays crucial roles in multiple facets of neural crest development, and that …
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Med12 Is A Critical Regulator of Neural Crest Lineage and Nervous System Myelination
… of Med12, with a special emphasis on cells of neural crest origin. Moreover, our models constitute versatile <em>in vivo</em> tools for future studies by reliably modeling a variety of pathologies presented in multiple neurological syndromes, including but not limited to developmental …
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REGULATION OF NEURAL CREST DEVELOPMENT REQUIRES FUNCTIONAL INTERACTIONS BETWEEN HDAC1, TFAP2A AND FOXD3
The neural crest (NC) is a transient embryonic cell population that diversifes into a wide variety of cell types including glia and neurons of the peripheral neurvous system, pigment cells and elements of the craniofacial skeleton. However, the mechanisms regulating the process of neural crest cell …
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Arid1a Haploinsufficiency Initiates Neural Crest Transformation in a Mouse Model of Mycn-driven Neuroblastoma
… freshly isolated embryonic day 9.5 primary trunk neural crest cells (NCCs), Arid1a was heterozygously and homozygously deleted in combination with Mycn overexpression. We injected these genetically modified primary cells into mice to determine if Arid1a loss collaborates with Mycn overexpression …
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Variation in neural crest development contributes to phenotypic diversification of East African cichlid fishes
… migratory progenitor cell population, the neural crest (NC). Although the genetic and developmental basis of these phenotypes has been investigated, understanding of how and when, specifically how early, in ontogeny species-specific differences emerge, remains limited. In this PhD thesis, I …
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RDH10 is Necessary for Initial Vagal Neural Crest Cell Contribution to Embryonic Gastrointestinal Tract Development
… the gastrointestinal tract due to a failure of neural crest cell (NCC) colonization or development, leading to megacolon and/or the failure to pass meconium. Enteric neurons are derived from neural crest cells (NCC); hence HSCR is associated with incomplete NCC development or colonization of the …
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Molecular Basis and Modification of a Neural Crest Deficit in a Down Syndrome Mouse Model
… in Ts65Dn mice can be traced back to an original neural crest cell (NCc) deficit in the developing first pharyngeal arch (PA1) at embryonic day 9.5 (E9.5). Furthermore, evidence suggested that both a proliferation deficit in the PA1 and a migration deficit in the NCC from the neural tube (NT) …
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Adipose-Derived Stromal Cells Contribute To Spinal Cord Repair But Are Not Neural-Crest Derived Stem Cells
… and are easily harvested and cultured in vitro. Neural crest derived tissues have the extraordinary capacity to give rise to a wide range of tissue types: neurons and glia of the peripheral nervous system, adrenal glands, chondrocytes and osteocytes of the head and neck, smooth muscle cells of …
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Transcriptional profiles of differentiating periocular neural crest cells and the function of Nephronectin during chick corneal development
During eye formation, periocular neural crest cells (pNC) migrate and differentiate to form the anterior ocular structures. In the chick cornea, this involves two waves of migration that result in the formation of the corneal endothelium and stroma. Abnormalities in pNC migration lead to corneal …
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Quantitative analysis of the effect of leflunomide on neural crest cell gene regulation during early embryonic development
The neural crest is a transient population of cells that arises at the border between the neural and non-neural ectoderm. These cells are induced, undergo an epithelial-to-mesenchymal transition, and then migrate along stereotypical pathways to form an array of derivatives such as pigment cells, …
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