Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 76 for “"neural circuit"”.
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Neural Circuit Mechanisms Underlying Behavioral Evolution in Drosophila
… mechanisms and diversification of central circuitry and suggest how evolution can exploit flexible circuit nodes to generate behavioral variation. To investigate if changes in the balance of excitation and inhibition at this node evolved repeatedly, we began characterizing the pheromone …
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Mechanisms underlying neural circuit remodeling in Toxoplasma gondii infection
… my dissertation, I investigate the telencephalic neural circuit changes induced by long-term Toxoplasma infection in the mouse brain and the neuroimmune signaling role of the complement system in mediating microglial remodeling of neural circuits following parasitic infection. While there has been …
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Neural Circuit Dependence of Acute and Subacute Nociception in C. Elegans
… elegans shares many features of the mammalian circuit. Both neural circuits feature a direct path from sensory neurons to motor neurons that is connected by a single class of interneuron, bypassing the higher processing centers. Both neural circuits also feature higher processing pathways that …
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Generation and tuning of learned sensorimotor behavior by multiple neural circuit architectures
… and tune these motor responses, and are certain circuit architectures, or connectivity patterns, optimally suited for certain sensorimotor applications? This thesis presents progress towards this particular problem in three subprojects. The first section re-analyzes a large data set of …
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Molecular tuning of a neural circuit that drives aggregation behaviour in C. elegans
… understanding the physiological flexibility of neural circuits is linking molecules that regulate behaviour to changes in the properties of individual neurons. Here, we use a defined neural circuit in C. elegans to frame this universal problem. By genetic dissection of the behavioural state that …
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Genetic and Neural Circuit Analyses of Sickness and Foraging Behaviors in C. elegans
… generates behaviors. Neuromodulation of brain circuits is thought to be critical for animals to generate long-lasting behavioral states crucial for survival. However, our understanding of the specific mechanisms by which neuromodulators alter circuit function to drive context-relevant and …
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The Neural Circuit for Behavioral Responses to Pheromone and Social Behavior in Caenorhabditis Elegans
… and has been studied at both molecular and circuit levels. However, the central issue of how genes and molecular components contribute to neural circuits that eventually lead to complex social behaviors remains unclear. Using the nematode model organism Caenorhabditis elegans, I have …
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The Role of Gene Regulation in Neural Circuit Development: Studies in the Zebra Finch
… and production are controlled by the brain song circuit which consists of auditory and motor pathways. The purpose of this thesis is to study genomic mechanisms underlying zebra finch song circuit formation. First, the expression of genes encoding synaptic proteins was measured by in situ …
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An optimization approach to relate neural circuit architecture, loss landscapes and learning performance in static and dynamic tasks
Learning is challenging for large and complex neural circuits. There is a fundamental difficulty in determining how individual neurons or synapses affect the overall behavior of a circuit, which is known as the credit assignment problem. Rather than looking at single neurons or synapses then, one …
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The development of functional inputs to a neural circuit : synaptic strength before and after the activity-dependent maturation of the retinogeniculate system
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 1999.
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Augmenting Wiring Diagrams of Neural Circuits with Activity in Larval Drosophila
Neural circuit models explain an animal's behavior as evoked activity of different circuit elements of its nervous system. Synaptic wiring diagrams mapped from structural imaging of nervous systems guide modeling of neural circuits on the basis of connectivity. However, connectivity alone may not …
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Interazione dopamina-ossitocina nel controllo centrale della risposta erettile
… The results obtained suggest the existence of a neural circuit where dopaminergic and oxytocinergic neurons play a key role in the motivational/rewarding and consummatory aspects of male sexual behavior. When activated, this circuit facilitates not only the copulatory behavior through the …
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Design of an Embedded Fluorescence Imaging System for Implantable Optical Neural Recording
… tive on the study of the functional brain at a neural circuit level, enabling in-depth understanding of both physiological processes and animal models of neurological and psychiatric diseases which currently lack e↵ective treatments. These new tools come at the cost of meeting the challenges …
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Mapping the Spatial Transcriptome Across Whole Organisms
… data with in situ connectomics and in vivo neural activity recordings. Understanding the spatial transcriptome in C. elegans is vital for insights into neural circuit coordination, disease mechanisms, and developmental biology.
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Autonomous Flight Arcade: Reinforcement Learning for End-to-End Control of Fixed-Wing Aircraft
… policies can be learned through the Neural Circuit Policy architecture on these environments. Finally, we present baselines of both human and AI performance on the Autonomous Flight Arcade environments.
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Estrogen Signaling in the Ventromedial Hypothalamus Modulates Adipose Tissue Metabolic Adaptation
… We previously showed that an ERαvlVMH-originated neural circuit responds to changes in ambient temperature and nutritional states, suggesting a potential role of this neural circuit in metabolic adaptation. Here, we found that chronic activation of ERαvlVMH neurons prevents diet-induced obesity …
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Cortical - Basal Ganglia Circuits: Control of Behaviour and Alcohol Misuse
Highly organised and differentiated neural circuits form and unite to link the cortex with the basal ganglia and thalamus to mediate movement, cognition and behaviour. Previous assertions that the basal ganglia primarily acted to filter cortical information to facilitate motor outputs only have …
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Neural models of modulation frequency analysis in the auditory system
… auditory system. A biologically motivated neural model of AM processing has been developed. The first main component of the model allows for the simulation of the response properties of cochlear nucleus ideal onset units, a neuron type that is known to encode the modulation frequency of AM …
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Analysis of the swimming-to-crawling transition of Caenorhabditis elegans in viscous fluid
… been suggested to be controlled by two separate neural circuits of central pattern generators. Here we studied the locomotion of young adult C. elegans in viscous fluids ranging from 0.001-1000 Pa s to determine whether there is a sharp or continuous transition between swimming and crawling. We …
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Tracking Light-Induced Synaptic Engrams in in-vitro Neuronal Networks
… capacity to adjust their strength in reaction to neural circuit activation, facilitating the nervous system's adaptation to environmental stimuli and information storage. Despite its acknowledged significance, there remains a wealth of knowledge to be uncovered regarding the precise mechanisms …
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