Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"neural cell types"”.
-
Molecular targets of chromatin marks H3K4ME3, H3K9ME3 and H3K27ME3 in an adult germinal niche
Neural stem cells (NSCs) participate in a delicate balance between maintaining cellular identity through self-renewal and differentiating into myriad neural cell types. Understanding exactly how epigenetic mechanisms regulate this balance and the subsequent differentiation process in adult …
-
Songbird Brain Organization and its Molecular Convergence with Humans for Vocal Imitation Learning
<p>The rich diversity of neural cell populations and their specialized connections give rise to a suite of complex behaviors across vertebrates. The presence of common neural cell types may be a product of either shared ancestry through homology or parallel evolution through convergence. However, …
-
MicroRNAs in ALS: Defining Cell-Type Specific Expression, Developing Methods to Modulate MicroRNAs in vivo, and Identifying Novel Therapeutic Targets
… a GFP-tagged miRNA processing protein behind cell-type specific promoters allowed for the identification of miRNA expression patterns in various neural cell types. From this information, we focused on the role of miR-155 on glial cells and particularly on neuroinflammatory pathways in ALS. …
-
Investigating the role of Neuronatin in neural development
Neural induction is the process that occurs during embryogenesis whereby ectoderm is converted into neural tissue. However, the cellular and molecular mechanisms that govern this process are still not completely understood. For instance, in Xenopus, calcium signalling is known to play a pivotal …
-
Mash1 Defines Lineage Restricted Neuronal and Oligodendrocytic Precursor Cells in Spinal Cord Development
Recent advances have defined distinct neural progenitor and early interneuron pools in the developing spinal cord and the molecular events that influence progenitor cell fate. However, these early neurons have not been traced to adult neuron types. The transcription factor Mash1 is transiently …
-
Neoblast specialization during regeneration of the planarian S. mediterranea
… regeneration requires a population of dividing cells called neoblasts that are distributed throughout the body. Historically, neoblasts have been considered a homogeneous population of stem cells capable of differentiating into all cell types. Most studies, however, analyze neoblasts at the …
-
Generating a proteomic profile of neurogenesis, through the use of human foetal neural stem cells
… neurons, starts soon after the formation of the neural tube and is largely completed by birth. Development of the brain after birth is mainly reliant on the formation of new connections between surviving neurons. However, adult neurogenesis does continue in the subgranular zone of the hippocampus …
-
Investigating the Role of Exercise-Induced Circulating Extracellular Vesicles in Adult Myogenesis and Neurogenesis
… of specialised tissue-resident stem cells, which subsequently integrate into the existing tissue by dierentiating into mature functional cells. The molecular mechanisms regulating these processes following exercise are poorly understood to date. A possible contributing mechanism is …
-
Sensing in 3D Printed Neural Microphysiological Systems
… overall goal of producing sensor functionalized neural microphysiological systems to enable deeper fundamental understandings of disease pathology and to provide drug screening and discovery platforms for improved clinical translation. Towards this goal, work addressing three broad objectives has …
-
Transcriptional divergence during cichlid embryogenesis
… research has largely focused on diverging phenotypes of adults despite many of these variable traits likely being established during early embryogenesis. A central question that remains is how variation is generated during development. Moreover, cichlids are shown to have very low average …
-
Finding Common Ground: The Common Marmoset as a Model to Accessing and Providing Insight into the Social Brain
… we examined the hypothesis that there is a neural, functional architecture underlying face processing. Faces form a unique category of stimuli that bridge visual perception and social cognition. They are processed in dedicated areas of cortex, face patches, which are organized into an …
-
Investigating Wnt3-mediated symmetry breaking and cell fate in engineered gastruloids
… 2005). In contrast, aggregates of embryonic stem cells (ESCs) termed gastruloids are able to display symmetry breaking and develop an AP axis in the absence of extraembryonic tissues or localised exogenous positional signalling (Baillie-Johnson, van den Brink, Balayo, Turner, & Arias, 2015; …