Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 25 for “"network reconstruction"”.
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In silico bacterial gene regulatory network reconstruction from sequence
… example is in the area of gene regulatory networks. A molecular study of gene regulation proceeds one protein at a time, requiring bench scientists months of work purifying transcription factors and performing DNA footprinting studies. Massive scale options like ChIP-Seq and microarrays are …
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Metabolic network reconstruction and genome-scale model of butanol-producing strain clostridium beijerinckii ncimb 8052
Solventogenic clostridia offer a sustainable alternative to petroleum-based production of butanol—an important chemical feedstock and potential fuel additive or replacement. C. beijerinckii is an attractive microorganism for strain design to improve butanol production because it (i) naturally …
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INFERENCE OF HIDDEN HIERARCHIES FROM OBSERVABLE NETWORKS
… to infer the hierarchical organization of network systems from the observable patterns of interactions among their elements. My formulation is based on the general idea of statistical network reconstruction (Peixoto (2019a)). Current advancements in this area allowed us to infer some forms …
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Distances and Stability in Biological Network Theory
… of the algorithms for the econstruction of networks. We will focus on theory, development and implementation of operative procedures and algorithms for the assessment of stability in complex networks for biological systems, with gene regulatory networks as the key example. A major issue …
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Large, noisy, and incomplete : mathematics for modern biology
… thesis discusses two problems in this field, network reconstruction and multiple network alignment, and draws the beginnings of a connection between information theory and population genetics. The first section addresses cellular signaling network inference. A central challenge in systems …
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Decentralised network prediction and reconstruction algorithms
… study concerns the decentralised prediction and reconstruction problems in a network. First of all, we propose a decentralised prediction algorithm in the framework of network consensus problem. It allows any individual to compute the consensus value of the whole network in finite time using only …
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Integrative approaches for systematic reconstruction of regulatory circuits in mammals
The reconstruction of regulatory networks is one of the most challenging tasks in systems biology. Although some models for inferring regulatory networks can make useful predictions about the wiring and mechanisms of molecular interactions, these approaches are still limited and there is a strong …
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Valuing the ecosystem services provided by UK bats under climate change
… trait analysis, molecular dietary data, trophic network reconstruction, and economic valuation, this thesis develops a cross-scale framework linking biodiversity change to ecosystem service delivery in agricultural landscapes. First, I examined how climate and land-use change may reshape the …
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Bridging the gap between populations and individuals in the philosophy of medicine
… The third chapter focuses on so-called molecular network reconstruction, a type of mechanistic discovery strategy that leverages large datasets. While it is often difficult to find strong associations between genetic variants and individual health outcomes, this literature suggests that a higher …
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Human mitochondrial DNA and population structure of the Western Mediterranean Islands
… modern). Haplogroup assignment, phylogenetic network reconstruction, and genetic distance analyses were performed to investigate patterns of continuity, differentiation, and demographic change across the islands and within the broader Mediterranean context. The results suggest that Sardinia …
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A systems approach to identify novel ageing regulators in Caenorhabditis elegans
… objective of this study is to apply in silico network tools for the identification of novel genes which may impact the ageing process in C. elegans. Using a time-resolved transcriptomics measurements of three non-reproductive C. elegans strains, I reverse engineered Gene Regulatory Networks …
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Essays in Industrial Organization
… Chrysler's bankruptcy filing and their dealer network reconstruction, studying firms and consumers' response to this industry shock. Chapter 3 challenges the current merger policy by proposing a selective entry mechanism.</p><p>The first chapter examines the impact of new car dealer closures on …
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Reti complesse e analisi del segnale elettroencefalografico
… progression of brain disorders. Graph theory and network science tools have revealed fundamental mechanisms of functional brain organization in resting-state M/EEG analysis. Nevertheless, it is still not clearly understood how several methodological aspects may bias the topology of the …
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Differential Network Analysis based on Omic Data for Cancer Biomarker Discovery
… analysis could lead to biased results. Network-based methods provide a natural framework to study the interactions between biomolecules. Commonly used data-driven network models include relevance network, Bayesian network and Gaussian graphical models. In addition to data-driven network …
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Expression-based reverse engineering of plant transcriptional networks
… to reverse-engineer the cellular transcriptional networks using gene expression data as a compass. This kind of studies has been considerably assisted in the recent years by the development of high-throughput transcript measurement platforms, specifically gene microarrays and next-generation …
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Identifying and modeling perturbed networks in cancer through statistical and constraint-based analysis
… work has focused largely on modeling biological networks—using both statistical and mechanistic modeling approaches—with applications to medicine, energy, and genomic science. The more coarse-grained of these approaches use statistical analysis of high-throughput expression data to identify …
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SEA: a novel computational and GUI software pipeline for detecting activated biological sub-pathways
<p> <p>With the ever increasing amount of high-throughput molecular profile data, biologists need versatile tools to enable them to quickly and succinctly analyze their data. Furthermore, pathway databases have grown increasingly robust with the KEGG database at the forefront. Previous tools have …
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Protein-protein interactions and metabolic pathways reconstruction of Caenorhabditis elegans
Metabolic networks are the collections of all cellular activities taking place in a living cell and all the relationships among biological elements of the cell including genes, proteins, enzymes, metabolites, and reactions. They provide a better understanding of cellular mechanisms and phenotypic …
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Analýza a rekonstrukce komunikace typu Instant Messaging (YMSG a ICQ)
… použity v nástroji pro analýzu komunikace MS Network Monitoru.
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