Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 59 for “"nervous system development"”.
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GENETIC CONTROL OF EYE AND CENTRAL NERVOUS SYSTEM DEVELOPMENT
… the role of these Pax genes in neural development, by generating an allelic series of knock-in models at the Pax6 locus. We showed that Pax6(5a) and Pax2 could not replace Pax6 for its auto-regulation in lens induction or for neural differentiation in retina. In brain development, …
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Genetic Control Of Enteric Nervous System Development And Subtype Specification
… and sometimes, early death. In HSCR, the enteric nervous system (ENS) does not develop completely, resulting in a region of bowel lacking neurons. HSCR can be treated by surgically removing aganglionic bowel, but many children with HSCR have poor motility even after surgery, especially children …
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Serum Response Factor Regulates Multiple Aspects of Central Nervous System Development
… SRF participates in earlier aspects of central nervous system development such as neuronal projection establishment, cell-fate specifications, and neural stem cell homeostasis and survival. We report that SRF is critical for development of major axonal tracts in the forebrain. Conditional mutant …
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Ena/VASP proteins regulate vertebrate nervous system development : a thesis presented
Nervous system development is a complex morphogenetic process. Cell migration, axon guidance and many other regulated cell shape changes build a functional nervous system. These processes depend upon regulation of the actin cytoskeleton. Ena/VASP proteins are able to remodel the actin cytoskeleton …
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The role of cnd-1/NeuroD1 in C. elegans nervous system development
… transcription factor that is involved in nervous system development and pancreatic islet development. NeuroD1 -/- mice is uncoordinated, has seizures and a reduce brain size (Miyata et al. 1999). In C. elegans, the ortholog gene is <em>cnd-1</em>. Hallam et al. 2000, showed that …
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Retroviral envelope glycoproteins: mediators of neuropathology in nervous system development and neurodegeneration in HIV-1 infection
… act on advancing growth cones in the developing nervous system, leading to derangement of neuronal connectivity. We tested this hypothesis by applying an oligopeptide derived from the envelope glycoprotein of FeLV to the growth cones of cultured neurons and observing its effect on morphology and …
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The receptor tyrosine phosphatase Ptp69D and the receptor tyrosine kinase Pvr in Drosophila nervous system development
… are highly similar processes important for the development of the nervous system. Both processes involve the transduction of signals across the membrane, resulting in changes in the cytoskeleton. I have examined the roles of two receptors that are involved in axon guidance and cell migration in …
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Schmidtea mediterranea planaris as a novel animal model for investigating the dynamics of nervous system development in fetal alcohol spectrum disorder
… Alcohol Spectrum Disorder (FASD) is a prevalent developmental disease that is caused by excess in utero exposure to ethanol. The importance of timing and dosage of ethanol has been elucidated by previous investigations conducted with humans, rodents, and other model organisms, but challenges …
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Investigating the Impact of Metabolic Dysregulation on Nervous System Development and Function: A Study of CPT2 Deficiency in a Zebrafish Model System
… is an important energy source during early development and periods of starvation. Energy production is deficient when fatty acid β-oxidation is disrupted in humans, and a wide range of clinical presentations may develop. Carnitine Palmitoyltransferase (CPT) 2 is involved in the carnitine …
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Eph-Ephrin Signaling and the Role of EFN-4 in Caenorhabditis Elegans Nervous Systems Development
… ligands are required for multiple aspects of nervous system development including axon outgrowth, synaptic plasticity, and the formation of topographic maps in the visual system. The <em>Caenorhabditis elegans </em>ephrin-A, <em>efn-4</em>, has a defined role in hypodermal patterning but its …
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EXPRESSION OF SUBSTANCE P IN BRAINSTEMS OF VICTIMS OF SUDDEN UNEXPLAINED PERINATAL DEATH
… of the SP during the first phases of human nervous system development; to evaluate whether there are altered manifestations of this neuromodulator in victims of sudden death; to verify the correlation with maternal cigarette smoking and to see the evolutionary aspects of SP gene (TAC1) …
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Opioid Addiction Treatments During Pregnancy and Their Effects on Axonal Growth and Myelination in the Developing Central Nervous System
… is a need to understand potential effects on nervous system development. We previously showed effects of perinatal exposure to buprenorphine on axonal caliber and myelination in 26-day-old rat corpus callosum. These changes, detected at the end of rapid brain myelination and accompanied by …
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Leveraging gene/subnetwork meta-analysis to recover signal and deconvolute the interactions between genes in the risk of genetic disorders
… with top significant involved in signaling, nervous system development, and the immune system. Finally, the framework was applied to investigate the genetic overlap between suicidality and subcortical brain volume. This analysis identified potentially significant genes, hub genes with small …
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Repulsive axonal pathfinding requires the Ena/VASP family of actin regulatory proteins in vertebrates
Vertebrate nervous system development requires the careful interpretation of many attractive and repulsive guidance molecules. For the incredibly complicated wiring diagram comprising the vertebrate nervous system to elaborate properly, the highly motile "growth cone" at the tip of an axon must …
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Sox2 co-occupies distal enhancer elements with cell-type-specific POU factors to specify cell identity in embryonic stem cells and neural precursor cells
… associated with a subset of poised regulators of nervous system development, and upon differentiation into NPCs Sox2 selectively activates those which are important for progenitor cell state, while keeping others poised to become activated in later neural development. These data suggested that …
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Microfluidics for Low Input Epigenomic Analysis and Its Application to Brain Neuroscience
… cell identity during both disease and normal development. The inherent plasticity of the epigenome paves new avenues for developing diagnostic and therapeutic tools for human diseases. Microfluidic technology has improved the sensitivity and resolution of epigenomic analysis due to its …
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Mechanisms of Translational Control
… defining the role of selenoproteins in central nervous system development and maintenance.
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Unraveling the neurogenin/ngn-1 gene regulatory network of C. elegans using classical genetics and comparative transcriptomics
<p>Proper nervous system development is required for an organism’s survival and function. Defects in neurogenesis have been linked to neurodevelopmental disorders such as schizophrenia and autism spectrum disorders. Understanding the gene regulatory networks that orchestrate neural development, …
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Inhibition of Retinoic Acid Receptors Results in Defasciculation of the Trigeminal Nerve in Xenopus laevis
The anatomy of the cranial peripheral nervous system has been studied for over a century, yet surprisingly little is known about how the nerves are guided to their targets. The study of the development of these nerves has important implications for our understanding of craniofacial anomalies and …
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Genetic analysis of novel regulators of neuronal migration in Caenorhabditis elegans: the insulin/IGF-1 signaling pathway, a chromatin-binding factor ZFP-1 (AF10) and endogenous RNAi
… migration, a central component of proper nervous system development. When defective, it can lead to devastating conditions including epilepsy and mental retardation. In the nematode C. elegans, neurons undergo both short- and long-range migrations that are regulated by conserved pathways. …
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