Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"nerve repair"”.
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REPEATED BIPHASIC CONDUCTING CONDUITS FOR PERIPHERAL NERVE REPAIR
Each year 400,000 Americans sustain nerve transection injuries which require surgical intervention for repair. Due to rapid scar formation which blocks nerve outgrowth, there are no treatment options for the approximately 90% of patients who have gaps greater than 3 cm. Resultantly, researchers …
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Fabrication and evaluation of a collagen-based fiber-gel three-dimensional construct for peripheral nerve repair
Nerve regeneration following a peripheral nerve injury often relies on growth cone- mediated guidance and the presence of Schwann cells to support the regenerating axons and remyelinate portions of denervated nerve pathways. The emphasis of this work is to develop a synthetic nervous tissue …
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Evaluation of a simplified technique for nerve repair by means of entubulation by flexible controlled release glass
… microsurgical epineurial suturing as a means of repairing cleanly divided median nerves in a sheep model.
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Peripheral nerve regeneration through tubular devices : a comparison of assays of device effectiveness
Peripheral nerve injury affects nearly 200,000 patients annually in the United States and unless treated results in paralysis of skeletal muscle and loss of sensation. Previous studies in this laboratory have focused on comparing the effectiveness of various tubular devices in repairing …
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Molecular biology of peripheral nerve regeneration: Expression and role of Netrin-1, DCC and Runx2
Damage to the peripheral nerves causes a series of molecular, cellular, and structural changes critical to initiating a successful regenerative process involving degeneration, inflammation, axon re-growth and innervation of the denervated target, and finally functional recovery. In this thesis I …
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The role of ErbB inhibitors in promoting nerve regeneration in a mouse model of nerve injury
Nerve injury is a common clinical challenge that has a considerable impact on an individual’s quality of life and function. Despite multiple surgical strategies, functional outcomes following nerve injury remain poor. Increasing the rate at which axons regenerate could profoundly improve the …
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Peripheral nerve regeneration through collagen devices with different in vivo degradation characteristics
… people are treated each year for peripheral nerve injuries that require surgery. Functional recovery of motor and sensory capability is limited following autograft, the most common procedure for peripheral nerve repair. Tubulation repair of a transected peripheral nerve presents an …
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Investigating the Impact of Biochemical and Mechanical Stimuli on Motor Neuron Growth
Peripheral nerve injuries are one of the most prevelant trauma injuries, and the current golden standard for treatment is an autologous nerve graft. The use of tissue engineered nerve grafts has increased in recent years, a neural scaffold, cellular or acellular, is utilized to promote nerve …
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Deposition of Electroactive Polymers onto Polymer Nanofibers for Nerve Regeneration
Although peripheral nerves can regenerate after an injury through the Wallerian degeneration process, the degree of regeneration is often not efficient enough to achieve full return of functionality. To overcome the disadvantages of current nerve repair approaches, peripheral nerve tissue …
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The Role of Slit/Robo Signalling in Peripheral Nerve Regeneration
The role of Slit/Robo signalling in peripheral nerve regeneration. Slit/Robo chemorepulsive signalling has been shown to play a role in axon pathfinding during the development of the central nervous system. There is evidence that Slit/Robo are expressed in the adult intact and injured peripheral …
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Design and evaluation of neuroregenerative properties of 4D hydrogel scaffolds
… target due to its relevance in peripheral nerve repair, and to its connection to the non-regenerative central nervous system (CNS). Severe peripheral nerve injuries have a limited regenerative capacity, with interventions typically not leading to full functional recovery. Ways to improve …
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Median and Ulnar Nerve Injuries in Children and Adolescents- Long-term outcome and Cerebral reorganisation
A peripheral nerve injury may lead to serious disability and influence the individual´s quality of life. It is considered that children can regain better sensory and motor function after a peripheral nerve injury, but the exact mechanism behind such superior recovery is not known. The aim of the …
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The control of Schwann cell myelination during development and after nerve injury
… the number of macrophages present in the nerves of Sox2 overexpressing mice at both P60 and 21 days post injury. Phenotypically, Sox2 overexpressing mice 6 show signs of a peripheral neuropathy and animals have impaired motor and sensory function. These findings confirm that Sox2 is a …
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Novel signalling pathways resolving the inflammatory response during peripheral nerve regeneration
… homeostasis to resume within the peripheral nerves. This thesis aims to investigate the expression pattern and distinct function of VIP and PACAP and their receptors VPAC1, VPAC2 and PAC1 in the peripheral nerve post injury and how signalling through these receptors can act to promote …
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Crosslinked Hyaluronic Acid Hydrogel Networks Designed as Mechanical Actuators
… applications, such as wound closure/healing and nerve regeneration, where polymeric actuators have been underutilized. These applications however call for a polymer system that can actuate at controlled slow speeds and sustain this actuation for several days. At present there is a lack of such …
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MODIFYING CHONDROITIN SULFATION ENHANCES RETINAL GANGLION CELL AXON REGENERATION
… model of the glial scar and in vivo, using optic nerve crush (ONC) in adult mice. ARSB is clinically approved for replacement therapy in patients with mucopolysaccharidosis VI and therefore represents an attractive candidate for translation to the human CNS. My findings illustrate the importance …