Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"nerve agent"”.
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Enzyme and Directed Evolution Technologies For Nerve Agent Neutralisation
… insecticides and the possibility of using OPs nerve agents (NA) against civilian populations, the research and development of enzymes involved in the biotransformation and detoxification of OPs has attracted considerable attention in recent years. A number of enzymes have been identified that …
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Rapid scanning longwave infrared absorption spectroscopy of chemical nerve agent simulant destruction in fireballs
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-04-12 without embargo terms
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Uptake and Reaction Mechanisms of CO, H2O, and the Nerve Agent Simulant, DMMP with Single Atom-Modified Zirconium-based Metal-Organic Frameworks
… be more effective sorbents for compounds such as nerve agents than activated carbon owing to stronger interactions between the protective material and toxic compound of interest. One class of MOFs composed of zirconium-based nodes (Zr-MOFs) has been investigated extensively for their ability to …
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Interactions between anticholinesterases in an in vitro central nervous system preparation
… (e.g. paraoxon) and also as chemical warfare agents (nerve agents, e.g. sarin). These compounds rapidly inhibit the enzyme acetylcholinesterase (AChE), causing overstimulation within the cholinergic nervous system. If left untreated, this can be fatal. Current medical countermeasures to nerve …
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SYNTHESIS OF CHROMO FLUOROGENIC SENSORS FOR MOLECULAR RECOGNITION
… a series of molecule in order to recognize nerve agent simulant like DMMP (dimethylmethyphosphonate) by using firstly simple molecules as oximes that is well known are used in the detoxification therapy after nerve agents exposure. Unfortunately the change of the behaviour of these molecule …
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The Study of Zirconium Hydroxide and Zirconium (IV) Metal-Organic Frameworks as Reactive Substrates for the Decomposition of Chemical Warfare Agents
<p>Nerve agents have been described by the Center for Disease Control and Prevention to be the most toxic and rapidly acting of chemical warfare agents. The present study investigates the efficacy of zirconium hydroxide, Zr(OH)<sub>4</sub>, and Zr(IV) Metal-Organic Frameworks (MOFs) in the uptake …
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Investigation of Closed-Loop Control of Polyatomic Molecules
… methylphosphonate (DMMP), a simulant for nerve agent Sarin. The exploitation of the sensitivity of molecular fragmentation to laser pulse shapes represents a new way to discriminate molecular identity. Here we have shown manipulation of the branching M-(OCH3)+/M-(CH3)+, M-2(CH3)+/M-(CH3)+ …
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Electrochemical detection of chemical warfare agents
… Compound 2 reacted with alkylating agents like MeI, EtI, EtSCH₂CH₂Cl (MA) and (CN)(EtO)₂P(O) (NA) to form MeNH-Fc-COOMe (3), EtNH-Fc-COOMe (4), EtSCH₂CH₂NH-Fc-COOMe (5), (EtO)₂P(O)NH-Fc-COOMe (6), respectively. Cyclic voltammetry (CV) of these compounds showed different half-wave …
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Computational Investigations at the Gas-Surface Interface: Organic Surface Oxidation and Hydrolysis of Chemical Warfare Agents and Simulants
… the fundamentals of the hydrolysis mechanism for nerve agents by a catalyst of interest in the development of filtration materials for chemical-warfare-agent defense. By following the gas-surface reaction pathway of the nerve agent Sarin on the Lindqvist polyoxoniobate Cs8Nb6O19, we determined …
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Layer-by-layer carbon nanotube electrodes for flexible chemical sensor and energy storage applications
… sensors for real-time detection of a nerve agent simulant (dimethyl methylphosphonate (DMMP)). Available functional groups (-NH2 and -COOH) on the MWNT films offer a direct route for covalently attaching a receptor of interest to the MWNTs, in order to tailor the chemical specificity …
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Fundamental Investigations of Hazardous Gas Uptake and Binding in Metal-Organic Frameworks and Polyurethane Films
… triatomic ambient gases, and chemical warfare agents, with metal-organic frameworks (MOFs) and polyurethane coatings were conducted to build structure–property relationships for the nature and energetics of gas sorption within each material. Differences in the molecular structure of the guest …
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Polymer and covalent functionalization of single walled carbon nanotubes for electronic sensor applications
… organic compounds to include chemical warfare agents are developed. Active sensing materials were produced by crafting composites of synthetic polymers and single walled carbon nanotubes. Sensitivity to and selectivity for target analytes were augmented by the introduction of molecular …
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ANALYTICAL APPLICATIONS OF SURFACE-MODIFIED FUSED SILICA CAPILLARIES
… modifying a fiber optic capillary to detect nerve agents by immobilizing fluorescent labeled acetylcholinesterase (AChE) to the surface and using evanescent waves to monitor the enzyme activity. The hypotheses for the chemical sensor are that the improved enzyme activity of a recombinant …
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ANALYTICAL APPLICATIONS OF SURFACE-MODIFIED FUSED SILICA CAPILLARIES
… modifying a fiber optic capillary to detect nerve agents by immobilizing fluorescent labeled acetylcholinesterase (AChE) to the surface and using evanescent waves to monitor the enzyme activity. The hypotheses for the chemical sensor are that the improved enzyme activity of a recombinant …
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Fabrication of electrospun TiO2/polymer composite nanofibers for photocatalysis and degradation of toxins
… pharmaceutical pollution and chemical warfare agents (CWAs). To date the nerve agent, <em>O</em>-ethyl <em>S</em>-[2-(diisopropylamino)ethyl] methylphosphonothioate), also known as VX, is the world’s most lethal chemical substance. Some of these deadly nerve agents have been employed in various …
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Interfacial Energy Transfer in Small Hydrocarbon Collisions with Organic Surfaces and the Decomposition of Chemical Warfare Agent Simulants within Metal-Organic Frameworks
… the uptake and decomposition of chemical warfare agent (CWA) simulants on or within metal-organic frameworks (MOFs). The work presented here represents the first such study reported in with traditional surface-science based methods have been applied to the study of MOF chemistry. The mechanism and …
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Synthesis and kinetic processes in designed polymers
… undergoes accelerated rate of degradation and agent release. Fast relaxation imaging (FReI) is introduced as a novel technique to detect protein unfolding in situ by imaging changes in fluorescence resonance energy transfer (FRET) after temperature jump perturbations. Unlike bulk measurements, …
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The Chemistry of Metal Oxyhydroxides and their 3D Porous Hybrid Materials for the Capture, Transport and Degradation of Toxic Chemicals
… especially for toxic gases and chemical warfare agent simulants. We report and verify that the active sites in UiO-67 MOFs are the metal nodes (oxyhydroxides) and developed a paradigm which correlates the activities of the MOFs, the metal oxyhydroxides and their precursors. This new understanding …