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Showing 1 to 15 of 15 for “"nephrotic syndrome"”.
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The effect of indomethacin on glomerular permeability in the nephrotic syndrome
Contains fulltext : mmubn000001_246061790.pdf (Publisher’s version ) (Open Access)
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A study of omega-3 fatty acid therapy in patients with nephrotic syndrome
Patients with nephrotic range proteinuria have a higher risk of cardiovascular disease through qualitative and quantative changes in lipids and lipoproteins. The aim of this study was to examine the effect of omega-3 fatty acids derived from fish oil in this population. Treatment with omega-3 fatty …
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Nephrotic Syndrome and Glomerular Basement Membrane: Genetic Defect of the Laminin α5 Chain
Nephrotic syndrome is a heterogeneous group of disorders characterised by renal and extra-renal manifestations. Classic symptoms of nephrotic syndrome include severe proteinuria, hypoalbumiaemia, oedema and hyperlipidaemia. <br></br><br></br> Genetic studies of hereditary forms of nephrotic …
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Next-Generation Sequencing for New Gene Identification and for Diagnosis in Steroid-Resistant Nephrotic Syndrome
Nephrotic syndrome is clinically characterized by massive proteinuria, and hypoalbuminemia. It represents a heterogeneous group of glomerular disorders characterized by distinct causes and histopathologic lesions. The present thesis evaluates the contribution of genetics in conditions commonly …
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Clinico-pathological correlation and outcome in patients with mesangioproliferative glomerulonephritis in Cape Town: A single centre study
… subtype being reported as a common cause of nephrotic syndrome. This study will assess the outcome of patients with biopsy proven mesangioproliferative glomerulonephritis (MesPGN) from a single centre in Cape Town, South Africa. Methods The study is designed as 10-year retrospective analysis …
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Electron microscopic morphometry of podocyte foot process effacement as a tool to distinguish primary from secondary focal segmental glomerulosclerosis (FSGS)
… options. Primary FSGS commonly presents as nephrotic syndrome (NS), shows diffuse FPE with a FPW >1500nm, and is generally responsive to steroid therapy. Secondary FSGS does not present with NS (non-nephrotic), shows focal FPE and a FPW <1500nm, and does not respond to steroids. Sometimes, …
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Podocyte Melanocortin 1 Receptor Mediated Signaling
Treatment of patients with nephrotic syndrome (NS) is currently unspecific and directed at ameliorating the symptoms rather than eliminating the cause. NS is actually a multitude of glomerular diseases characterized by poorly understood disease mechanisms and symptoms that include proteinuria, …
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Regulation of Fluid-phase Uptake in Podocytes by Albumin-associated Lipids
… roles in maintaining the filtration barrier. In nephrotic syndrome, a major breakdown of the kidney filtration barrier associated with proteinuria, hyperlipidemia, and edema, podocytes undergo changes in morphology and appear to internalize serum proteins. We postulated that fluid-phase uptake by …
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The Dietary and Endogenous Components of Human Serum Triglycerides in Alimentary Lipemia
… (6), alcoholism (7, 8), pancreatitis (9), nephrotic syndrome (3), and hypothyroidism (3). An important variable in hyperlipemia is that it may be due largely to excessive amounts of exogenous triglyceride, of endogenous triglyceride , or a combination of both. | Following the metabolic …
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Role of T cells and cytokines in the induction of tolerance to renal tubular antigen in active Heymann nephritis
… Membranous nephropathy (MN) is a common cause of nephrotic syndrome in humans, and many patients progress to end-stage kidney disease. The best available animal model of MN is active Heymann nephritis (HN) in which rats are immunized with renal tubular antigen (RTA) in complete Freund's adjuvant …
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Epidemiology and clinical outcomes of patients with idiopathic membranous glomerulonephritis at Groote Schuur Hospital over a ten year period
… nephropathy (IMGN) is an identified cause of nephrotic syndrome in South Africa. Early attainment of complete remission (CR) or partial remission (PR) in patients with IMGN has been shown to slow progression to ESRD. There is a dearth of outcome studies in Africa on IMGN. METHODS: This study …
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Molekulare Grundlage des Kongenitalen Nephrotischen Syndroms : Podocin rekrutiert Nephrin in Lipid Rafts
Das Kongenitale Nephrotische Syndrom ist ein heterogenes Krankheitsbild, das durch schwere Proteinurie und Niereninsuffizienz gekennzeichnet ist. Mutationen der Gene NPHS1 und NPHS2, die die Proteine Nephrin und Podocin kodieren, führen zu frühzeitig einsetzender Proteinurie, raschem Fortschreiten …
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Neph-Proteine interagieren mit dem Multiadapterprotein ZO-1
Die Studie hereditärer Erkrankungen des glomerulären Filters der Niere hat zu einem dramatischen Wissenszuwachs und einem komplett neuen Verständnis der Funktion des Nierenfilters und der Entstehung des nephrotischen Syndroms geführt. Neph-Proteine wurden als Proteine der Schlitzmembran des …
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Mutationsanalyse der verantwortlichen Gene NPHS2 und Wilms-Tumor-Suppressorgen beim Nephrotischen Syndrom
Das Nephrotische Syndrom (NS) ist gekennzeichnet durch das Auftreten von Proteinurie, Hypoalbuminämie und Hyperlipidämie. Je nach Ansprechen auf die Steroidtherapie wird das NS in steroid-sensibel (SS) und steroid-resistent (SR) eingeteilt. Das autosomal-rezessive, steroid-resistente NS (SRNS) ist …