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Showing 1 to 20 of 43 for “"nephron"”.
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Mechanisms underlying progressive nephron injury in chronic kidney disease
Includes bibliographical references.
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Characterizing Renal Interstitial Heterogeneity and Its Role in Nephron Patterning
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Single nephron structure and function, and renal effects of catecholamines in the dogfish, Scyliorhinus canicula
1. The organisation of the kidney, and nephron structure of Scyliorhinus canicula, was examined using light and scanning electron microscopy. 2. Visceral epithelium of the glomerulus was composed of podocytes, primary processes and interdigitating pedicels. Morphological variations were common, …
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Regulation of Functional Expression of Mechanosensitive Trpv4 Channel In The Distal Nephron By Dietary Potassium and Sodium Intake
… channel is predominantly expressed in the distal nephron (DN) and its activity is essential for [Ca<sup>2+</sup>]<sub>i</sub> elevations in response to increased tubular flow. Here, I probed the physiological mechanisms controlling TRPV4 function and expression in the DN. I found that renal TRPV4 …
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The Novel Role of Dnmbp In Kidney Development
… of up to a million epithelial tubules called nephrons. Disruption of nephron development is one of the many congenital anomalies that cause CAKUT, often resulting in chronic or end-stage renal disease which requires transplant. During nephron epithelialization, the formation of stable …
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Balancing Renewal and Differentiation of Progenitor Cells in the Developing Kidney
… through individual functional units called nephrons. While nephron number may decrease during one's lifetime (due to various kidney injuries or hypoxic events), new nephrons do not form in adults. This is most likely due to the absence of nephron precursor cells. If nephron number falls …
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The Role of Daam1 In Kidney Development
… of epithelial tubules. Kidney tubules are called nephrons, and their morphology is important for kidney function. Nephrons develop from mesodermally derived aggregates of progenitor cells. The nephric progenitors organize into nephric tubules lined with hair-like sensory projections called cilia. …
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The Role of Daam1 In Kidney Development
… of epithelial tubules. Kidney tubules are called nephrons, and their morphology is important for kidney function. Nephrons develop from mesodermally derived aggregates of progenitor cells. The nephric progenitors organize into nephric tubules lined with hair-like sensory projections called cilia. …
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Fetal programming of renal morphology and function
… functions, also appear to impact upon nephron number. In this study, the feeding of a 9% casein diet to pregnant rats, a mild protein restriction, reduced nephron number in the offspring, which progressively declined with age compared to those exposed to an 1 8% control diet. At weaning …
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Impact of Differentiation Status of Kidney Progenitors In Wilms Tumor Development
… a progenitor-specific manner. We found that the nephron progenitors but not the stroma progenitors were able to give rise to Wilms tumors and that the different types of mutations introduced into nephron progenitor cells resulted in Wilms tumors with differing histology and expression of …
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Ionenkanäle während der Nephrogenese
… mittels Immunhistochemie in Sammelrohr- und Nephron-Epithelien untersucht. Der Effekt von cAMP auf die ROMK-mRNA-Expression wurde gemessen und der Einfluss von Kalium-Kanalmodulatoren auf das Wachstum von Nephron-Kulturen in vitro und von HEK293 Nierenepithel-Zellen bestimmt. Ferner wurde die …
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Acidification of Luminal Fluid by the Rabbit Cortical Collecting Tubule Studied in Vitro
… as it exitted from the distal end of perfused nephron segments.
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Modeling Renal Anomalies Associated with Li-Fraumeni Patients: A Novel Role for p53 in Kidney Development
… profoundly disrupts the development of multiple nephron segments in <em>Xenopus</em> embryos. Future studies will further explore the role of p53 in nephron development by modeling the effects of Li-Fraumeni patient-derived mutations in the developing kidney.</p>
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Investigating the control of epithelial polarisation in human kidney organoids
… development, intermediate mesoderm-derived nephron progenitor cells of unpolarised mesenchymal character undergo a mesenchymal-to-epithelial transition (MET) to yield the renal vesicle (RV), the first epithelial structure from which the main tubular component of the kidney arises. Despite …
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Wilms' tumour outcomes at Red Cross Children's Hospital 1979-2003
… evolved from simple nephrectomy into the use of nephron-sparing techniques. METHODS: A retrospective analysis was performed on all patients diagnosed with Wilms' tumour between January 1979 and December 2003. Treatment was according to National Wilms' Tumor Study Group protocols. For unilateral …
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EXISTÊNCIA DA ALÇA DE HENLE EM CHELONOIDES DENTICULATUS E EFEITOS DA FUROSEMIDA EM CHELONOIDES DENTICULATUS (Linnaeus, 1766) E CHELONOIDES CARBONARIUS (Spix, 1824)
The objective of this work was to analyze the nephron of the jabuti Chelonoides denticulatus and to verify the existence of the Henle loop in the kidney of this species, besides, to test the action of the diuretic furosemide in the jabutis Chelonoides denticulatus and Chelonoides carbonarius, since …
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The Effects of Accessory Proteins on ENaC Function
… sodium reabsorption in the distal tubules of the nephron in the kidneys. It is here the final, yet critical, 3% to 5% of sodium reabsorption that dictates blood pressure occurs. In this study, β-ENaC was cloned into pESC-Leu and pESC-Leu/γ in order to further characterize accessory proteins in …
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Uncovering the Critical Amino Acids in the Beta Bubunit of the Epithelial Sodium Channel (ENaC)
… partially regulated in the distal tubules of the nephron in the kidney via a membrane channel called the epithelial sodium channel (ENaC). The structure, regulation and assembly of ENaC’s subunits is not yet fully understood. In this study, error prone polymerase chain reaction (EP-PCR) was used …
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Kidney tubulogenesis in human renal organoids: an investigation into the contribution of the microtubule-associated protein DCDC2
… initial tube which subsequently extends into the nephrons, which are the functional unit of the kidney. When kidney nephrons are lost due to disease or damage, kidney function is reduced because the total number of nephrons in an individual is formed pre-natally and nephrons cannot be added after …
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Age-related changes in renal function, membrane metabolism, transporter activity and abundance in hypokalemic Fischer 344 x Brown-Norway F1 rats
… and three microdissected segments of the nephron (proximal convoluted tubule [PCT], cortical collecting tubule [CCT], and medullary collecting tubule [MCT]). In both age groups, potassium depletion decreased total body potassium content; plasma ldosterone fell while plasma cholesterol and …
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