Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"nephrogenesis"”.
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Impact of Differentiation Status of Kidney Progenitors In Wilms Tumor Development
… ablation in stroma progenitors did not affect nephrogenesis but that <em>Wt1</em> is required for nephron progenitors to undergo mesenchyme to epithelia transition.</p>
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Advanced in vivo imaging of the interactions between vascular and renal development in the zebrafish pronephric kidney
… between renal and cardiovascular systems during nephrogenesis at the level of the blood filter. METHODOLOGY Owing to the optical transparency and rapid external development of the embryo, the zebrafish provides a research model for advanced imaging technologies, allowing us to visualise …
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Tissue-resident immunity in the human kidney
… of the developmental trajectories of early nephrogenesis. Within the immune compartment, we charted the landscape of immune cells, and the seeding of these cells through early development, identifying a macrophage subset in mature kidneys with transcriptional similarity to macrophages seeded …
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Identification of Familial Wilms Tumor Predisposition Genes Using Whole Genome Sequencing
… into the role of sphingolipid signaling in nephrogenesis and cancer development. Significantly, the communication of these results directly to patients within each family allows for the continued monitoring of new family members for the potential early detection of not only Wilms tumor, but …
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Investigating the control of epithelial polarisation in human kidney organoids
… Understanding how to more precisely direct nephrogenesis in vitro may help to overcome the reproducibility bottleneck experienced by all organoid fields, and possibly guide novel regenerative therapies in the future.
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AEROBIC FITNESS AND THE RENIN ANGIOTENSIN SYSTEM IN ADOLESCENTS BORN PRETERM WITH VERY LOW BIRTH WEIGHT
… in terms of blood pressure (BP) regulation. Nephrogenesis begins by 9 weeks gestation, however kidney formation is not complete until around 32-36 weeks.8 Both animal and human studies indicate that PT birth is associated with reduced nephron number, which may lead to hypertension.8,9 There …
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Exploring the impact of maternal obesity on offspring renal morphology and later life health
… bud branching, an important precursor of nephrogenesis, were increased in fetuses exposed to maternal obesity with exercise as opposed to obesity alone. Additionally one of these gene markers correlated negatively with maternal insulin levels. Protein markers indicative of an active …
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A Novel Role For Dyrk1A In Kidney Development
<p>Congenital anomalies of the kidney and urinary tract (CAKUT) are a leading cause of pediatric kidney failure and encompass a wide range of structural malformations resulting from defects in morphogenesis. CAKUT occur in ∼1/500 live births and with an average wait time of 3-5 years for a kidney …
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The Novel Role of Dnmbp In Kidney Development
<p>Congenital anomalies of the kidney and urinary tract (CAKUT) accounts for nearly one-fourth of all birth defects and more than 40% of pediatric end-stage renal disease, yet only 10-20% of CAKUT cases have a known monogenetic cause. Human kidneys are composed of up to a million epithelial tubules …
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Die Wnt-Signalkette in der Pathophysiologie der kongenitalen obstruktiven Uropathie der Ratte
Ziel: Um die Rolle der Wnt-Signalkette in Hinblick auf die Pathophysiologie der kongenitalen obstruktiven Uropathie der Ratte zu ergründen, wurden in der vorliegenden Arbeit die Expressionsmuster ausgewählter Gene untersucht. Methoden: Es wurde die totale zelluläre mRNA aus Nieren von Ratten …