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Showing 1 to 20 of 60 for “"nephritis"”.
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Pregnancy and Lupus Nephritis: A Review
The file named "BANSAL-DISSERTATION-2017.pdf" is the primary dissertation file. A supplemental PDF file ("Appendix - Data.pdf") is also available and may be viewed individually.
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Acute tubulo-interstitial nephritis : clinical profile and pathogenic mechanisms
Acute tubulointerstitial nephritis (ATIN) is an important cause of renal morbidity. This study showed that it represents up to 8% of acute renal failure where biopsy material was available and accounted for 1% of all renal biopsy material. This study, which is believed to be the largest single …
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M2 Polarization and Pro-Fibrotic Transition of Lupus Nephritis Macrophages
… feature of autoimmune diseases, such as lupus nephritis (LN), in which persistent immune activation leads to progressive kidney injury and fibrosis. Macrophages play a central role in this process because of their functional plasticity and ability to respond to environmental cues. Classically …
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Isoform-Selective HDAC Inhibition for the Treatment of Lupus Nephritis
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease requiring a genetic predisposition coupled with an environmental trigger in order for initiation of disease. While the exact pathoaetiology has yet to be determined, both B and T cell dysregulation are thought to contribute to …
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Serologic, Pathologic and Immunologic Features of Experimental Leptospiral Nephritis in Dogs
Made available in DSpace on 2014-12-09T22:30:18Z (GMT). No. of bitstreams: 1 6901466.pdf: 6392551 bytes, checksum: 806871d9efabc617b79e0be6ed1a2b7e (MD5) Previous issue date: 1968
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Tubulointerstitial nephritis and uveitis syndrome : case report and review of the literature
… To review the literature on tubulointerstitial nephritis and uveitis (TINU) syndrome, and to report a case of a patient with relapsing polychondritis (RP) and TINU syndrome. Method: TINU syndrome is a rare oculorenal inflammatory disorder. It is more common in young women with autoimmune …
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Outcomes of renal transplantation in patients with lupus nephritis: a single centre study in Cape Town
Background: Kidney disease (lupus nephritis [LN]) constitutes a feature of systemic lupus erythematosus (SLE) in up to 50 - 70% of patients with the disease. Although most LN patients are suitable for renal transplantation when they develop end stage renal disease (ESRD), the risk of recurrence of …
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Retrospective comparison of cyclophosphamide and mycophenolate mofetil in lupus nephritis at Groote Schuur Hospital nephrology unit
Background. Lupus nephritis (LN) can be complicated with requirement for kidney replacement therapy and death. Efficacy of induction therapies using mycophenolate mofetil (MMF) or intravenous cyclophosphamide (IVCYC) has been reported from studies, but there is limited data in Africans comparing …
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Clinico-pathological features of repeat renal biopsies in patients with lupus nephritis at Groote Schuur Hospital, Cape Town
… Repeat renal biopsies in patients with lupus nephritis (LN) are usually done to guide treatment or to establish disease chronicity. Their value is not clear from available literature. There is also no available data in Africa to guide clinicians. Methods: This was a retrospective study of …
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A retrospective review of Granulomatous Interstitial Nephritis (GIN) amongst HIV-infected patients at Groote Schuur Hospital, Cape Town
… In the literature granulomatous interstitial nephritis (GIN) is most commonly attributed to sarcoid and drug reactions and occurs in 0.5- 1.37% of kidney biopsies. Current data is only from developed countries and rarely in HIV positive individuals. As our yield of GIN appeared high we …
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Role of T cells and cytokines in the induction of tolerance to renal tubular antigen in active Heymann nephritis
… available animal model of MN is active Heymann nephritis (HN) in which rats are immunized with renal tubular antigen (RTA) in complete Freund's adjuvant (CFA). Rats develop heavy proteinuria, a key measure of glomerular damage, and the disease is histologically identical to human MN. It has been …
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The value of urotropine, hexamethylenetetramine and metramine in the prophylaxis of scarlatinal nephritis: derived from 300 cases of scarlatina
… Observations more especially in relation to Nephritis in 300 cases of Scarlatina, which were treated at the Edinburgh City Hospital from the 9th. August 1905 to the 5th. January 1906.
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Using urinary MCP-1 and TWEAK to assess disease activity in a cohort of South African patients with lupus nephritis
… chronic kidney disease (CKD). Diagnosis of lupus nephritis (LN) is dependent on renal biopsy. Due to its invasiveness, repeat renal biopsy for monitoring disease activity is not recommended, thus creating a need for noninvasive and accurate biomarkers. Monocyte chemoattractant protein-1 (MCP-1) …
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Correlation of urinary mcp-1 and tweak with renal histology and early response to therapy in newly biopsied patients with lupus nephritis in cape town, South Africa
… immunosuppression in patients with active lupus nephritis (LN), however this is guided by renal biopsy which is invasive and not freely available in most centres. Novel urinary biomarkers such as monocyte chemoattractant protein-1 (MCP-1) and tumour necrosis factor-like weak inducer of apoptosis …
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Investigation of the role of copy number variation in the susceptibility to systemic lupus erythematosus
… patients (divided into those with and without nephritis) compared to healthy control subjects. Using this method, we identified three genes, CFHR 1/3, WNK1 and RASGRP3, where loss of CN was more frequently found in SLE patients without nephritis. Thus the results presented in this thesis …
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Investigation of the role of copy number variation in the susceptibility to systemic lupus erythematosus
… patients (divided into those with and without nephritis) compared to healthy control subjects. Using this method, we identified three genes, CFHR 1/3, WNK1 and RASGRP3, where loss of CN was more frequently found in SLE patients without nephritis. Thus the results presented in this thesis …
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The Dendritic Cell Response to Exogenous and Endogenous Danger Signals
… of end organ damage in the form of lupus nephritis. Viral infections have long been associated with the development of systemic autoimmune disease, but the mechanisms by which chronic bacterial infections may promote autoimmunity remain unclear. In chapter three we show that a component of …
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Mechanistic Insights on The Immunomodulatory Functions of Diverse Environmental Factors on Systemic Autoimmunity
… the lupus-associated kidney inflammation (lupus nephritis) when given at the initiation vs. continuation phase of lupus. Unlike tRA treatment during active disease, pre-pristane treatment with tRA aggravated glomerulonephritis through potentiating leukocyte activation and trafficking to the …
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Exom-Sequenzierung bei unklarer chronischer Niereninsuffizienz anhand definierter renaler Biopsiemerkmale
… (CKD) durch chronisch tubulo-interstitielle Nephritis (CIN) unbekannter Ursache bei Erwachsenen. Die Auswahl der Studienkohorte erfolgte anhand festgelegter histologischer und klinischer Kriterien (prädominante CIN unklarer Ursache), die sich in 52 von 785 Biopsie-Befunden aus den Jahren 1983 …
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