Global ETD Search
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Showing 1 to 8 of 8 for “"nephrin"”.
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Nephrin und CD2AP aktivieren den PI3-Kinase/AKT-Signalweg im Podozyten
… daß die glomerulären Schlitzmembranproteine Nephrin und CD2AP mit p85, der regulatorischen Untereinheit der PI3-Kinase, interagieren. <br>Die Interaktion von Nephrin und p85 ist Phospho-Tyrosin-abhängig und kann durch Genistein, das die Phosphorylierung des intrazellulären Nephrin-Abschnittes …
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Molekulare Grundlage des Kongenitalen Nephrotischen Syndroms : Podocin rekrutiert Nephrin in Lipid Rafts
… der Gene NPHS1 und NPHS2, die die Proteine Nephrin und Podocin kodieren, führen zu frühzeitig einsetzender Proteinurie, raschem Fortschreiten der Erkrankung und letzlich zur terminalen Niereninsuffizienz. Diese Tatsachen lassen vermuten, dass beide Proteine für die Integrität des …
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Characterization of signaling pathways regulating nephrin endocytosis in kidney podocytes: novel roles for Nck and ShcA adaptor proteins
… and acts as a discerning filtration pore. Nephrin is a key component of this barrier and disrupted nephrin trafficking is suggested to be a source of filtration breakdown, although evidence of this within the complexity of the body remains incomplete. Further, although nephrin’s tyrosine …
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Significance of α-Lipoic acid on cell viability and nephrin in human podocytes under normal and high glucose conditions
… characterized by loss or dysfunction of hPC. Nephrin is an important protein in hPCs and was found to maintain integrity and function of the slit diaphragm. Additionally, nephrin phosphorylation mitigates stress in hPC. α-Lipoic acid (α-LA) is a naturally occurring compound, also licensed for …
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Regulation of WASP in Actin Signaling: From Angstroms to Microns
… signaling network consisting of WASP, Nck and Nephrin is necessary to maintain the structural and functional integrity of glomeruli in the kidney. Upon phosphorylation, three phosphotyrosine motifs in the cytoplasmic domain of a transmembrane scaffolding protein Nephrin recruit the C terminal …
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Spatiotemporal Control of Actin Cytoskeletal Machinery in Cells: Multivalency Mediated Protein Clustering at the Plasma Membrane and Optogenetic Tool Development
… multivalent interactions among proteins in the Nephrin/Nck/N-WASP actin-regulatory pathway can drive clustering of the components at the plasma membrane in cells. Generation of the micronsized domains is dependent on the phosphorylation-mediated interaction between the transmembrane protein, …
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Phase Transitions of Multivalent Adaptor Proteins
… which is the filtration barrier of our kidneys. Nephrin, an integral membrane protein at the slit-diaphragm, interacts with its partners Nck and N-WASP in a multivalent fashion. I show here that these interactions create large assemblies that phase separate into liquid droplets, both in solution …
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CELLULAR AND MOLECULAR MECHANISMS OF AT2R MEDIATED ANTI-PROTEINURIC ACTIVITY
… of glomerular slit diaphragm proteins (nephrin and podocin) the estimated glomerular filtration rate remained unaffected which together suggest that HSD intake caused tubular proteinuria. The in vivo findings in megalin recycling impairment were confirmed by the in vitro studies …