Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"neovascularisation"”.
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Stimulating angiogenesis into biomaterials through the delivery of growth factors
… angiogenesis, this PhD thesis hypothesized, that neovascularisation of porous polyurethane (PU) can be increased by delivery of vascular endothelial growth factor (VEGF1ss) and platelet derived growth factor (PDGF-BB). To prove this hypothesis, subcutaneous implantation of PU discs was established …
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Investigation of the role of Glil+ cells in retinal angiogenesis and fibrosis.
… and blindness. The process of pathological neovascularisation into the formation of a fibrovascular membrane is not completely understood. Recent research has implicated the Hedgehog pathway transcription factor, Gli1, in the development of fibrosis in numerous organs. This study aims to …
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Investigating the role of the complement system in the pathogenesis of sub-retinal fibrosis in neovascular age related macular degeneration
… AMD (nAMD). nAMD is characterised by choroidal neovascularisation (CNV), which is the growth of newly formed blood vessels into the retina. A neovascular lesion is formed, and the end stage of nAMD is macular fibrosis in which the neovascular lesion transitions into a fibrovascular lesion. This …
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Mechanical and biological augmentation of allograft and synthetic graft in impaction bone grafting
… II: Evidence of biocompatibility, neovascularisation and new bone formation in<br/>impacted allograft and PDLLA scaffolds seeded with HBMSC, in vivo was assessed<br/>and compared to allograft and PDLLA alone.<br/><br/>Part III: The laboratory work was translated into the clinical …
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To investigate whether VEGF and KDR polymorphisms are associated with chronic Achilles tendinopathy and self-reported measurements of tendon pain
… theories implicate structural changes and neovascularisation in tendinopathy. Vascular endothelial growth factor (VEGF) and its receptor referred to as kinase domain receptor (KDR) are key regulators of neovascularisation and can be associated with pain. Common DNA sequence variants within …
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Multifokale Elektroretinographie bei retinalen Gefäßverschlüssen
… technique can give prognostic information about neovascularisation risks. The intraindividual comparison of affected and fellow eye promises to be more sensitive than comparison with a normal collective.
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Cell penetrating peptide for ocular drug delivery
… population of the developed world. Choroidal neovascularisation (CNV), the hallmark of neovascular AMD, results in the loss of sharp central vision due to breakdown of the blood retinal barrier (BRB), unregulated blood vessel proliferation and vascular leak, particularly into the macula of the …
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Dense Collagen Materials and the Modulation of Fibrillogenesis for Tissue Engineering
… exhibiting host-cell infiltration and early neovascularisation without adverse fibrosis. Overall, this scalable absorptive-deformation method produces robust collagen tubes and adaptable sheets in a single platform to better mimic real tissue, opening the way to superior vascular grafts, …
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Stimulation of angiogenesis through growth factor delivery from synthetic heparinised hydrogels
… endothelial cells and human dermal fibroblasts. Neovascularisation was quantified in a subcutaneous rat angiogenesis model in which hydrogel growth factor combinations were implanted within porous polyurethane discs and analysed after a 4 week period. A novel hybrid hydrogel able to degrade …
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Exploring vasculogenic mimicry and anti-angiogenic therapy resistance within breast cancer patient-derived tissue xenograft models
Therapeutically targeting tumour neovascularisation with anti-angiogenic therapy (AAT) holds much promise to halt tumour growth and inhibit metastasis, however AAT trials have not delivered the predicted clinical success in a large amount of the cancer types tested, including breast cancer. It has …
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The role of image processing and artificial intelligence machine learning-based systems for unbiased evaluation of human coronary atherosclerotic plaque progression and vulnerability, and in response to pharmacotherapy
… and presence of macrophages, calcific nodules, neovascularisation, and cholesterol crystals are associated with major adverse coronary events (MACE). Many of these features change with drug or device therapy, including drugs that reduce patient events with minimal changes in plaque volume. …
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Development and assessment of supercharged platelets as a novel drug delivery mechanism for promoting cardiac regeneration
… by promoting cardiomyocyte proliferation and neovascularisation processes. A lentiviral approach was employed for the genetic engineering of megakaryocytes, the precursor cells of platelets. Lentiviral plasmids, designed for the targeted delivery of proteins to the megakaryocyte and platelet …
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Investigation of the synovial tissue-homing mechanisms of circulating mononuclear phagocytes in treatment-naïve psoriatic arthritis.
… (MPs) are abnormal in PsA, involved in neovascularisation, and the production/development of key cytokines and adaptive effectors. I aimed to identify the key interactions that drive MPs migration to joint tissue in active treatment-naïve PsA. I profiled each circulating MPs subset from …
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Lrg1 in preeclampsia and heart failure: role as a biomarker and mediator of disease
… its functions have been studied in aberrant neovascularisation in the eye as well as being a key player in epithelial-mesenchymal transition (EMT). Its involvement in angiogenesis and inflammation have recently been established, making it a potential candidate as a therapeutic target for many …
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Rational enzyme-directed prodrug development : exploiting tumour hypoxia to target the bioactivation of cytotoxic prodrugs
… in systemic oxygen supply, vascular tone, neovascularisation, iron homeostasis, glucose metabolism, drug detoxification and protein chaperoning. The details of the cis-acting sequences and transcription factors that mediate this oxygen-sensitive gene control are beginning to emerge. This …
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Role of pericytes in the barrier task
… to microvascular degeneration and pathological neovascularisation, is critical in order for the development of novel therapies to complement, or improve upon, current treatment options. This research evaluates the potential of human adipose stem cells (hASCs) in differentiating into the …
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Minimally invasive treatment of venous insufficiency using endovenous laser ablation
… to an incompetent below-knee GSV and ten to neovascularisation. Of five recurrences after EVLA, two were related to neoreflux in the groin tributaries and one to recanalisation. Clinical recurrence was associated with worse QoL (AVVQ scores) (P < 0.001). Study 3: 232 patients were included. …
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Development and characterisation of a heparinised fibrin hydrogel as a delivery vehicle for regenerative medicine
… of VEGF has previously been seen to stimulate neovascularisation into heparinised PEG hydrogels in our laboratory and it was hypothesised that the high levels of vascularisation stimulated by fibrin alone may have obscured the VEGF induced angiogenesis. Further studies exploring VEGF dosage and …
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Characterisation of endothelial cell metabolic plasticity and vascular remodelling in the retina
Diabetic retinopathy (DR) is the most frequently occurring microvascular complication of diabetes mellitus, where the later stages of the disease are often is chaemia driven which can result in severe vision loss. A key component cell of the retinal neurovascular unit is the vascular endothelium, …