Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"neopterin"”.
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Einfluß von Pteridinen auf redoxsensitive biochemische Vorgänge
Die Pteridine Neopterin und 7,8-Dihydroneopterin sind Produkte aktivierter humaner Makrophagen. Ihre biochemische bzw. immunologische Funktion ist noch nicht endgültig geklärt. Doch weisen viele bisherige Ergebnisse auf eine mögliche Rolle als Modulatoren von Redoxgleichgewichten in biologischen …
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Aspects of Tuberculosis and HIV Coinfection in Patients at Ethiopian Health Centers
… immune system, both on peripheral CD4 cells and neopterin as a marker of immune activation. In paper III, we found that 25% of HIV negative patients with TB had low CD4 cell count (below 500 cells/mm3). These levels increased until end of TB treatment but not to levels found in healthy controls, …
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Metal binding to transferrin and immune reactions in Parkinson's disease
… Tf receptor system. A significant elevation in neopterin was demonstrated within the plasma of untreated PD patients compared to controls suggesting the activation of a cellular immune response. Furthermore, plasma neopterin was lower in treated compared to untreated PD patients, although the …
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Tetrahydrobiopterin Metabolism in Mental Retardation
… urine showed elevated biopterin level and normal neopterin-biopterin ratio. Dihydropteridine reductase (DHPR) deficient subjects showed low urine THB level with low blood DHPR activity. Acute oral phenylalanine loading in man produces a transient rise in total biopterin and in the rat a decrease …
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Identification and Characterization of the Enzymes Involved in Biosynthesis of FAD and Tetrahydromethanopterin in Methanocaldococcus jannaschii
… tetrahydromethanopterin and FAD. 7,8-Dihydro-D-neopterin 2',3'-cyclic phosphate (H₂N-cP) is the first intermediate in the biosynthesis of the pterin portion of tetrahydromethanopterin (H₄MPT), a C₁ carrier coenzyme. This intermediate is produced from GTP by MptA (MJ0775 gene product), a new …
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Kynurenines in neurological disorders
… for all patients, by measuring the levels of neopterin and the lipid peroxidation products, malondialdehyde and 4-hydroxynonenal. Patients with late stage HD showed abnormal tryptophan metabolism via the kynurenine pathway, together with increased inflammation and oxidative stress. Increased …
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Biopterin metabolism in health and disease
… assay. Secondly the urine concentration of neopterin and biopterin was estimated by high performance liquid chromatography. Thirdly the urine concentration of tetrahydrobiopterin was determined by an enzymatic assay using phenylalanine hydroxylase. The results obtained have been correlated …
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HIV-associated neurocognitive disorders biomarkers and the response to antiretroviral therapy
… Disorders (HAND) biomarkers (serum neopterin, osteopontin and neurofilament H) to determine their relationship to the severity of cognitive impairment at baseline in HAART-naïve patients, and whether initial levels of these biomarkers related to the change in cognitive function a …
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Investigation into the biochemical changes in Tourette Syndrome with a potential for pharmacological manipulation
… predominantly interferon-y (INF-y). Plasma neopterin, which shows parallel increase with KYN following immune stimulation, was also found elevated in one of these studies positively correlating with KYN. In the present work animal studies suggested that KYN potentiates and quinolinic acid …
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Metabolomics of cerebrospinal fluids to identity novel biomarkers as a predictive tool for brain inflammatory conditions
… pathway, nitric oxide pathway and elevation of neopterin. The use of the adjacent ratios such as kynurenine/tryptophan, anthranilic acid/3-hydroxyanthranilic acid and ADMA/arginine in combination with neopterin can serve as a potential cerebrospinal fluid biomarker panel to predict …
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The biogenesis of erythropoietin during inflammation
… interleukin-6, tumour necrosis factor-α, and neopterin were assayed for inhibition of erythropoietin synthesis by HepG2 cells in culture. All, except neopterin, effected dose-dependent reductions in the secretion of the hormone. Interleukin-1β and tumour necrosis factor-α down-regulated …
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Biochemical aspects of Tourette's Syndrome
… Syndrome (TS) patients with normal TRP and neopterin. The aim of our initial pilot study was to confirm this increase in KYN in fasting human TS patients compared with normal controls, and to see how changes in diet :ay influence certain kynurenine pathway variables. However, we failed to …
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Bacterial Cyanide Assimilation: Pterin Cofactor and Enzymatic Requirements for Substrate Oxidation
… included, for example, biopterin, monapterin and neopterin, all of which were also identified in cell extracts. A related CNO-mediated mechanism of cyanide utilization was identified in cyanide-degrading P. putida BCN3. This conclusion was based on (i) the recovery of CO2 and NH3 as enzymatic …
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Bedeutung der mikrobiellen Transmission im SIV-Rhesusaffen-Tiermodell für die HIV/AIDS-Pathogenese
… auf. Dagegen konnte man anhand der Immunmarker Neopterin, einem Produkt aktivierter Makrophagen, und der HLA-DR Expression, die bei Aktivierung von T-Zellen zunimmt, deutlich zwischen der Gruppe mit dem schnellen und der mit dem langsamen Krankheitsverlauf unterscheiden. Hierbei fiel auf, dass …
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ROLE OF PINCH IN ABERRANT TAU PHOSPHORYLATION IN HIV CNS DISEASE
… T-cell count, plasma and CSF viral burden, CSF Neopterin, white blood cell (WBC) count, and antiretroviral CNS penetration-effectiveness (CPE). Results suggest that in these HIV participants, changes in CSF levels of PINCH appear to correlate with changes in plasma CD4+ count and with changes in …