Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"neoplastic lesions"”.
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Grape Seed Extract as an Adjunct for Modulating Colon Carcinogenesis
… azoxymethane (AOM) was used to induce pre-neoplastic colonic lesions in male Fischer 344 rats. These pre-neoplastic lesions are termed aberrant crypt foci (ACF). Both ACF and ACF with multiplicity (ACF with four or more aberrant crypts within a focus) are putative pre-neoplastic lesions …
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High resolution imaging of neoplasma using optical coherence tomography
… and endoscopy. However, many early neoplastic changes remain beyond their detection limits. A modality capable of imaging at or near the cellular level could detect disease at earlier stages than currently possible and thus improve patient prognosis. Optical coherence tomography …
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Vacuolation, proliferation and neoplasia in the liver of Boston Harbor winter flounder (Pseudopleuronectes americanus)
… a major sewage outfall, and that the predominant neoplastic cell type was cholangiocellular. Cholangiocellular neoplasms ranged from non-invasive tubular cholangiomas to invasive anaplastic cholangiocellular carcinomas. The latter were solid, tubular, cystic and scirrhous in form. Hepatocellular …
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Polyclonal interactions in intestinal tumorigenesis
… with reports of polyclonality in a number of neoplastic lesions. In the first part of this thesis, I combine multicolour lineage tracing with a mouse model of intestinal tumorigenesis to show that a significant proportion of tumours have a polyclonal origin following the loss of one allele of …
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THE INTERACTION OF TRANSCRIPTION FACTORS WITH THE LONG CONTROL REGION OF HPV 16
… 16 (HPV 16) infects mucosal epithelia and causes neoplastic lesions that may progress towards cancer. A segment of 850 base pairs (bp) of the 7904 bp circular DNA genome of HPV 16 termed the long control region (LCR) does not contain genes but contains the control elements for transcriptional …
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Finding NEMO by the molluscum contagiosum virus MC159 protein and its effect on viral pathogenesis in vivo
… infects humans. MCV infections causes benign neoplastic lesions that can persists for few months in children and adults. It is an opportunistic infection in immunocompromised patients. Currently there is no FDA approved drug available for MCV infections. The knowledge of MCV pathogenesis is …
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PRECLINICAL PET IMAGING FOR TUMOUR CHARACTERIZATION: FOCUS ON HYPOXIA AND INFLAMMATION
… ([18F]FDG-PET) is widely used in neoplastic patients for disease assessment and evaluation of treatment efficacy. Results interpretation must take into account the contribution of inflammatory cells that infiltrate growing tumours for [18F]FDG uptake. In this work, we established a …
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DENDRITIC CELLS IN A MURINE MODEL OF BREAST CANCER: FUNCTIONAL AND PHENOTYPIC EVALUATION USING NANOPARTICLES
… loading. Tumoral antigens were obtained lysing neoplastic masses extracted from a mammary tumour mouse model (MMTV-Ha-Ras). DCs pulsed with different antigen concentrations resulted mature by means of high levels of activation and maturation markers. Moreover, such cells were able to stimulate T …
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Investigating the Fate of Pre-neoplastic Cells in a Mouse Model of Medulloblastoma
… as prostate, pancreatic, and colon cancer, a pre-neoplastic, or intermediate, stage of the disease has been identified. The pre-neoplastic stage is presumed to be a transition during which normal cells undergo malignant transformation. However, the link between the pre-neoplastic cells and …
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The role of neurofilament-light polipeptide (NEFL) in the onset and progression of hepatocellular carcinoma
… was strongly up-regulated in KRT-19 positive preneoplastic lesions and in fully malignant HCCs. In agreement with mRNA levels, immunofluorescence studies identified the neurofilament only in the preneoplastic lesions positive for KRT-19 and in early HCCs. Since the presence of this neurofilament …
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Anti-inflammatory and anti-colon cancer potential of yerba mate (Ilex paraguariensis St. Hilaire) bioactive constituents
… mate saponins on the development of colon pre-neoplastic lesions, aberrant crypt foci (ACF), in the azoxymethane (AOM)-induced model using male F344 rats. The animals received a basal diet and a mate aqueous extract (2% w/v) as drinking fluid, or mate saponins (0.01%, w/w) mixed with the basal …
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Biomimetic platforms for modeling in vitro the functional unit of the exocrine pancreas
… exocrine pancreas in vitro, where the earliest lesions of pancreatic cancer manifest. The objective of this work is to create advanced bioengineered platforms that mimic the intricate processes involved in the initial stages of tumor development. To achieve this goal, different biofabrication …