Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"neonatal rat"”.
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The ultrastructure and permeability of fetal and neonatal rat intestinal capillaries
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Perinatal Nicotine Exposure and Programming of HIE Sensitive Phenotype in Neonatal Rat Brains
… mechanisms. Therefore, we established two rat models: perinatal nicotine exposure model in time-dated pregnant rats; hypoxic-ischemic encephalopathy (HIE) in 10-day-old rat pups. In the first part of our study, we demonstrated that nicotine exposure induces aberrant brain development in P10 …
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Effect of Maternal Hypoxia on Fetal Development: Programming of HIE Phenotype in Neonatal Rat Brain
… will be evaluated. To address these issues two rats model were established: perinatal hypoxia exposure model in time-dated pregnant rats and hypoxic-ischemic encephalopathy in 10-day-old rat pups. Through these studies we found that maternal hypoxia decrease the number of glomeruli in offspring …
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Development of the neonatal rat as a model for Sudden Infant Death Syndrome: cardiorespiratory effects of ethanol
… The second study identified the cardiorespiratory responses to inhaled CO2 challenge in juvenile rats, to determine the age corresponding to the age range of peak incidence of SIDS in human infants. Finally, utilizing the optimized juvenile rat model, the cardiorespiratory responses to …
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Developmental Nicotine Exposure And Its Effects On Morphology And Electrophysiology Of Hypoglossal Motoneurons In The Neonatal Rat
… (DNE) is known to cause deleterious effects in neonatal mammals through nicotine's actions on nicotinic acetylcholine receptors (nAChRs). In this work, we studied how DNE altered the structure and function of the hypoglossal motoneurons (XIIMNs) over the first few days post-parturition. Previous …
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Expression and Function(s) of Parathyroid Hormone- Related Peptide in Intramembranous Bone Formation by Neonatal Rat Calvarial Cells In Vitro
The appearance of neonatal mice that develop in the absence of parathyroid hormone- related peptide (PTHrP) established that the peptide is necessary for normal development and growth of the skeleton. The shortening of appendicular bones in knockout mice is explained by an effect of PTHrP on …
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Bax-mediated coordination of cognate organelle cell death signaling cascades determines cell death phenotype after trauma in the neonatal rat cortex
… were investigated in in vitro and in vivo neonatal cortical models.\r\n\r\nIn vivo, hypoxia-ischemia (HI) induces a distinct subcellular time course for Bax in the neonatal cortex, localizing first to the nucleus, then to mitochondria and, finally, to the ER with Bax localization …
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Development of a Model System for Culturing Neonatal Rat Ventricular Myocytes in vitro to Monitor Integrin Activation in Response to Altered Contractile Force
… state. The interplay between the forces generated by the contractile apparatus and sensed by integrins is central to understanding the pathogenesis of HCM. Integrins are likely the mechanotransducers in cardiomyocytes, converting mechanical stress into chemical signals that stimulate cardiac …
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Preclinical Evaluation Of Infrared Light Therapy In A Rat Model Of Neonatal Hypoxic-Ischemic Encephalopathy
… oxygen availability are detrimental resulting in neonatal hypoxic-ischemic encephalopathy (HIE). This work focused on the characterization of a rat model of neonatal HIE for use in the preclinical evaluation of infrared light therapy (IRL). Consistent with results from previous IRL efficacy …
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Thyroid Hormone Effects on Sertoli Cell Gene Expression in the Rat
… as follicle stimulating hormone (FSH), regulate neonatal Sertoli cell development. It was not clear however, if all of the changes seen in Sertoli cell development during hypothyroidism represent direct effects of thyroid hormone deficiency on the Sertoli cells, or if some effects result from …
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Human Nav1.5 F1486 deletion associated with long-QT syndrome leads to deficiency in inactivation and reduces lidocaine sensitivity
… sodium channel α subunit Nav1.5 generates the cardiac sodium current, which is essential for the initiation and propagation of the cardiac action potentials. Mutations of SCN5A, the gene that encodes Nav1.5, have been well documented to cause long-QT syndrome (LQTs) by disrupting …
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THE VASCULAR RESPONSE WITHIN THE ISLET DURING BETA CELL DEVELOPMENT AND REGENERATION
… to develop into the appropriate cell type. The neonatal rat pancreas undergoes a developmental β cell turnover that involves the apoptosis of immature β cells and their replacement with adult β cells. To further elucidate this mechanism and the potential role of the vascular system, neonatal …
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Human neural stem cells: region-specific properties and prospects for cell therapy
… can, in animal models of neurodegenerative diseases, reconstruct damaged brain circuitry. In the clinical situation, the graft material used for cell therapy must, most likely, be of human origin. The human fetal brain is one potential source of neural stem cells (NSCs) for cell …
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Sub threshold high frequency electrical field stimulation effect for angiogenesis and vegf expression in cardiomyocytes and heart tissue. Remodelling in the heart: impact of mechanical stretch, threshold and sub-threshold electrical stimulation on cultivated cardiomyocytes and sympathetic neurons /
… endothelial growth factor regulation in cultured neonatal rat ventricular myocytes. To evaluate the role of autoantibodies in cases of dilated cardiomyopathy, inducing the expression of vascular endothelial growth factor in cardiomyocytes; to evaluate the effect of contraction and the secretion of …
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Serine 910 Phosphorylation of Focal Adhesion Kinase Is Critical for Costamere Assembly
… increase in FAK-S910 phosphorylation in neonatal rat ventricular myocytes (NRVM). FAK-S910 phosphorylation required ET<sub>A</sub>R-dependent activation of PKCδ and Src via parallel Raf-1→MEK1/2→ERK1/2 and MEK5→ERK5 signaling pathways. Using co-immunoprecipitation, TIRF-microscopy and …
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The Voltage Gated Sodium Channel β1/β1B subunits: Emerging Therapeutic Targets in the Heart
… at targeting the β1 subunit was with the generation of and treatment with an SCN1B Ig domain mimetic peptide βadp1. Here we describe further investigation into the function and mode-of-action of both βadp1 and novel peptides derived from the original βadp1 sequence. We find that in a …
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DYSREGULATION of PROTEIN QUALITY CONTROL IMPAIRS FUNCTION of PRIMARY CARDIOMYOCYTES
… species (ROS), by-products of mitochondrial respiration, within dysfunctional mitochondria results in the activation of cardiac cell death pathways and has been associated with heart failure development. Therefore, maintaining mitochondrial homeostasis as a balance between mitochondrial biogenesis …
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An investigation of some factors affecting transdermal permeation.
… Thermal Anlaysis (DTA) and in vitro penetration studies of neonatal rat stratum corneum (s.c.), with radiolabelled propanol and hexanol as penetrants. Thermogravimetric Analysis, Thin-Layer Chromatography (TLC) and Infrared Spectroscopy were used to provide additional information. DTA of …
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Development of 'In vitro' intestinal models to study the pharmacology of drugs affecting the gastrointestinal tract in normal and diseased conditions. Development of a cell culture model for intestinal pharmacology.
… of 5-HT receptors mediating a response in the neonatal intestine have been limited. There are evidences that the development of new neurones continues past postnatal term and this suggests that receptors expression may differ during maturation. Thus, `in vitro¿ experiments were carried out to …
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The influence of maternal nicotine exposure on development lung as gas exchanger: the protective effect of copper
… and lactation interferes with fetal and neonatal lung growth and development, rendering the lungs more susceptible to damage and disease. interference with the normal developmental processes at any stage may compromise the gas exchange function of the lungs. Maternal nicotine exposure …
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