Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"neonatal piglet"”.
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Early nutrition affects intestinal development and immune response in the neonatal piglet
… the effects of these early life events on neonatal intestinal, microbial, and immune development. Our first aim was to investigate the effect of route of delivery on microbial development and intestinal structure and function. Neonatal piglets were delivered either vaginally (VD) or by …
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Human milk oligosaccharide supplementation did not affect gut development in the healthy neonatal piglet
… but its effects in the gut of the healthy IUGR piglet are largely unknown. Objective: To investigate the effect of supplementation of HMOs in piglet formula on gut development in IUGR piglets. Methods: Appropriate for gestational age (AGA) and IUGR sex- and litter-paired piglets were weaned and …
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Oral Insulin-Like Growth Factor-I and Development of the Small Intestine in the Neonatal Piglet
… did not lead to an increase in overall piglet growth, we conclude that the effects of IGF-I in the normal, healthy neonate are modest. However, since IGF-I stimulates intestinal growth and development without undesirable systemic effects, it may be a beneficial therapeutic agent for …
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Effect of bovine lactoferrin on T lymphocyte cell phenotype and function and the response to vaccination in the neonatal piglet
… is disparate between formula-fed and sow-reared piglets and that addition of bLf would enhance vaccination response and T-cell function in formula-fed piglets. To address this hypothesis, two specific aims were undertaken. N Specific Aim 1 investigated the effect of bLf supplemented to infant …
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The effect of butyrate-supplemented total parenteral nutrition on muc2 mRNA and goblet cell chemotypes in a short bowel syndrome neonatal piglet model
… administration. Methods: Forty-eight hour old piglets underwent 80% proximal jejunuoileal resection and were randomized to one of four groups: control total parenteral nutrition (TPN), TPN supplemented with 60 mM SCFA (36 mM acetate, 15 mM propionate, and 9 mM butyrate; SCFA), 9 mM butyrate …
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In Vitro and in Vivo Modulation of Rotavirus Infection by Soy Isoflavones
… of rotavirus attachment to the host cells. The neonatal piglet model was used to test whether isoflavone could also modulate the severity and duration of rotavirus infections in vivo. As a first step, the temporal gastrointestinal host responses to rotavirus infection were established. Rotavirus …
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Modeling Neural Stem Cell Dynamics in Congenital Heart Disease
… to its reminiscent complexity to humans, the neonatal piglet (Sus scrofa domesticus), which possesses a highly evolved gyrencephalic neocortex and an expansive outer SVZ, provides a powerful translational model system for the study of how heart dysfunction impacts cortical development from …
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The effects of dietary protein source on the development of cholesterol metabolism
… of an earlier period in development using the neonatal piglet as a model showed that consumption of increasing proportions of whey protein decreased blood cholesterol concentrations (p $<$.05), and increased weight gain (p $<$.05). 100% casein consumption also decreased hepatic cholesterol …
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Route of Nutrient Administration Alters Intestinal Immune Cell Composition in Neonatal Piglets
… composition in the developing intestine. The neonatal piglet was used as the model for the human infant. In experiment 1, piglets receiving TPN for seven days demonstrated compromised intestinal morphology and a greater number of intestinal CD4+ and CD8+ T-lymphocytes, goblet cells, and mast …
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Development of Virus-like particles (VLPs) Based Vaccines Against Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) and Porcine Epidemic Diarrhea Virus (PEDV)
… a comprehensive pregnant gilt vaccination and neonatal piglet challenge model. The vaccine candidate incorporated B-cell epitope 748YSNIGVCK755 from the PEDV spike protein. It was able to elicit significant viral neutralization antibody titer in gilt milk at 3 days post-farrowing (DPF), and …
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Effect of colostrum supplementation on baby pig performance
… on the performance and immune response of baby piglets. In Exp. 1, 301 newborn pigs (Line 600 × 241; DNA, 1.48 kg) were used in a 21-d study. Pigs were weighed and allotted to one of three treatments at 6-h of age in a randomized complete block design with 23 replications (litters) per …
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Development of in vitro infant intestinal models to assess responses to infant formulae
… maturation are intimately linked, with the neonatal gut characterized by higher permeability than in adults. The aim of this thesis was to develop and validate in vitro models that mimic the infant intestinal barrier. Once developed, these models were employed to study epithelial responses …
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Neuroimmune origins of behavioral disorders
… is to delineate the activity of prenatal and neonatal microglial cells during and immediately following maternal infection, using a highly-translatable swine model. The investigations undertaken to obtain this goal are divided into three major sections within this dissertation. First, we …
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Engineering solutions to address several current livestock and poultry housing challenges
… include: 1) high pre-weaning mortality of neonatal piglets in typical farrowing swine facilities, 2) maintaining egg production and sufficient well-being for laying hens under heat stress events, and 3) compromised air quality issues in most poultry housing systems. My research seeks to …
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Lactoferrin in neonatal development: effects on intestinal structure and intestinal function and immune response in a piglet model of systemic Staphylococcus aureus infection
… infection, urinary tract infections and neonatal sepsis (Stuebe 2009; Golding et al 1997). The difference in health outcomes observed between breast-fed and formula-fed infants is in part explained by immune factors present in human milk that provide specific and innate immune factors …