Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"neonatal development"”.
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Lactoferrin in neonatal development: effects on intestinal structure and intestinal function and immune response in a piglet model of systemic Staphylococcus aureus infection
… infection, urinary tract infections and neonatal sepsis (Stuebe 2009; Golding et al 1997). The difference in health outcomes observed between breast-fed and formula-fed infants is in part explained by immune factors present in human milk that provide specific and innate immune factors …
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The Angiotensin Receptor (AT₁) Inhibitor, Losartan, Slows Post-Natal Thickening of the Left Ventricle
… a role for a cardiac RAS in left ventricular development by giving losartan, an angiotensin IT (AII) AT; receptor antagonist to pregnant rats. Hearts were removed from neonates, fixed and cryosections cut with litter-mates being similarly processed at 24 hour intervals. Micrographs were …
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ALK in the pathogenesis of cancer
… expression is limited to neuronal cells during neonatal development, although resistance to ALK-targeted therapy has been observed. In this thesis I explore potential mechanisms of resistance to the ALK inhibitors that have been approved for ALK+ non-small cell lung cancer (NSCLC) including …
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Cytoarchitectural Defects Secondary To Experimentally Induced Oligodendrocyte Death In The Adult And Developing Central Nervous System
… between axons and oligodendrocytes has been the development of models in which oligodendrocytes can be experimentally eliminated from living tissues. However, confounding factors inherent in each of the existing models complicate data interpretation. Limitations include dubious cell specificity, …
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The physiological significance of insemination in programming pregnancy outcome
… success and optimal fetal and placental development. Perturbations to this environment not only have consequences for the success of pregnancy and neonatal health and viability, but can also drive adverse health outcomes in the offspring after birth, particularly the development of …
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Leptin and peroxisome proliferator activated receptor alpha: understanding their contribution towards normalising the programmed phenotype in the peripheral tissues of IUGR offspring
… a high calorie postnatal diet and reversed by neonatal leptin treatment. Evidence is now accumulating which indicates that altered epigenetic regulation and gene expression may underpin the relationship between the early life environment and metabolic disturbances in adult life. Therefore, to …
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Assessment of Physiological Challenges in Overwintering Black Bears (Ursus americanus): Active Gestation, Neonatal Growth, and Skeletal Muscle Conservation
… Also, there is little known about postnatal development of cubs or the influence of maternal traits on embryonic implantation and cub growth. Finally, the role of satellite cells (SCs – stem cells able to regenerate muscle fibers) play in maintaining muscle functionality during hibernating …
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A computational approach to understanding maternal influences on the development of ruminant neonates
… which help the newborns to bypass this critical developmental period. While the detrimental effects associated with the failure of passive transfer of colostral immunoglobulins on neonatal immunity and disease susceptibility are well established, the influence of colostral cells on neonatal …
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The Effects of Neonatal Immune System Activation with Lipopolysaccharide on Adolescent and Adult Anxiety Behaviours in Male and Female Rats
The present study examined the effects of neonatal (postnatal days 3 and 5) acute immune system activation with lipopolysaccharide (LPS) on adolescent and adult anxiety behaviours. The major findings suggest that neonatal LPS does not have general long-lasting effects on adolescent anxiety and …