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Showing 1 to 20 of 31 for “"neointima"”.

  1. Characterization of the Mechanism of PPARγ-Mediated Neointima Formation in Rodents

    Tsukahara, Ryoko2016

    … the LPA receptor subtypes necessary for the neointimal response in a non-injury model of carotid remodeling and also compared the effects of AGP and the PPARγ agonist rosiglitazone (ROSI) on balloon injury-elicited neointima development. In the balloon injury model AGP significantly increased …

    tenn-hsc Repository record

  2. Vergleichende Untersuchung der Wirkung verschiedener HMG-CoA Reduktase Inhibitoren auf die Apoptose normaler und neointimaler Gefäßmuskelzellen

    Hristov, MihailLudwig-Maximilians-Universität

    … selektive Induktion von Apoptose in Zellen der Neointima zur Restenose-prävention ist ein besseres Verständnis der Apoptoseregulation in glatten Gefäßmuskelzellen erforderlich. In dieser Arbeit wurden glatte Gefäßmuskelzellen aus Media und Neointima der Ratte im Hinblick auf ihre Empfindlichkeit …

    lmu-germany Repository record

  3. Untersuchungen zur Beteiligung von p38 MAPK beim Remodelingprozeß nach Myokardinfarkt in vivo und bei der Fibronektinexpression in Rahmen der Neointima - Entstehung nach Angioplastie in vitro

    Berova, Marinela GueorguievaUniversität Würzburg

    … und bei der Fibronektin-Expression in Rahmen der Neointima- Entstehung nach Angioplastie in vitro durchgeführt. Im Bereich der kardiovaskulären Forschung hat die Familie der Mitogen Aktivierten Protein Kinasen besonderes Interesse gewonnen. Sie besteht aus drei Subgruppen - JNK, ERK und p38 MAPK. …

    wurz-thes Repository record

  4. Die Auswirkungen vom 188-Rhenium-Stents auf Neointimadicke, Stenosegrad und histologische Parameter in der Gefäßwand im Schafmodell

    Geiter, Klaus UlrichPublikationsserver der RWTH Aachen University2009

    … radioactive self-expanding 188-rhenium stents on neointimal formation as well as on the percent area stenosis and the histological parameter endothelialization, oedema, apoptosis, inflammation, thrombosis and the grade of smooth muscle cells in the neointima. We implantated thirty stents, 15 of …

    aachen Repository record

  5. Prospektive randomisierte Untersuchung der Neointimaproliferation in goldbeschichteten Koronarstents im Vergleich zu herkömmlichen Edelstahlstents mittels intravaskulären Ultraschalls

    Dechêne, AlexanderPublikationsserver der RWTH Aachen University2005

    … coronary interventions and occurs due to neointimal hyperplasia after stent implantation. Gold coating of stainless stell stents showed an in-vitro-reduction of neointimal formation, an effect attributed to an assumed favourable biocompatibility and reduced thrombogenicity of the element …

    aachen Repository record

  6. A translational approach to understanding cellular responses to vascular injury

    Sedovy, MeghanVirginia Tech2025

    … drove excessive proliferation leading to neointima formation and vascular blockage. A Johnstone lab developed peptide that targets this phosphorylation state prevents neointima formation in mouse and human tissues. These findings highlight a role for Cx43 phosphorylation by MAPK in …

    vt Repository record

  7. Vascular smooth muscle cell heterogeneity and plasticity in models of cardiovascular disease

    Chappell, JoelUniversity of Cambridge2018

    … used to demonstrate that VSMCs in injury-induced neointimal lesions and in atherosclerotic plaques are oligo-clonal, derived from few expanding cells, within mice. Lineage tracing also revealed that the progeny of individual VSMCs contribute to both alpha Smooth muscle actin (aSma)-positive …

    cambridge Repository record

  8. Polo-Like Kinase 1 and Smooth Muscle Cells in Coronary Artery Bypass Conduits and Coronary Arteries Following Angioplasty

    Sur, SwastikaCreighton University2016

    … (SV) graft is prone to undergo restenosis due to neointima formation. However, the underlying mechanism in vein-graft that makes it prone to stenosis and closure is unknown. In this study, we examined the role of polo-like kinase (PLK)-1 in the PLK1/pPLK1-pCDK1-p-Histone H3 pathway in mediating …

    creighton Repository record

  9. In Vitro and In Silico Study of Deposition on Textured Biomaterials: Towards Biofunctionalization of Ventricular Cannula

    He, WenxuanCornell University2025

    … decades have been highly variable, ranging from neointima to thrombus. Chapter 2 addresses this ambiguity by introducing a unified taxonomy for biological response to sintered titanium in LVADs, distinguishing neointima---with anti-thrombogenic endothelium--- from pannus, pseudoneointima, and …

    cornell Repository record

  10. Einfluß der Atherosklerose auf den NO:cGMP Signalweg am Modell des cholesteringefütterten Kaninchen

    Melichar, Volker O.Universität Würzburg

    … ist vor allem in der neugebildeten Neointima reduziert. P-VASP, ein Indikator der Aktivität des gesamten NO:cGMP-Signalwegs, ist in eindrucksvoller Weise reduziert. Die Enzyme des NO-unabhängigen Teils des NO:cGMP-Signalwegs werden in zunehmenden Maße pharmakologisch beeinflußbar. …

    wurz-thes Repository record

  11. Die Bedeutung von Entzündung und reaktiven Sauerstoffspezies in der Intimahyperplasie

    Kamann, StefanieUniversität Potsdam

    … des Gefäßes ist die Bildung einer Neointima durch die Proliferation transdifferenzierter vaskulärer glatter Muskelzellen und die Sekretion extrazellulärer Matrix. Die Entstehung reaktiver Sauerstoffspezies (ROS) und die Entzündungsreaktion nach der Gefäßverletzung werden als frühe, …

    potsdam-diss Repository record

  12. Protective Immunity in Atherosclerosis

    Wigren, MariaExperimental Cardiovascular Research Unit, Lund University2011

    … reduced atherosclerosis development, whereas, neointima formation in response to vascular injury was accelerated by CD1d lipid antigen presentation. NKT cells and CD1d could therefore be an additional potential target in immune modulating therapies. Except for novel therapies, new biomarkers to …

    lund Repository record

  13. Studies on the role of the endocannabinoid anandamide, as a possible modulator of events during neointimal formation.

    Skene, Karen E.Robert Gordon University2010

    Neointimal formation is a complex process that occurs due to the over compensatory healing response produced by the vessel following injury. Three key events, SMC proliferation, SMC migration and the inflammatory response, occur in unison to drive the formation of a neointima. …

    rgu Repository record

  14. Der Einfluss von N-Cadherin auf die Migration glatter Gefäßmuskelzellen im Rahmen der Restenoseentstehung

    Stein, JuliaPublikationsserver der RWTH Aachen University2008

    … restenosis model revealed downregulation in the neointima after 14 days. After 28 days, N-cadherin expression was slightly restored, while after 90 days, no difference between medial and neointimal expression was detectable. During the whole period beta-catenin levels remained unchanged. …

    aachen Repository record

  15. Novel strategies for optimising drug release from medicinal implants

    Galluzzo, AnnaUniversity of Strathclyde2012

    … and migration, resulting in the development of a neointima, which renarrows the artery lumen. Drug-eluting stents (DES) release drugs to inhibit SMC proliferation and have been very successful in reducing ISR rates. However, they are not suitable for every patient group and lesion type, and may …

    strathclyde Repository record

  16. Vascular Endothelin and Angiotensin Receptors Regulation in Inflammatory Arterial Disorders

    Dimitrijevic, IvanDepartment of Internal Medcine, University Hospital of Lund,2010

    … in the VSMC in the medial layer as well in the neointima in affected arteries. 6. ETB receptors mediate contraction of subcutaneous resistance arteries in ischemic heart disease. The present thesis demonstrated that there is increased ETB and AT1 receptor expression in VSMC in ischemic heart …

    lund Repository record

  17. Einfluß der Photodynamischen Therapie auf die Neointimabildung vor und nach Stentimplantation in die Arteria femoralis des Hausschweines

    Valassis, GrigoriosLudwig-Maximilians-Universität

    … um einen möglichst günstigen Effekt auf die Neointimafläche zu erzielen. Material und Methode: Es wurden drei Gruppen untersucht. Die Kontrollgruppe (Gruppe K), bei der jeweils ein Stent in die Arteria femoralis implantiert wurde, eine „1.Stent+2.PDT“-Gruppe (Gruppe A), die zuerst einer …

    lmu-germany Repository record

  18. Hochfrequenzrotablation zur Behandlung von Restenosen in Koronarstents

    Kastrau, FrankPublikationsserver der RWTH Aachen University2004

    … used, indicating an immediate recoil of the neointima. An additionally performed BA led to a further decrease in the area of stenosis to 22±13% due to an expansion of the stent. The angiographic follow-up showed a recurrent restenosis rate of 45%, thus indicating the need for a target …

    aachen Repository record

  19. Evaluation eines Tacrolimus-beschichteten Stents zur Prävention der Restenosierung im diabetischen Tiermodell

    Mandapathil, Magis MathewPublikationsserver der RWTH Aachen University2008

    … ± 6% vs. 31 ± 10%, p=0,05). The average rate of neointimal formation tended to be lower in the BMS group in comparism to the TES group (0,88 ± 0,32mm² vs. 1,13 ± 0,31mm², p=0,11). The average number of macrophages in the neointima was significantly decreased in the TES as compared to the BMS …

    aachen Repository record

  20. Spatiotemporal controlled delivery of nanoparticles to injured vasculature

    Chan, Juliana MariaMassachusetts Institute of Technology2010

    … on Day I and 6 and resulted in lower neointima-to-media (N/M) scores at two weeks compared to FDA-approved Taxol@ and injury-only groups (N/Msham= -249 + 0.046, vs. N/MTaxol=0.837 ± 0.087, N/MNP=0.749 ± 0.136 and N/MPep-NP=0.662 ± 0.169, all P < 0.01 vs. injury-only, mean ± SEM, n=5). …

    mit Repository record

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