Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"neocortical development"”.
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Proneural Genes in Neocortical Development
The timing of neocortical development is regulated by both intrinsic proneural genes Neurog2 and Ascl1, and extrinsic signals. However, how these intrinsic factors and extrinsic signals coordinatedly control neural cell fate decisions was not well understood at the start of my studies. Neurog2 and …
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ADDUCINS AFFECT CORTICAL NEUROGENESIS BY REGULATING PROGENITORS¿ MORPHOLOGY AND FATE
… main reason for this change can be found during neocortical development in an increased neuronal production during a prolonged neurogenic period. Neocortical development starts during embryogenesis with the main neural progenitor cells, classified as apical (APs) and basal progenitors (BPs). BPs …
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Transcriptional Regulation of Neuronal Fate Specification by Proneural Genes in the Developing Neocortex
… are generated in a strict temporal order during development. One class of intrinsic determinants that control the timing of cortical neurogenesis are the proneural basic helix-loop-helix (bHLH) transcription factors encoded by Neurog1, Neurog2, and Ascl1. The activities of these proneural genes …
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The impact of viral infection during pregnancy on maternal immunity and fetal brain development
Neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD) and schizophrenia, are rising in prevalence, yet their etiology and underlying mechanisms remain largely elusive. Epidemiological studies implicate influenza A virus (IAV) infection during pregnancy as a risk factor for …
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Quantitative spatial transcriptomics of the developing brain
Developmental and cellular heterogeneity can be studied at the transcriptomic level using RNA sequencing methods, but techniques that quantitatively investigate the spatial dynamics of cell heterogeneity across large tissue areas at a single-cell level are lacking. Applying this capability to the …
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Analysis and functional characterization in embryonic mouse neocortex of a set of human-specific genes expressed in neural progenitor cells of fetal human neocortex
Einführung: Eine entscheidende Ursache für das Aufkommen der den modernen Menschen charakterisierenden kognitiven Funktionen ist in der beachtlichen Vergrößerung des menschlichen Neocortex innerhalb der letzten 5-7 Millionen Jahre zu finden. Die Identifizierung der dieser Entwicklung zu Grunde …
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Die Funktion von Geminin beim Übergang von Neuro- zu Gliogenese in der Maus
Die Entwicklung eines Embryos bedarf der präzisen Kontrolle von zeitlich und räumlich koordinierten Prozessen, die das Schicksal der Zellen regulieren. Geminin wurde als bifunktionales Protein charakterisiert, welches sowohl bei der Regulation der Entwicklung des Nervensystems wie auch bei der …