Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"neoblasts"”.
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Neoblast specialization during regeneration of the planarian S. mediterranea
… requires a population of dividing cells called neoblasts that are distributed throughout the body. Historically, neoblasts have been considered a homogeneous population of stem cells capable of differentiating into all cell types. Most studies, however, analyze neoblasts at the population rather …
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How, when, and where: fate selection in regenerative planarians
… factors (FSTFs) in dividing cells called neoblasts. However, it remains unclear whether all ~150 fate choices are made in neoblasts, or whether additional mechanisms for generating cell type diversity are used. We used single-cell RNA-sequencing of S/G2/M neoblasts and early post-mitotic …
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From coarse fate choice to precise pattern: post-mitotic progenitor targeting
… driven by pluripotent stem cells called neoblasts. While neoblasts are known to give rise to progenitor cells that form various tissues, whether and the extent to which these progenitors migrate across the animal remains unclear. Irradiation experiments eliminate all neoblasts outside …
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Functional Studies of Stem Cells in the Parasitic Flatworm Schistosoma mansoni
… they possess somatic stem cells referred to as neoblasts, and they are incredibly successful parasites. Until now, there has been little appreciation for the interrelationships between the tegument, neoblasts, and successful parasitism. Our recent work, however, suggested that schistosome …
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Mechanisms of tissue-specific regeneration in planarians
… pluripotent population of dividing cells called neoblasts, which are required for homeostatic maintenance and regeneration of all planarian tissues. Whether neoblasts restore proportion by sensing and responding to the presence or absence of specific tissues during regeneration is unknown. We …
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Functional Analysis of Genes Involved in Regulating Stem Cell Maintenance and Differentiation in the Freshwater Planarian Schmidtea Mediterranea
… regenerative abilities of planarians rely on neoblasts, adult stem cells maintained throughout the animal's life. This thesis reports an analysis of genes that regulate stem cell maintenance and differentiation in planarian Schmidtea mediterranea. A member of the Bruno-like family of RNA …
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Identification of pluripotent stem cells and characterization of glia in the planarian Schmidtea mediterranea
… to be characterized. Although it is known that neoblasts, the population of all proliferative cells in the adult planarian, are the source of new tissue during regeneration, it is unknown whether neoblasts consist of multiple subpopulations of lineage-restricted multipotent stem cells or if …
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Organizer regeneration and patterning of stem cell lineages in planarians
… in planarians involves two important components. Neoblasts are pluripotent stem cells that are the source of all new cells during regeneration. Position control genes (PCGs) are developmental signaling genes that are constitutively expressed in adult planarian muscle, and are thought to provide …
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Regulation of fate specification in stem cells of the planarian Schmidtea mediterranea
… for producing a wide array of cell types. Neoblasts are stem cells of the planarian Schmidtea mediterranea that undergo fate specification to produce over 125 adult cell types. Fate specification in neoblasts can be regulated through expression of fate-specific transcription factors. We …
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Branching out: how a planarian neoblast generates cellular diversity
… population of pluripotent stem cells called neoblasts. Neoblasts are a heterogenous population of stem cells that begin unspecified, but are rapidly specified within a single cell cycle and give rise to every cell in the animal. In this work, we characterize the different types of specified …
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Cellular and genetic mechanisms of new tissue production in the regenerating planarian Schmidtea mediterranea
… biology in which proliferating cells known as "neoblasts" provide the source of new cellular material for regeneration. Stem cells that might be present within the neoblast population, however, have not yet been defined. Such cells could therefore be either pluripotent or, alternatively, a …
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Post-genomic studies on the neuropeptide signalling system of Juvenile <i>Fasciola hepatica</i>
… with the localisation of proliferating cells, or neoblasts, supports a potential link between NPF signalling and neoblasts. Significant improvements have been made to an existing chromogenic in situ hybridization (CISH) protocol to include a more sensitive fluorescent version. Overall, through …
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The instructive roles of muscle cells in planarian regeneration
… maintain tissue homeostasis. Dividing cells, neoblasts, are the source of all new tissue, whereas positional information is hypothesized to be harbored by post-mitotic muscle, including the subepidermal body wall musculature. Single-muscle-cell mRNA sequencing along the anterior-posterior axis …
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Regeneration and maintenance of the planarian nervous system
… on a population of cells in the adult, the neoblasts, that includes pluripotent stem cells. Whether the neoblast population also includes progenitors specialized for forming specific lineages has not been demonstrated. This thesis describes the identification of progenitors that contribute …
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Comprehensive single-cell transcriptional profiling of the regenerative planarian Schmidtea mediterranea
… possess a population of dividing cells, called neoblasts, which contain pluripotent stem cells and are the source of all new tissue, with all cell types being turned over throughout the life of the animal. Planarians also constitutively express an arrangement of regionally expressed genes in …
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Genetic regulation of neuronal stem cell differentiation: a single-cell sequencing study in planarians
… of somatic pluripotent adult stem cells: the neoblasts. However, the genetic networks that drive the differentiation of planarian adult stem cells into the neural lineage are still unknown. Here we show that single-cell expression profiling technologies allow disentangling neuronal …
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Dissecting the molecular mechanisms of germ cell development in the planarian Schmidtea mediterranea
… to form their germline post-embryonically from neoblasts, the totipotent stem cells of the species. In this study, we aim to systematically investigate germ cell development in planarian species Schmidtea mediterranea. We first identified a S. mediterranea homolog of the conserved early germ …
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An insulin-like peptide regulates size and adult stem cells in planarians
… the planarian adult stem cell population (neoblasts) and the germline. Both impaired insulin signaling and nutritional deprivation correlate with decreased neoblast proliferation. Additionally, insulin signaling plays a role in supporting spermatogenesis that is distinct from the effects of …
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Probing the biology of liver fluke-flukicide interplay
Fasciolosis, caused by liver fluke parasites of genus Fasciola, is responsible for reducing global agricultural yield in livestock animals and is a neglected tropical disease of humans. A limited portfolio of flukicide drugs are available, however treatment of the highly pathogenic acute stage is …
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Liver fluke development: a target for parasite control?
Fasciolosis, a debilitating disease caused by flatworm parasites belonging to the genus Fasciola, is a prominent threat to global food security due to its widespread infection of agriculturally significant ruminants. Recent studies have identified a population of proliferative cells within Fasciola …