Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"neoadjuvant chemotherapy"”.
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Morphological quantitation software in breast MRI: application to neoadjuvant chemotherapy patients
… textural analysis in predicting response to chemotherapy in a cohort of breast cancer patients. In addition an attempt was made to use shape parameters in order to assess tumour surface irregularity, and as a predictor of response to chemotherapy.In further work this study aimed to texture …
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Body mass index and response to neoadjuvant chemotherapy in Korean breast cancer
BACKGROUND AND OBJECTIVES: The relationship of neoadjuvant chemotherapy(NAC) and body mass index (BMI) in patients with breast cancer have been reported in many studies. According to many studies, poor prognosis is associated with obesity in western breast cancer patients, but not in oriental …
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Predicting Response to Neoadjuvant Chemotherapy in Breast Cancer with Gene Expression and Computational Pathology
Many breast cancer patients are treated with chemotherapy before surgery for the removal of the tumour, which is known as neoadjuvant chemotherapy (NAT). It improves outcome for many patients, and their response to the treatment is prognostic for their overall outcome. However, not all patients who …
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The clonal architecture and tumour microenvironment of breast cancers are shaped by neoadjuvant chemotherapy
Neoadjuvant chemotherapy has become standard practice in patients with high-risk early breast cancer as it improves rates of breast conservation surgery and enables prediction of recurrence and survival by using response to treatment as a surrogate. Previous studies have focused on generating …
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Predictive factors of stable or progressive disease during anthracycline with/without taxane-based neoadjuvant chemotherapy in breast cancer
Purpose: Neoadjuvant chemotherapy (NAC) has been shown to effectively downstage locally advanced breast cancer; however, clinically, no response or a progression of the tumor can occur in some cases. Predictive factors of no response or progression are unknown compared to predictive factors of a …
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Comparison of two neoadjuvant chemotherapy in locally advanced breast cancer patients; Adriamycin and Docetaxel (AD) versus Adriamycin, Cyclophosphamide followed by Paclitaxel (AC-T)
BACKGROUND: Neoadjuvant chemotherapy (NAC) is one of the standard treatmentfor the patients with locally advanced breast cancer and is an option for the patients with operable breast cancer. Such as adjuvant chemotherapy in breast cancer, anthracycline and taxane-based regimens have been studied …
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Pathological response of breast cancer to neo-adjuvant chemotherapy at a single tertiary centre with no access to Trastuzumab
Introduction: Neoadjuvant chemotherapy (NACT) has firmly solidified its status as the gold standard in the treatment of breast cancer for eligible patients. While prevailing guidelines advocate for a combined approach involving chemotherapy and Trastuzumab for individuals with HER2-positive breast …
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Nuclear Basic Fibroblast Growth Factor Regulation of Triple-Negative Breast Cancer Dormancy/Recurrence
<p>Chemotherapy remains the only available treatment for triple-negative (TN) breast cancer. Although some TN breast cancers respond initially to neoadjuvant chemotherapy, the majority of patients die within three years of treatment due to recurrent tumor growth. Developing ex vivo models for TN …
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Multi-Modality Plasma-Based Detection of Minimal Residual Disease in Triple-Negative Breast Cancer
… who are technically “disease-free” after neoadjuvant chemotherapy and surgery as early as possible might be able to predict recurrence of patients, and then provide timely intervention for additional therapy. To this end, I applied the analysis of “liquid biopsies” for early detection of …
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Dynamic Digital Optical Tomography for Cancer Imaging and Therapy Monitoring
… study monitoring individual patient response to neoadjuvant chemotherapy. These studies show that diffuse optical tomography is a valuable imaging modality that can play an important role in cancer detection and treatment.
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Proteomic identification of putative biomarkers of neo-adjuvant chemotherapy resistance in luminal (ER+) breast cancer
Background:Neoadjuvant chemotherapy is a standard treatment for locally advanced breast cancer however chemoresistance can be a major obstacle in ER+ cancers. Using comparative proteomic approaches (antibody microarray/AbMA and 2D-PAGE with MALDI-TOF/TOF MS) to investigate a pilot series of breast …
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Influence of molecular and genetic factors of the organism΄s antioxidative system on cervical carcinogenesis and the role of these factors in treatment of locally advanced cervical cancer /
… of locally advanced cervical cancer by means of neoadjuvant chemotherapy and chemoradiotherapy. In our study significant differences in blood serum levels of GSH and GST in patients with locally advanced cervical cancer, women with cervical intraepithelial lesions and healthy women demonstrated …
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Genomic Evolution of Chemoresistance In Triple-Negative Breast Cancer Delineated By Single Cell Sequencing
… and frequently (46%) develops resistance to neoadjuvant chemotherapy (NAC). Currently, the genomic basis of chemoresistance remains poorly understood. An important question is whether resistance to chemotherapy is driven by the selection of rare pre-existing subclones with genomic mutations …
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Neoadjuvant endocrine therapy for estrogen receptor positive breast cancer in an African setting
… response rates for ER positive cancers on neoadjuvant endocrine therapy (NET), with lower toxicity compared to neoadjuvant chemotherapy (NCT). During the first wave of the COVID pandemic, clinician preference for NET increased significantly, buying time for hospital recovery before …
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Quantitative Ultrasound Characterization and Monitoring of Locally Advanced Breast Cancer
… tumour-bearing mice, using human mimicking chemotherapy drugs. Treatment-related changes in quantitative ultrasound (QUS) parameters, including change in average acoustic concentration (AAC) and heterogeneity index, revealed a strong correlation to histologically determined cell death extent …
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Molecular Determinants of Residual Disease In Ovarian Cancer
… cytoreductive surgery followed by adjuvant chemotherapy. Residual disease followed by surgery is associated with adverse overall and progression-free survival as well as poor response to adjuvant chemotherapy. Accurate identification of patients at high risk of residual disease will help …
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Investigating The Rare Aneuploid Cells in Normal Breast and Therapeutic Resistance in Triple Negative Breast Cancer Using Single Cell Genomics
… subtype that is frequently treated with chemotherapy, but only half of the patients have a complete response. Here, we performed single cell transcriptomic analysis of 427,857 cells from treatment-naïve samples of 101 patients with TNBC treated with neoadjuvant chemotherapy. We classified …
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A multimodal breast cancer imaging system using coregistered dynamic diffuse optical tomography and digital breast tomosynthesis
… imaging method for breast cancer diagnosis and neoadjuvant chemotherapy monitoring. In particular, the multimodal approach of combining DOT with x-ray digital breast tomosynthesis (DBT) is especially synergistic as DBT prior information can be used to enhance the DOT reconstruction. DOT, in …
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