Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"nelfinavir"”.
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Synthesis of proteasome inhibitors: analogues of nelfinavir
Nelfinavir 1 has been found to be a very successful nonpeptidic HIV-protease inhibitor. According to a previous investigation, nelfinavir 1 proved to have an inhibitory effect on chymotrypsin-like activity of 20S proteasome. Previous studies also show the promotion of acceleration of the apoptosis …
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Plasma concentrations of nelfinavir and viral suppression in HIV-1 infected pregnant women
… reducing risk of vertical HIV-transmission. Nelfinavir(NFV) containing HAART has been highly used in pregnancy, but dosages may be inadequate due to the physiologic changes that occur. Given concerns regarding optimal viral suppression in pregnancy, drug toxicity and resistance development, …
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Stimulating antibiotic development by targeting virulence and facilitating natural product discovery
… that the FDA approved HIV protease inhibitor nelfinavir can be repurposed as an inhibitor of the biosynthesis of the Streptococcus pyogenes cytolytic toxin streptolysin S. Nelfinavir was utilized to explore the proteolytic processing step in streptolysin S biosynthesis and was also shown to …
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Role of cytochrome P450 enzymes on alcohol/nicotine-mediated oxidative stress and cytotoxicity in monocytes/astrocytes: Implications for HIV-infected alcohol/tobacco users
… to increased production of ROS, 3) CYP3A4 binds nelfinavir and other protease inhibitors (PI) and is inhibited by these PIs, 4) In both U937 monocytes and SVGA astrocytes, CYP2A6 is regulated by alcohol through oxidative stress-induced PKC/MEK/Nrf2 pathway, while CYP2E1 is regulated by oxidative …
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Prescribing patterns of antiretroviral drugs in the private health care sector in South Africa : a drug utilisation review
… all three-four month periods of 2002 and 2004. Nelfinavir has the highest average cost for period January to April of 2001, ritonavir for period May to August of 2001, and saquinavir mesylate for period September to December of 2001. Nelfinavir has the highest average cost for all three-four …
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Die Bedeutung der Proteasehemmer-Plasmakonzentration für das Lipodystrophiesyndrom bei Patienten mit HIV-Infektion unter HAART
… (RTV), Saquinavir (SQV), Indinavir (IDV) und Nelfinavir (NVF) sowie den neueren Substanzen Amprenavir und Lopinavir, die in Kombination mit Substanzen der Nukleosidischen- (NRTI) und Nicht-Nukleosidalen-Reverse-Transkriptase-Inhibitoren (NNRTI) eingenommen werden. Nach Einführung einer solchen …
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PHYTOCHEMICAL AND SYNTHETIC INVESTIGATIONAL COMPOUNDS AS MODULATORS OF CYTOMETABOLIC AND CYTOSKELETAL DYNAMICS FOR PRE-CLINICAL TARGETING OF PROSTATE CANCER
… lignan’s and other investigational drugs (nelfinavir, piperlongumine, and ursolic acid) mechanisms of actions can be clarified and used as putative therapeutic targets for prostate cancer. In summary this thesis provides evidence to support the ideas that: a) PC cells differentially utilize …