Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"neglected tropical disease"”.
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Canada's Contribution to Neglected Tropical Disease Research: A Co-authorship Network Analysis
… NTDs are a group of thirteen communicable diseases that thrive in impoverished settings and are a prime example of a global health issue in need of collaborative research solutions. The aim of this study was to design and apply an accessible yet systematic approach for analyzing the …
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If you build it, they will run : the role of clinical trial infrastructure in neglected disease R&D
… on research and development (R&D) levels for neglected tropical diseases concentrated in those countries. Pre-existing clinical trial infrastructure in a location can affect the cost and time of clinical trials carried out there, thus influence returns on investments for diseases that are …
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Impact of the parasitic helminth Schistosoma mansoni on host anti-viral vaccine responses: proof of concept from the anti-polio vaccine
Schistosomiasis is a devastating and neglected tropical disease caused by Schistosoma spp. parasites. The disease remains greatly neglected by global health control programmes thus classified as a top neglected tropical disease of humankind. One of the most common species of these parasites, …
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Me and My Monsters: A multispecies study on schistosomiasis in Sub-Saharan Africa
… are parasitic blood-fluke worms and their disease, schistosomiasis, is an ancient disease that has evolved with humans for centuries and it is through its connections to humans that it has thrived. This dissertation outlines the actor-network surrounding schistosomiasis through a …
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Identification of Leishmania tropica and Leishmania aethiopica by DNA sequencing and the detection of Leishmania RNA Virus
Leishmaniasis is a neglected tropical disease and a major cause of morbidity and mortality in impoverished countries. Leishmaniasis is a global disease and is clinically and epidemiologically diverse, with many different species of Leishmania affecting humans. The aim of this study was to …
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Dendritic cell regulation of immunity to Leishmania donovani
… of the immunological mechanisms underlying this disease is critical for the development of effective novel interventions. Phenotypic and functional analysis of CD11chi conventional dendritic cell subsets (cDCs) revealed widespread alterations as a result of chronic infection in the murine spleen. …
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Understanding the composition and function of the flagellar groove in bloodstream form Trypanosoma brucei
African Trypanosomiasis is a neglected tropical disease caused by the Trypanosoma brucei parasite and is transmitted by the bite of an infected tsetse fly. A characteristic feature of the bloodstream from of T. brucei is the flagellum, which is laterally attached to the side of the cell body and is …
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Cysteinyl leukotriene receptor 1 as a host determinant for susceptibility to cutaneous leishmaniasis in a mouse model
Leishmaniasis is a vector-borne neglected tropical disease caused by Leishmania parasites. Approximately one million Leishmania infections are reported annually with one billion people residing in 98 countries at risk of infection. Cutaneous leishmaniasis (CL), characterized by skin lesions caused …
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Presentation and management of snakebite envenomation in the uMkhanyakude district of KwaZulu-Natal (Mosvold Hospital)
Background. Snakebites have been recognized as a neglected tropical disease by the World Health Organization (WHO) since 2009, and in 2017, was elevated to category A. South Africa (SA) has a well documented prevalence of snakebites, and there has been a recent surge in attention due to dwindling …
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Quantifying the role of lymphatics in lipid transport and lymphatic filariasis using novel engineering approaches
… dysfunction has been implicated in a variety of diseases including many lipid related pathologies and a neglected tropical disease known as lymphatic filariasis. While it has been possible to study the vessel function in the context of fluid drainage and immune cell trafficking, the capability to …
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Caracterização da resposta imunometabólica frente a infecção por Leishmania amazonensis e Leishmania braziliensis em macrófagos de camundongos BALB/C
INTRODUCTION: Leishmaniasis is a neglected tropical disease caused by protozoa of the genus Leishmania and represents a serious public health problem. These parasites infect cells of the innate immune system, particularly macrophages, and possess the ability to modulate cellular metabolism during …
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Neutrophil interactions with Leishmania amastigotes: implications for chronic leishmaniasis
Leishmaniasis is a neglected tropical disease responsible for considerable morbidity and mortality in the developing world. The immune response against Leishmania parasites must be fine-tuned to promote pathogen clearance without triggering excess inflammation, and this requires the concerted …
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Characterisation of Host- Parasite- Microbiota Interactions that Drive Hatching in Trichuris Species
… the tropics and subtropics, making it a key neglected tropical disease (NTD). Infection occurs upon ingestion of whipworm eggs that hatch in the caecum and proximal colon, liberating larvae that establish in the intestinal epithelia. Trichuriasis has been studied in murine and porcine models …
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Pulmonary vascular malfunction and inflammation during Orientia tsutsugamushi infection
… Orientia tsutsugamushi. Scrub typhus remains a neglected tropical disease, despite being a tremendous burden in endemic areas. Lung injury is one of the most common pathologies that arise from severe cases of scrub typhus, but the underlying mechanisms are unclear. Development of relevant animal …
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Efficacy and Safety of Pharmacological Treatments of Chagas Disease
Background: Chagas disease is a neglected tropical disease that causes a high burden of disease in the Americas. Current trypanocidal treatments vary drastically in efficacy, depending on the stage of disease and the drugs administered. Conventional trypanocidals present a significant risk of …
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Mosquito Menace: Dengue Fever and Public Health in Singapore, 1965 – 2000
… the world’s fastest growing vector-borne disease, is often framed as a “neglected tropical disease” or an “emerging infectious disease”. But dengue is far from novel in Singapore, a tropical island-nation that has dealt with the disease for decades. This dissertation charts a previously …
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Prevalence and factors associated with Schistosoma Haematobium infection among School going Children of Katete District
Background: Schistosomiasis though considered a neglected tropical disease puts 779 million people at risk of being infected while about 200 million people are infected in the world. In Zambia 2 million people are infected putting the prevalence at 16%. The prevalence and factors associated with S. …
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Probing the biology of liver fluke-flukicide interplay
… agricultural yield in livestock animals and is a neglected tropical disease of humans. A limited portfolio of flukicide drugs are available, however treatment of the highly pathogenic acute stage is unique to the benzimidazole, triclabendazole (TCBZ). Reports of TCBZ-resistant Fasciola hepatica …
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Estudo coproparasitológico e epidemiológico do complexo teníase-cisticercose em habitantes do município de Marizópolis - Paraíba
… has worldwide distribution, and is a neglected tropical disease that constitutes a serious public health problem. Has high prevalence especially in regions where health and socioeconomic conditions are p oor, which contributes to the maintenance and transmission of the parasite cycle. …
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Repurposing quinoline-based (metallo) drug leads for the treatment of Leishmania major-induced cutaneous leishmaniasis
Leishmaniasis is a vector-borne neglected tropical disease, of which cutaneous leishmaniasis is the most common form. There is a crucial need to develop new drugs for cutaneous leishmaniasis, as current drugs are sub-optimal due to parasite-specific drug resistance, drug-induced host toxicity and …
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