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Showing 1 to 20 of 21 for “"negishi"”.
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Nickel-catalyzed asymmetric cross-couplings of secondary alkyl electrophiles and photoinduced, copper-catalyzed C-N couplings
… development of three nickel-catalyzed asymmetric Negishi cross-couplings of secondary alkyl electrophiles via a stereoconvergent process. In Section 1.1, asymmetric Negishi arylations and alkenylations of [alpha]-bromonitriles with arylzinc and alkenylzinc reagents are achieved using a …
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Part I: Mechanistic Insight in Alkyl-Alkyl and Aryl-Aryl Negishi Cross-Coupling Part II: Large Scale Synthesis of NHC Precursors: 2,6-DI(3-Pentyl) Aniline and 2,6-DI (4-Heptyl) Aniline
Part I: An efficient method for alkyl-alkyl Negishi cross-coupling reaction of unactivated primary alkyl halides with higher-order zincate species (synthesized from dialkylzinc and a non-coordinating halide salt in situ) using Pd-PEPPSI-IPent (Pyridine-Enhanced Pre-catalyst Preparation …
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New reactivity and selectivity in transition metal-catalyzed C-C and C-N bond forming processes
… Palladium-Catalyzed Completely Linear-Selective Negishi Coupling of 3,3-Disubstituted Organozinc Reagents with Aryl and Vinyl Electrophiles A palladium-catalyzed general and completely linear-selective Negishi coupling of 3,3- disubstituted allyl organozinc reagents with (hetero)aryl and vinyl …
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New applications of heteroarylzinc nucleophiles
… Air-Stable 2-Pyridylzine Reagent and its Use in Negishi Cross-Coupling Reactions. As an alternative to unstable or unreliable 2-pyridylboron reagents, a solid, air-stable 2- pyridylzinc reagent was developed. Using 1,4-dioxane as an additive enabled a 2-pyridylzinc concentrate as a free-flowing …
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Progress in nucleophilic catalysis and development of nickel-catalyzed cross-couplings of propargylic halides
… the development of the first asymmetric Negishi reaction of arylzinc reagents with secondary electrophiles.
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Development of Cobalt and Nickel N-Heterocyclic Carbene Complexes for Cross-Coupling Reactions
… Pd counterparts would improve reactivity in Negishi, Suzuki-Miyaura, and Buchwald-Hartwig amination cross-coupling reactions. Co(IPent)Cl2(Pyr), Co(IPentCl)Cl2(Pyr), and Co2IPr2(OAc)4 were prepared, identified by X-ray crystallography, and evaluated in preliminary Negishi cross-coupling …
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SYNTHESES AND METAL MEDIATED REACTION CHEMISTRY OF 2-SILYL-1,3-DIENES
… reactions and subsequent Hiyama-Denmark and Negishi cross couplings to make highly substituted cyclohexenoids with controlled relative and absolute stereochemistries. Diterpenoids containing the clerodane carbon skeleton are prevalent as secondary metabolites. Synthetic approaches to the …
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Cross-coupling reactions of unactivated alkyl halides
… palladium-based catalyst that is effective for Negishi couplings of primary alkyl electrophiles. A single protocol (2%Pd₂(dba)₃/8%P(Cyp)₃/NMI in THF/NMP at 80⁰C) can be applied to a broad spectrum of electrophiles, including chlorides, bromides, iodides, and tosylates. Concerning the scope of …
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Nickel-catalyzed asymmetric arylations of [alpha]-halocarbonyl compounds and studies of boratabenzene-containing transition metal complexes
… 1 describes the development of an asymmetric Negishi arylation of a-bromoketones using a nickel/pybox catalyst. The third section details the development of a Suzuki arylation of a-bromo- and a-chloroamides using aryl-(9-BBN) reagents. Both of these cross-coupling procedures are …
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A novel route to fluoroarenes from trifluoroethanol
… at near ambient temperature and underwent Negishi coupling with a range of aryl-halides. A co-solvent (N,N-dimethylpropylene urea) was necessary to generate 2,2-difluoro-1-(2'-methoxy-ethoxymethoxy)-1-zinc chloride in good yield. The zinc coupling partners were also converted to …
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A study of human resource development strategies for how to effectively develop middle managers at global conglomerates to create cross-business collaboration
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-04-12 without embargo terms
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A Stereospecific Pd-Catalyzed Suzuki Cross-Coupling Reaction and a Statistical Study of the Ligand's Role in Stereoselection
… cross-coupling reactions, which include Kumada, Negishi, and Stille reactions, the Suzuki cross-coupling reaction exhibits particularly wide functional group compatibility, while employing non-toxic, air-stable organoboron nucleophiles. Conventional studies of Pd-catalyzed Suzuki cross-coupling …
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CATALYTIC BORYLATION OF C-H BONDS: A ROUTE TO PHOTOPHYSICALLY INTERESTING PYRENE DERIVATIVES
… Sonogashira, Buchwald-Hartwig and Negishi cross-coupling reactions. Using this methodology, a library of 2- and 2,7-substituted pyrenes bearing donor and acceptor groups, including aryl, ethynyl, arylethynyl, alkyl, hydroxy, alkoxy, diarylamino, carboxylic acid and diarylboryl …
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Mg- and Zn-Mediated Synthesis of Heterocycles in Solution and on the Solid Phase
… 4, readily available in four steps from uracil. Negishi cross-coupling reactions were then performed using zinc reagent 2 and various aryl iodides. N N O O Bn Bn 4 Br HN N H O O N N O O Bn Bn 2 ZnBr Ar - I Pd(dba)2 (2.5 mol %) N N O O tfp (5 mol %) THF, 25 °C, 12 h Bn Bn Ar 3a-j: 62-95 % THF, 0 …
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Nickel-catalyzed cross-coupling reactions involving secondary and tertiary alkyl nucleophiles
… chapter, the first general nickel-catalyzed Negishi reaction for the cross-coupling of unactivated, acyclic secondary alkylzinc halides and aryl and hetero-aryl iodides has been reported. This process is the first to overcome the β-hydride elimination problem inherent to the use of the …
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Total synthesis of (±)-cis-trikentrin B, (±)-herbindole A and (±)-herbindole B. investigation into the regioselectivity of 6,7-Indole aryne cycloadditions
… via the Fujimoto protocol and subjected to Negishi cross-coupling with dimethyl zinc and diethyl zinc to complete the synthesis of (±)-herbindole A and (±)- herbindole B respectively. Our group has previously shown that 3-phenyl-6,7-indole aryne undergoes regioselective cycloaddition with …
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Activation of diboron reagents: The development of mild conditions for the synthesis of unique organoboron compounds
… along with Professors Richard Heck and Ei-ichi Negishi, in 2010 for their important contributions in palladium-catalyzed cross-coupling chemistry. Over the last 30 years, reports on organoboron compounds have increased exponentially. This dissertation describes the author's contributions to the …
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Novel Polycyclic Benzannulated Indole Scaffolds via Indole Aryne Cycloaddition, Pd (0)-Catalyzed Cross-coupling and ROM/RCM methodologies: Their Applications to Library Development and Drug Discovery
… including but not limited to Suzuki-Miyaura, Negishi and Buchwald-Hartwig. Diversity of these scaffolds can be further enhanced via olefin functionalization: cross metathesis, hydroamination and epoxidation among others to afford pharmaceutically useful functional groups like carbamates, …
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Recent Advances in Indole Aryne Cycloaddition Chemistry. Part I: Total Synthesis of (±)-cis-Trikentrin B. Part II: Investigation into the Regioselectivity of 6,7-Indole Aryne Cycloadditions. Part III: Synthesis and Reactions of Novel Tribromoindoles
… 4,5-benzannulated scaffolds were subjected to Negishi cross-coupling with dimethyl and diethylzinc to demonstrate the proof-of-concept for library development.
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Synthesis of a Conjugated Ladder Polymer for Application in Direct Writing.
Since the discovery of electroluminescence in conjugated polymers in 1990, electro-optic devices such as light emitting diodes, flat panel all polymer displays, and lasers have received a great deal of attention. Greater conjugation in these pi-electron systems leads to enhanced fluorescence and …
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