Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 93 for “"negative regulation"”.
-
Negative Regulation der Oncostatin M-vermittelten Signaltransduktion
… factors to induce the feedback inhibitor. The negative regulatory role on OSM mediated signal transduction is independent of the gp130 Y759 motif. However, a direct interaction of SOCS3 with the OSMR – analogous to gp130 and all receptors so far described to be SOCS3 sensitive – could be …
-
Negative Regulation of the accBC Operon in Escherichia Coli
… E. coli AccB activity, but did not cause negative regulation of the accBC genes. A chimeric protein consisting of the amino-terminal 44 amino acids of E. coli AccB fused to the carboxyl-terminal biotinylation domain of B. subtilis AccB complemented AccB activity and caused negative …
-
Negative regulation of gene expression by the tumor suppressor p53
… facilitate downstream repression. Indirect regulation of gene repression by p53 often involves induction of intermediary factors that fall into several categories: proteins (e.g. p21), microRNAs (e.g. miR-34a), and lincRNAs (lincRNA-p21). This dissertation discusses multiple aspects of …
-
Streptococcus pneumoniae mediated negative regulation of CD8+ T cell effector function
Infection with influenza A virus (IAV) can lead to increased susceptibility to subsequent bacterial infection, often with Streptococcus pneumoniae (Spn). Clinical and experimental data indicate increased disease severity when a coinfecting agent is present during IAV infection, indicating the need …
-
Negative Regulation of the Hippo Pathway by the Ajuba LIM Proteins
… Hippo kinase cascade is critical for both regulation of organ size in development and tumor suppression. Several mechanisms, such as cell-cell contact in vitro and organ size in vivo, have been implicated in the activation of the Hippo pathway, leading to inactivation of the YAP/TAZ …
-
Negative Regulation of Inflammation: Implications for Inflammatory Bowel Disease and Colitis Associated Cancer
… signaling. As with any signaling cascade, strict regulation is required for proper functioning, as abnormalities within the pathway are often associated with pathologic outcomes. A hyperactive inflammatory response within the gastrointestinal tract, for example, contributes to inflammatory bowel …
-
Ubiquitination of EpoR and p85 in Ligand Induced EpoR Down-Regulation
… blood cells EpoR signaling is also subject to negative regulation. Mutations in EpoR or JAK2 that abrogate negative regulation cause erythrocytosis in hematological malignancies. Primary familial and congenital polycythemia (PFCP) is a proliferative disorder characterized by erythrocytosis and …
-
Regulation of Syk activity in GPVI-mediated platelet activation
… role in this physiological process suggests regulation of its activity is required to maintain the platelets response to collagen within physiological limits. The regulation of Syk activation is the focus of this work. Previously published reports implicate the phosphatases SHP-1, SHP-2 and …
-
The Novel Role of Interleukin-1 Receptor-Associated Kinase 1 in the Signaling Process Controlling Innate Immunity and Inflammation
… we demonstrated that IRAK-1 is involved with the negative regulation of PI3K-Akt dependent signaling pathway induced by insulin and TLR 2&4 agonists. Out data also indicate that IRAK-1 can interact with IRS-1 protein both in vivo and in vitro. The binding sites for the IRAK1-IRS1 biochemical …
-
Studies on the operator-repressor-effector interactions in the glp regulon of Escherichia Coli K-12
… the glp genes of Escherichia coli are subject to negative regulation by the glpR-encoded repressor (GlpR). Comparison of the repressor binding affinity for consensus and altered consensus operator regions showed that positions 3, 4, 5, 7 and 8 bp removed from the center of operator symmetry are …
-
The role of signal regulatory protein alpha in regulating macrophage subset activity in homeostasis and inflammation
… as a “don’t eat me” signal, SIRPα-CD47 ligation negatively regulates Mφ phagocytic activity. This study developed a co-culture system between CD47+ HL-60 and K562 cells, and SIRPα+ Mφ subsets in order to investigate whether the regulatory effect of SIRPα-CD47 ligation extends to negative …
-
Regulation of inflammatory TLR signalling by the BCAP adaptor
… signalling. In TLR signalling, BCAP acts as a negative regulator of inflammatory signalling. Regulation of TLR signalling is essential as overstimulation can cause excessive and pathological inflammation, which leads to serious illnesses such as sepsis and rheumatoid arthritis. Through an …
-
Regulation of DNA (Cytosine-5) Methyltransferase 1 in the cell cycle and its role(s) in doxorubicin-mediated micronuclei formation
… DNMT1, emerged as an important mediator for the negative regulation of DNMT1 by p21WAF1. Aside from elucidating the mechanism involved in regulating DNMT1, the involvement of DNMT1 in DNA damage response was studied. Doxorubicin can induce the formation of extranuclear bodies during mitosis …
-
Das Tyrosin 759 des Signaltransduktors gp130 in der IL-6-abhängigen Proliferation von Prä-B-Zellen
… stimulation. Furthermore SHP2 is involved in negative regulation of the signal transduction through the Jak/STAT pathway. Negative regulation of IL-6 signal transduction through SHP2 and SOCS3 requires the tyrosine 759 of gp130. Interleukin-6 induces B-cell proliferation. There have been …
-
Study of Rest As A Negative Regulator of P16Ink4A
<p><strong>STUDY OF REST AS A NEGATIVE REGULATOR OF P16<sup>INK4A</sup></strong><strong> </strong></p> <p><strong>Monica Gireud, B.S.</strong></p> <p><strong>Thesis Advisor: Vidya Gopalakrishnan, Ph.D.</strong></p> <p>The<em> RE1</em> Silencing Transcription Factor (REST) is a negative regulator of …
-
Regulation of receptor kinase-mediated immune signalling by dynamic phosphorylation
… to be tightly regulated. How PTI signalling is negatively regulated in plants is not fully understood. PRRs are present at the plasma membrane in dynamic kinase complexes that heavily rely on trans-phosphorylation to initiate signaling. The Arabidopsis cytoplasmic kinase BIK1 associates with …
-
Regulation of Weibel-Palade Body Exocytosis by alpha-Synuclein in Endothelial Cells
… a-synuclein. Results also showed that the negative regulation of WPB exocytosis required the N-terminus or NAC region of a-synuclein, but not C-terminal acidic tail, and that a-synuclein affected WPB exocytosis through interference with RalA activation by enhancing the interaction of …
-
Profiling Emotion Regulation: Exploring patterns of regulation in classroom behaviour
Emotion Regulation describes the ability to influence the experience and expression of affect. Adaptive emotion regulation contributes to healthy development, social competence and academic success (Kochanska, Murray & Harlan, 2000). This study investigated the behavioural strategies for emotion …
-
Characterization of theWound-Induced Signaling Pathway In Tomato
… not expressed in protoplasts. I have shown that negative regulation of MKK4 via conventional protein degradation mechanisms is not responsible for the lack of expression in the protoplast system.</p>
-
Phenotypic variation and bistability within flagellar gene network in Salmonella Typhimurium
… Thus, FliZ and YdiV, in poor media, form a negative regulation loop which results in a bistable motility pheotype. However, the extent of bistability is unclear. This study aims to characterize the extent of bistability within the flagellar network in Salmonella enterica serovar Typhimurium. …
Page 1 of 5