Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 48 for “"negative feedback loop"”.
-
Dynamic Characterization of the IKK:κBα:NFκB Negative Feedback Loop Using Real-Time Bioluminescence Imaging
… canonical NF-κB signaling is the IKK:NF-κB: IκBα negative feedback loop that plays a major role in regulating the strength and duration of NF-κB transcriptional activity. We have developed and characterized an unique bioluminescent reporter (κB<sub>5</sub><sub>à</sub>IκBα-FLuc) that recapitulates …
-
Sensitivity analysis of oscillating dynamical systems with applications to the mammalian circadian clock
… architectures, with one having an additional negative feedback loop compared to the other. The differences in their behavior with respect to phases, the period and amplitude are discussed in the context of their network architecture. It is found that, contrary to previous assumptions in the …
-
Using Stable Limit Cycles to Model p53-Mdm2 Protein Interactions in the Presence of DNA Damage
… within a cell. Another protein, Mdm2, is a negative regulator of p53. In the presence of DNA damage, Mdm2 does not bind to p53, thus activating the p53 protein. This activation then promotes the mechanisms necessary to either fix or terminate the damaged cell. The concentration of both p53 …
-
Mitigating the effects of ribosome limitations on synthetic circuits via high-gain sRNA-mediated negative feedback
… of resource limitations by adding a high-gain negative feedback loop to one of the circuits. The loop includes an sRNA construct. We explore different implementations of this circuit and model them mechanistically. Furthermore, we begin physically implementing one of the circuit designs by …
-
A ROLE OF PRL-3 IN AUTOPHAGY AND ITS REGULATION IN HUMAN CANCERS
… ITSELF IS ALSO DEGRADED BY AUTOPHAGY, FORMING A NEGATIVE FEEDBACK LOOP WITH AUTOPHAGY. CLINICALLY, PRL-3 IS DEPENDENT ON AUTOPHAGY ACTIVITY IN PROMOTING OVARIAN CANCER PROGRESSION. IN ADDITION, I SHOWED THAT CONSTITUTIVELY ACTIVATED MUTATION OF KRAS, WHICH IS ESSENTIAL IN THE DEVELOPMENT OF MANY …
-
Mathematical Modeling of Circadian Gene Expression in Mammalian Cells
… In the first project, we modified the core negative feedback loop in a mathematical model of the mammalian genetic oscillator so that the unrealistic tight binding between the repressor PER and the activator BMAL1 is relaxed for robust oscillations. By studying the modified extended models, …
-
Expanding Antigen-specific Tr1 Cells to Treat Autoimmunity
… re-myelination. Thus this therapy provides a negative feedback loop that serves to counter autoimmune disease progression.
-
Problematic Alcohol Use and Marital Adjustment: An Interdependence Theory Perspective
… problems often exacerbate each other, creating a negative feedback loop. The current project examined problematic drinking and marital adjustment using an interdependence theory framework over three timepoints. Married couples (N = 123 dyads) completed a web-based baseline assessment and two …
-
A Neuroprotective Role for Mir-1017, a Non-Canonical Mirna
… pattern; furthermore we witnessed a disrupted feedback loop in the miR-1017 null background resulting in higher Da2 transcriptional activation. This could be phenocopied with the acetylcholine receptor (AchR) activity antagonist, Donepezil, which likewise resulted in higher GFP expression. …
-
Design of a clock and data recovery circuit in 65 nm technology
… consists of a phase detector, a charge pump, a loop filter and a voltage-controlled oscillator. This thesis includes an overview of all the building blocks of a PLL-based CDR, derivation of the mathematical formulations of the negative feedback loop, and a report on closed loop behavioral …
-
Aspirations, drought, and the perception of weather: How are future goals affected by severe rainfall shocks?
… targets may sustain conditions of poverty in a negative feedback loop. Despite the connections to productive behavior, factors that may contribute to or work against the formation of aspirations have seldom been identified outside of the experimental setting. Particularly, we seek to understand …
-
Demand bubbles and phantom orders in supply chains
… response in two important ways. First, a negative feedback loop of lost sales captures the effect that an initial increase (decrease) in demand leads to a decrease (increase) in the manufacturer's service level, causing customer demand to decrease (increase). Second, a positive feedback …
-
Mathematical Modeling of Circadian Rhythms in Drosophila melanogaster
… is that the 24-hour period arises from a negative feedback loop controlling the transcription of clock genes. However, a better understanding of this mechanism requires an approach that integrates both mathematical and molecular biology. From the recent discoveries in molecular biology and …
-
Microrna-200 Regulates Ecm-Dependent Β1-Integrin/Fak Signaling and Cancer Cell Invasion
… transition, partially through its double-negative feedback loop with the transcriptional repressor Zeb1, yet the mechanisms on how miR-200 controls the invasive phenotype are not fully understood. Recent studies have shown that the miR-200/Zeb1 axis regulates cell-cell and cell-matrix …
-
Frequency and phase locking of a CW magnetron : with a digital phase locked loop using pushing characteristics
… synthesizer IC (Analog Devices ADF4113) in a negative feedback loop, with this method we exploit the use of the pushing mechanism where the ADF41113 controls the power supply output to vary the magnetron’s anode current, keeping its natural frequency locked to the reference. We next …
-
Tumor Suppressor APC and Musashi1: Double-Negative Feedback, Wnt Signaling and Colon Cancer
… epithelium. I have identified a double-negative feedback loop between APC and a sequence specific RNA binding protein, Mushashi-1 (MSI1). I hypothesize that this feedback loop serves to maintain a critical balance and that disruption of this balance leads to loss of homeostasis and …
-
Prostanoid-mediated Inhibition of IL-6 Trans-Signalling in Pulmonary Arterial Hypertension: a Role for Suppressor of Cytokine Signalling 3?
… JAK/STAT is inhibited is via SOCS3 in a type of negative feedback loop whereby IL-6 induces transcription of SOCS3, which then attenuates further JAK/STAT signalling. SOCS3 can also be induced by cAMP. This is interesting as prostanoids, a type of drug used in the treatment of PAH due to its …
-
Insights into the regulation of mTOR signaling and the consequences of pharmacological inhibition
… can suppress insulin signaling, establishing a negative feedback loop to PI3K. Consistent with its role in cell growth, derangements in mTOR signaling are increasingly associated with cancer and, more surprisingly, metabolic diseases. In the work described here, we have investigated the …
-
The Role of Cyp33 in MLL Mediated Gene Repression
… (CYP33) has previously been shown to be a negative modulator of MLL gene transactivation activity (Fair, K 2001, Anderson, M 2002). It has been well established that for CYP33 to exert its repressive effects on MLL several events must occur. CYP33 binds to the 3rd PHD (PHD3) finger of MLL …
-
Induction kinetics of the PhoQ-PhoP two-component system in Escherichia coli
… that this impulse response is caused by a negative feedback loop in which active PhoP transcribes mgrB, a gene encoding a small membrane protein that interacts directly with PhoQ to repress the output of the system. MgrB selectively inhibits the ability of PhoQ to phosphorylate PhoP, and …
Page 1 of 3