Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"negative cooperativity"”.
-
Agonist-Induced Conformational Changes In The Nmda Receptor
… fully understood, including the phenomenon of negative cooperativity between the glycine- and glutamate-binding sites of the receptor and the mechanism controlling partial agonism. Past studies utilizing static structural snapshots of the receptor or isolated domains of the receptor have …
-
Studies of the NAD metabolism of Haemophilus influenzae
… and functioned in a manner indicative of negative cooperativity with all substrates except several modified in the adenine ring. The most effective inducer of negative cooperativity was NAD as indicated by its Hill coefficient of 0.26. The enzyme was inhibited by adenine nucleotides _ and …
-
Allostery and GroEL: Exploring the Tenets of Nested Cooperativity
… cycle and offers a refined model for nested cooperativity that successfully accounts for the effects of these ligands. Initial studies take advantage of a single ring variant, termed SR1, to examine the allosteric properties of GroEL in the absence of complicating interactions arising from …
-
Cooperativity of ligand binding as a function of monomer-dimer equilibrium Parameters and Acceptor Concentration
… involving ligand interactions is presented. Cooperativity features of specific limited models are analyzed by selecting the appropriate family of equilibrium constants from this general scheme. Each system is then characterized in terms of Hill coefficient dependency on alterations in values …
-
Modulation of The Receptor Gating Mechanism and Allosteric Communication In Ionotropic Glutamate Receptors
… pathway regarding the mechanism underlying negative cooperativity and how mutation in the receptor leads to abnormal functional behavior. These findings will allow us to understand the conformational control regarding modulation of receptor function and will serve as a basis for developing …
-
Unraveling the interactions between MBNL1 protein and its RNA targets
… association. A multiple mode binding model with negative cooperativity has been proposed based on the kinetic data obtained.
-
Studies of multicomponent assemblies
… to explore the properties of the dendrimers. The cooperativity of the system was measured, and primarily negative cooperativity determined by the entropic contributions was uncovered. As the dendrimers increased in size, the thermodynamic origins of binding were determined to a greater extent by …
-
Energetic and dynamic characterization of the IgA1:FcαRI interaction reveals long-range conformational changes in IgA1 upon receptor binding
… molecule. This is consistent with the apparent negative cooperativity we observed in our biosensor analyses with immobilized Fcα, where the second FcαRI binding event exhibited a weaker affinity than the first binding event. To experimentally validate the computational analyses and investigate …
-
The inhibition of M-MLV and HIV-1 reverse transcriptase by polyphenols extracted from the resurrection plant Myrothamnus flabellifolia (Welw.)
… at high dTTP concentration, suggesting zero and negative cooperativity respectively. The final part of this thesis tested the inhibitory effect of pure and crude polyphenol fractions on the activity of M-MLV and HIV-1 RTs. Results showed that all polyphenol fractions inhibited M-ML V and HIV -I …