Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"necrostatin-1"”.
-
Novel Protective Agents against Cerebral Ischemia/Reperfusion Injury.
… novel agents Gly<sup>14</sup> humanin (HNG) and necrostatin-1 (Nec-1) were examined. HNG, a highly potent neuropeptide against amyloid toxicity, exhibited anti-apoptotic properties on cerebral ischemia injury. HNG reduced infarct volume after ischemia/reperfusion injury with pre-treatment or …
-
Mitochondrial Dynamics: Exploring A Novel Target Against Myocardial Ischemia-Reperfusion Injury
… was in part rescued by co-administration of Necrostatin-1, suggesting that necroptosis (programmed necrosis) may play a role in this phenomenon. </p> <p>In conclusion, our results show that DRP1 translocation to mitochondria plays a mechanistic role in mediating cardiomyocyte injury in the …
-
Exploiting tumour cell dependency on pro-survival BCL2 proteins with BH3 mimetics
… which was reversed by inhibition of RIPK1 by necrostatin-1. BCL-XL may directly inhibit necroptosis induction at the level of the necrosome through the binding of the effector protein MLKL, which was displaced upon BCL-XL inhibition. BH3 mimetics are effective as single agents for the …
-
Identifying novel drugs for the treatment of rhabdomyosarcoma
… and p-MLKL and inhibition of necroptosis with necrostatin-1 with a corresponding significant increase in cell viability suggests that AJ-5 is also capable of triggering a form of programmed necrosis. Furthermore, AJ-5 reduced autophagic flux as shown by reduced LC3II accumulation in the …