Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"ncRNA"”.
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ncRNA come biomarcatori e regolatori molecolari del cancro alla prostata
… eucarioti superiori e gli RNA non codificanti (ncRNA) che hanno una funzione regolatoria. Gli RNA, specialmente gli ncRNA, sono attori cruciali nella regolazione dei meccanismi cellulari grazie alla loro capacità di interagire e regolare altre molecole. È interessante notare che malattie …
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Regulation of the Kcnq1ot1 Imprinting Domain in Mouse
… an imprinting control region (ICR), the Kcnq1ot1 ncRNA, and maternally expressed protein-coding genes. Truncation of the Kcnq1ot1 ncRNA or deletion of the Kcnq1ot1 ICR, including the Kcnq1ot1 ncRNA promoter results in biallelic expression of normally paternally silent protein-coding genes in …
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RNA localizations of proteins that interact with the chromosome passenger complex
… biology, but how mitosis affects these nuclear ncRNA transcripts is less well understood. This study examined the behavior of several ncRNAs through mitosis. It is understood that Aurora B Kinase, or AURKB, plays a role in the dispersal of the ncRNA Xist from chromatin in mitosis, but our …
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Detection of non-coding RNA with comparative genomics and the sequential closure of smooth graphs in Cartesian currents
… algorithms for identifying non-coding RNA (ncRNA) genes. It describes a rapid and highly reliable comparative statistical method for identification of functionally significant base pairs in ncRNA genes in multiple sequence alignments of cross-species homologs, a divide-and-conquer approach …
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Genome wide search for pseudo knotted non-coding RNAs
Non-coding RNAs (ncRNAs) are the functional RNA molecules that are involved in many biological processes including gene regulation, chromosome replication and RNA modification. Searching genomes using computational methods has become an important asset for prediction and annotation of ncRNAs. To …
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Transcript Regulation within the Kcnq1 Domain
… of a paternally expressed long noncoding RNA (ncRNA) Kcnq1ot1. The Kcnq1ot1 ncRNA is expressed on the paternal chromosome due to a differentially methylation region located within its promoter. The promoter is methylated on the maternal allele thus inhibiting ncRNA expression, whereas the …
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Use of Comparative Genomics for Non-coding Rna Prediction and Investigation of Dna Introgression in Yeast
… thermodynamic methods to predict non-coding RNA (ncRNA) in Saccharomyces cerevisiae. Sets of positive and negative control genes were evaluated to determine the effect of window sizes and step sizes on the sensitivity of ncRNA identification. The approach was then applied to predict ncRNA genes on …
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The Role of an Ultraconserved Long Non-coding Rna in B-Cell Lymphomagenesis
… into mono-exonic long non-coding RNAs (lncRNAs) known as transcribed ultraconserved regions (T-UCRs). These regions, despite lacking protein-coding potential, are increasingly recognized for their regulatory roles in gene expression, including the modulation of non-coding RNA (ncRNA) …
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Non-Coding Genomics of Methanocaldococcus Jannaschii: A Survey of Promoters, Non-Coding RNA Genes, and Repetitive DNA Elements
… non-coding RNA genes. Nonprotein-coding RNA (ncRNA) promoters share the same set of core elements but with more deviations from the consensus compared to those of tRNA genes; in accordance, they possess lower affinity to the transcription factors. Some additional ncRNA transcripts were …
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In silico prediction of non-coding RNAs using supervised learning and feature ranking methods
… for development of a non-coding RNA (ncRNA) classification model based on features derived from folding the consensus sequence of multiple sequence alignments using different folding programs: RNAalifold, CentroidFold, and RSpredict. The method ranks these folding features according to …
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snoDB: An interconnected online database of human snoRNA
… vast underexplored landscape of non-coding RNAs (ncRNA). These RNAs have been slowly uncovered since the 1960s but it took until the turn of the century, and the advent of high-throughput RNA-Sequencing methodologies, for us to finally see how dominated by ncRNAs the transcriptome really is. …
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Big data analytics in computational biology and bioinformatics
… that the secondary structure in non-coding RNA (ncRNA) is more conserved during evolution than its primary nucleotide sequence. Using a covariance model approach, the stems and loops of an ncRNA secondary structure are represented as a statistical image against which an entire genome can be …
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Predicting molecular markers of development and regeneration through integrative analysis of high-throughput genomics data
… non-coding RNA markers in a muscle system, a ncRNA prediction approach enabling the detection of longer ncRNAs was used to identify miRNA containing sites in the mouse genome. The use of EST data was determined to improve ncRNA prediction strategies during the development of this method by …
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Negative regulation of gene expression by the tumor suppressor p53
… (e.g. p21), microRNAs (e.g. miR-34a), and lincRNAs (lincRNA-p21). This dissertation discusses multiple aspects of p53-dependent gene repression and presents novel targets of p53-mediated regulation. Specifically, we have found that p53 down-regulates the transcription of the oncogenic …
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Discovery and Validation of New Regulatory RNA Elements in Chlamydia trachomatis
… of a newly defined family of non-coding RNAs (ncRNAs) that are differentially expressed during the developmental cycle and the induction of persistence and reactivation (Using IFNγ and Carbenicillin). Non-coding RNAs were initially identified using an intergenic tiling microarray and were …
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Structure-based realignment of non-coding RNAs in multiple whole genome alignments
… is the de novo prediction of non-coding RNAs (ncRNAs) from structural conservation visible in the alignment. However, current methods for constructing genome alignments do so by explicitly optimizing for sequence similarity but not structural similarity. Therefore, de novo prediction of ncRNAs …
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FUNCTIONAL STUDY OF THE NONCODING REGULOME OF THE NUCLEAR FACTOR Y IN HUMAN CANCER
Introduzione. Gli RNA non codificanti (ncRNA) sono implicati nella regolazione di diversi processi biologici, la cui espressione e funzione alterata sono associate a processi di tumorigenesi. In questo lavoro, ci siamo concentrati sugli RNA antisenso (asRNA), che svolgono un ruolo critico nella …
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Non-coding RNA networks regulating leaf vegetative desiccation tolerance in the resurrection plant Xerophyta humilis.
… to the role of regulatory noncoding RNAs (ncRNAs). To investigate the presence and roles of possible ncRNA players, RNA-Seq was performed on desiccating Xerophyta humilis leaves and a bioinformatic pipeline assembled to identify the potential decoy lncRNAs and miRNAs present. Interaction …
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INVESTIGATING THE BASES OF THE SPECIFICITY OF THE RESTRICTOR COMPLEX FOR THE TERMINATION OF NONCODING TRANSCRIPTION
… transcription of thousands of noncoding RNAs (ncRNA) in mammalian genomes. The mechanism of Restrictor-mediated termination is not known but does not involve cleavage of the nascent RNA, setting it apart from known mammalian termination machineries. Furthermore, it is uniquely specific for …
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