Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"navitoclax"”.
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The Development of Peroxide-Responsive Arylboronic Acids for Antibody-Drug Conjugates and Small-Molecule Prodrugs
… Non-targeted drugs, such as olaparib and navitoclax, often suffer from poor tolerability and toxicity because they exert their function on healthy cells as well as target cancer cells. Thus, to improve their efficacy and safety profile, inactive prodrugs of olaparib and navitoclax were …
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Cellular Senescence in Non-Small Cell Lung Cancer: from mechanisms to therapeutic opportunities
… the galacto-conjugation of senolytic ABT-263 (navitoclax) in the form of an activatable pro-drug significantly enhances cytotoxicity in combination with cisplatin, resulting in reduced lung cancer tumour growth. Importantly, our approach demonstrates decreased navitoclax-associated toxicities, …
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Premature vascular senescence during diabetic retinopathy
… approach for elimination of senescent HRMECs. Navitoclax was found to be an effective senolytic for HRMECs<i> in vitro</i>.
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Función de la telomerasa en envejecimiento y rejuvenecimiento. Búsqueda de compuestos bioactivos que regulen su actividad.
… ligando (mapeo farmacóforo) al resveratrol y al navitoclax como moléculas diana. Las técnicas de VS revelaron una lista de polifenoles y compuestos senolíticos que se probaron en modelos de pez cebra de envejecimiento prematuro. Los resultados obtenidos permitieron identificar una novedosa e …
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Regulation of p21 Function by a Sense Long Non-Coding RNA Generated by Alternative Polyadenylation
… depletion in combination with the senolytic drug navitoclax significantly reduces the number of surviving senescent cancer cells, suggesting that <em>SPUD</em> depletion in combination with DNA damaging/senolytic therapy might be a potential approach to mitigate the effects of surviving …
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Bim Mediates Imatinib-Induced Apoptosis of Gastrointestinal Stromal Tumors: Translational Implications
<p>Gastrointestinal stromal tumors (GISTs) are oncogene-addicted cancers driven by activating mutations in the genes encoding receptor tyrosine kinases KIT and PDGFR-α. Imatinib mesylate, a specific inhibitor of KIT and PDGFR-α signaling, delays progression of GIST, but is incapable of achieving …