Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"natural reward"”.
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The Role of CREB in Social Isolation and Natural Reward Behavior
… behaviors such as learning and memory, drug reward and depression. The work presented in this dissertation examines the role of CREB in an inactive stress paradigm, social isolation. Social isolation is a model which decreases CREB-mediated transcription in the nucleus accumbens and results …
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Shuttlebox Self-Stimulation Behavior Following Intracerebral Microinjections of Morphine Into the Ventral Tegmental-Substantia.
… that these effects reflect a sensitization of natural reward pathways by the opioids. Previous work has identified the ventral tegmental-substantia nigral area (VT-SN) area to be quite sensitive to morphine's facilitative effects on intracranial self-stimulation (ICSS). The present study …
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A Comparison of the Manipulations of Dopaminergic, Opioidergic or Serotonergic Systems within the Nucleus Acccumbens on the Cue-Evoked Relapse to Food-Seeking
Conditioned stimuli (CSs) associated with reward object availability are known to reinstate reward-seeking behaviors after periods of suppressed responding for a reward. Previous research indicates that the nucleus accumbens (NAcc) is a critical brain region involved in the relapse to drug-seeking …
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The Relationship between Self-Leadership and Personality: A Comparison of Hierarchical Factor Structures
… dimensions of behavior-focused strategies, natural reward strategies, and constructive thought strategies, and the personality dimensions of extraversion, emotional stability, and conscientiousness. The results of the study provide evidence that the self-leadership dimensions are distinct …
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Investigation of Glutamatergic Circuitry Underlying Copulatory Reward in Female Syrian Hamsters
… behavior in female mammals is known to involve rewarding consequences that increase the motivation to copulate. I have utilized female hamsters as a model to examine the underlying circuitry and mechanisms of this natural reward. Despite a wealth of information detailing dopaminergic …
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Nicotine Alters Gene Regulatory Networks in Dopaminergic Neurons in the Ventral Tegmental Area
… in many brain regions implicated in the reward pathway. Dopaminergic (DA) neurons originating from the ventral tegmental area (VTA) of the brain are activated by nicotine and form the natural reward pathway that is known to contribute to addiction. In recent years, microRNAs (miRNAs) have …
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KETAMINE EXPOSURE DURING ADOLESCENCE INCREASES SENSITIVITY TO REWARD-RELATED STIMULI IN ADULTHOOD
… of glutamatergic innervation within the reward circuit. We first demonstrate that juvenile ketamine treatment enhances preference for natural reward (i.e., 1% sucrose) three weeks post ketamine administration. In order to determine whether these long lasting increases in reward …
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Nucleus accumbens GABAA receptor-mediated inhibitory transmission: Relevance to early life stress and addiction
… and is an essential integration site within the natural reward-pathway, which is ‘hijacked’ by drugs of abuse. We have previously shown for accumbal medium spiny neurons (MSNs) that α2-subunit containing GABAA receptors (α2-GABAARs), mediate phasic inhibition and that their genetic inactivation …
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Neural Mechanisms of Homeostatic Need and Reward
… we examined nucleus accumbens (NAc), a canonical reward center that regulates feeding and drinking, but it is not known whether these behaviors are mediated by same or different neurons. We employed two-photon calcium imaging in awake, behaving mice and found that during the appetitive phase, both …