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Showing 1 to 20 of 746 for “"natural products"”.
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Synthesis of furanosesquiterpenoid natural products
… has been employed in the synthesis of the naturally occurring furanosesquiterpene Pallescensin-E. The structure of this compound has been confirmed by comparison of its spectral data with that of the synthesised isomer, 4,l0-dihydro-7,8-dimethyl 10H-benzof4,5Jcycloheptafl,2-bJ …
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Total synthesis of pyranonaphthoquinone natural products
<p>Pyranonaphthoquinones are a class of naturally occurring antibiotics which have in common a synthetically interesting isochromanquinone skeleton. Members of this family exhibit a variety of biological activities. Examples are frenolicin B, an anticoccidial agent; kalafungin, an antifungal agent; …
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Cascade Approaches to Polycyclic Natural Products
… syntheses of molecules in two different areas of natural products chemistry: the polyphenolic compounds dalesconols A and B and the coccinellid alkaloids psylloborine A, isopsylloborine A, and related monomeric structures. While polyphenols and alkaloids generally have little in common, the …
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Total synthesis of oxaphenalenone natural products
Oxaphenalenone (OP) natural products are a diverse class of biologically active and structurally interesting molecules most commonly isolated from fungi. Despite their important biological properties and fascinating structures, these molecules have eluded thorough synthetic studies for over fifty …
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Biosynthetic engineering of plantazolicin natural products
… and post-translationally modified peptide (RiPP) natural product that exhibits extraordinarily narrow-spectrum antibacterial activity towards the causative agent of anthrax, Bacillus anthracis. During PZN biosynthesis, a cyclodehydratase catalyzes cyclization of cysteine, serine, and threonine …
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Synthetic Studies of the Rubellin Natural Products
… manuscript includes a review of relevant recent natural product syntheses, our studies on the rubellin class of natural products, and our investigation of a rearrangement reaction of reactive iodonium ylide intermediates. First described are select syntheses of complex anthraquinone monomers and …
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Insecticidal Natural Products From Sri Lankan Plants
This thesis describes investigations of the insecticidal compounds of three Sri Lankan plants, <i>Pleurostylia opposita</i> (Wall) Alston (Celastraceae), <i>Aegle marmelos</i> Correa (Rutaceae) and <i>Excoecaria agallocha</i> Linn. (Euphorbiaceae). After establishing the insecticidal activity of …
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Synthesis and Biosynthesis of Polyketide Natural Products
… in the area pertaining to the biosynthesis of natural products. Both disciplines remain indispensable in providing unique solutions on numerous questions populating the field. Our contributions to this interdisciplinary pursuit have been confined to the biosynthesis of polyketides, a …
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Total synthesis of macrocyclic bisbibenzyl natural products
… the total synthesis of two related macrocyclic natural products, cavicularin and riccardin C. Cavicularin is particularly noteworthy owing to its interesting structure: its 14-membered macrocyclic core imparts sufficient strain on the system to force one of the arenes in this paracycophane to …
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Total Syntheses of 1,2,4-Thiadiazole Natural Products
Only five distinct natural products have been assigned as containing a 1,2,4-thiadiazole motif, of which, dendrodoine (5) and penicilliumthiamine B (19) have been previously synthesised.This thesis describes the total syntheses of all remaining 1,2,4-thiadiazole-containing natural products; …
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Phosphonate natural products from host-associated enterobacteria
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01
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Antiproliferative Natural Products from the Madagascar Rainforest
… program and a continuing search for anticancer natural products from the Madagascar rainforest, twenty extracts from Madagascar were selected for investigation based on their antiproliferative activity. Bioassay-guided fractionation of five of the extracts yielded sixteen new compounds, and …
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Isolation of Natural Products from Casearia nigrescens
… this was the first investigation of the natural products of Casearia nigrescens. The structure of the known compounds was determined by comparison of the NMR, MS, optical rotation, UV, and IR data with the data found in the literature. The structure of casearlucin L was determined by NMR …
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Discovery and Delivery of Bioactive Natural Products
As a part of search for bioactive natural products from the plants in collaboration with the Natural Products Discovery Institute (NPDI), ten plant extracts were investigated for their antiplasmodial activity against Plasmodium falciparum Dd2 strain. Twenty-eight compounds were isolated, and twelve …
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The Bioactivity and Natural Products of Scottish Seaweeds
… has led to seaweed being investigated for their natural product content. Despite over 30 years of research, the majority of species found in Scotland have yet to have their chemistry examined. Extracts of seaweed were tested for antimicrobial activity against marine bacteria. Extracts of Palmaria …
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Molecular studies of natural products and related compounds.
… analysis for the structure elucidation of novel natural products and related compounds. Empirical force field calculations are also used for conformational and biosynthetic studies. An outline of the development of direct methods of X-ray structure analysis is given. The implications of recent …
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Synthetic Investigation of Natural Products Causing Dopaminergic Neurodegeneration
… its structure and biological activity. The natural product was produced from methacrolein and Roche ester starting materials that were elaborated to their respective fragments, a vinyl iodide and a Weinreb amide. These fragments were coupled to form SV-6 and the synthesis allows for many …
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Natural products discovery and characterization via synthetic biology
Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2014-04-09T15:17:47Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 Luo_Yunzi.pdf: 5368178 bytes, checksum: 2f5db8aedc8b652c3a2b8138ab840a22 (MD5)
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Chemical diversification and anticancer activity of natural products
Made available in DSpace on 2014-01-16T18:25:34Z (GMT). No. of bitstreams: 3 Karen_Morrison.pdf: 14532423 bytes, checksum: af6a40d935f8782447ddd84ef12a94ae (MD5) Morrison_Karen.docx: 44256739 bytes, checksum: 6353cc66b66320dd9c663bda8c68747b (MD5) license.txt: 4063 bytes, checksum: …
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