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Showing 1 to 9 of 9 for “"natural product derivatives"”.
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Exploiting alkaloid biosynthesis in Madagascar periwinkle to obtain natural product derivatives and new biocatalysts
Plant alkaloid biosynthesis produces many natural products with medicinal value. For example, vinblastine and vincristine from Catharanthus roseus monoterpene indole alkaloid biosynthesis, and camptothecin derivatives from Ophiorrhiza pumila quinoline alkaloid biosynthesis, are anticancer agents …
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Enantioselective Syntheses and Chemical Investigations of Plant-Derived Bioactive Volatile Compounds
… and related investigations of a variety of natural product derivatives, specifically (+)-nootkatone and jasmone. While the former consists of several independent projects: (a) an enantioselective synthetic route to (+)-nootkatone and derivatives, (b) examination of the valencane ring system, …
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Molecular studies of natural products and related compounds.
… analysis for the structure elucidation of novel natural products and related compounds. Empirical force field calculations are also used for conformational and biosynthetic studies. An outline of the development of direct methods of X-ray structure analysis is given. The implications of recent …
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Exploring Nickel Catalysis in Carbonyl and Alcohol Addition Reactions
… long enabled the synthesis of valuable alcohol derivatives; however, these types of transformations are often plagued by poor functional group tolerance and require harsh reaction conditions. The direct coupling of carbonyls and alcohols with aryl halides is an appealing alternative to access …
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A small molecule-guided structure-function exploration of mitochondrial aldehyde dehydrogenase
… from specialized metabolites, also called natural products. Despite this wealth of medical tradition, modern medicine was unable to precisely characterize the wealth of chemistry and individual bioactivities locked in whole plant tissues until recently. In the last four decades, almost 50% …
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A small molecule synthesizer
… including organic materials, pharmaceuticals, natural products, and natural product derivatives. Specifically, this automated synthesis platform utilizes the iterative cross-coupling (ICC) strategy enabled by the capacity of N-methyliminodiacetic acid (MIDA) to reversibly attenuate the …
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Mechanistic studies of lanthipeptide biosynthesis
Natural products and natural product derivatives have been the leading source of pharmaceutical compounds since the initial application of modern medicine. To fight the increasing occurrence of drug resistance and to reach the ultimate goal of personalized drugs for treating complicated symptoms, …
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!Development of small molecule therapeutics against anti-infectious and anti-cancer drug resistance via structure-based drug design
<p>!Drug discovery typically involves structure-based drug design based on three-dimensional protein structures and hit/lead compound identification and optimization. Herein, this technique was used to overcome several obstacles associated with the developing of antibiotics, anticancer agents, and …
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Cytotoxic Alkaloids from Microcos paniculata with Activity at Neuronal Nicotinic Receptors
Natural products have a long history of use as leads for drug discovery. The World Health Organization (WHO) estimates that in Africa for example, up to 80% of the population relies on plant-derived traditional medicines to help meet primary healthcare needs (WHO, 2002). In the area of cancer, of …