Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 492 for “"natural product"”.
-
Potential Natural Product Phosphodiesterase Inhibitors
… sexual dysfunction and mood regulation. First, naturalproducts were screened by computer modeling of PDE5A1. Second, compounds were isolated from a plant traditionally used as an aphrodisiac. Third, a new synthesis of psychoactive PDE4 inhibitor was attempted. An in silico screen was performed …
-
Biosynthesis of Fluorinated Natural Product Nucleocidin
… calvus. It is one of only six known fluorinated natural products. The 4’-fluorine substituent on nucleocidin requires a unique two-step fluorination mechanism: C-H bond cleavage followed by stereospecific glycosylation of the fluoride ion. Although the gene cluster encoding for nucleocidin has …
-
Natural Product Biosynthesis In Uncultured Bacteria
… methods it is not possible to characterize the natural products encoded by the uncultured majority. The heterologous expression of biosynthetic gene clusters cloned from DNA extracted directly from environmental samples (eDNA) has begun to provide access to the chemical diversity encoded in the …
-
Natural product chemistry in drug discovery
This thesis examines two interrelated aspects of natural product research: the discovery and biological evaluation of plant-derived specialized metabolites as potential drug leads, and the verification of their botanical sources to ensure chemical and taxonomic accuracy. It comprises three …
-
Precursor-Directed Identification of Natural Product Scaffolds
The rapid generation of natural product analogs is a fundamental challenge in both the optimization of medicinal potency and exploration of novel biological activity. Previous work with Streptomyces variabilis has demonstrated that natural products that incorporate non-enzymatic transformation can …
-
Structure Determination of Natural Product Biosynthesis Enzymes
Natural products (NPs) frequently display elaborate molecular frameworks challenging biologists to ascertain the genetic origin and catalytic logic affording intricate NP biosynthesis. Beyond the basic research inspired by multiplicity of NPs discovered thus far, the biological activities …
-
Synthesis Of Natural Product-Based Sphingosine Derivatives
… cancer and other pathological conditions. Natural products that consist of an azetidine ring represents an interesting class of conformationally constrained scaffolds that may serve as effective lead compounds for SK inhibitor development. Hence, the goal of this thesis research was to …
-
Flavin-dependent Enzymes in Natural Product Biosynthesis
Natural products are biologically active metabolites produced by fungi, bacteria, and plants that have an extended application in pharmaceutical and chemical industries. Because of their chemical versatility, flavoenzymes are commonly involved in natural product biosynthetic pathways. This has …
-
Diverse enzyme reactions in phosphonate natural product biosynthesis
… biosynthetic gene clusters encoding phosphonate natural products have been characterized by mining of microbial genomes. Phosphonates, which are characterized by their hydrolytically stable carbon-phosphorus bond, are prevalent in everyday life, such as in commercially available herbicides and an …
-
Natural product derivative activates autophagy in cancer cells
Artemisinin, a natural product and its derivatives are potent antimalarial compounds, which have shown anticancer activity. In this study, we further characterized a novel artemisinin derivative namely EXP57EA which was previously designed and synthesized by the Chemistry Department at the …
-
Polymers from the natural product betulin : a microstructural investigation
… thesis, microporous polymers from an abundant natural resource, betulin, will be presented. Betulin is a large-scale byproduct of the wood industry, and its content in birch bark can reach 30 wt.%. Based on its rigid structure, polymer networks with intrinsic microporosity could be synthesized …
-
Applications of the achmatowicz rearrangement in natural product synthesis
The structurally related PM-94128 and Ajudazols A and B exhibit differing biological activities but share the isocoumarin core structure. PM-94128 belongs to a large family of compounds known as the aminodihydroisocoumarins and was isolated in 1997. It has been shown to be an inhibitor of DNA and …
-
Investigation of metal mediated reactions for natural product synthesis
… has been applied for the synthesis of several natural products including dihydroxylated-amino acids. Further investigation of substrates for the rearrangement led to the synthesis of other substituted trichloroacetimidates. Rearrangement of these compounds demonstrated the role of steric strain …
-
Studies in Marine Natural Product Synthesis, Isolation and Ecology
… thennew synthetic route, including the antiviral natural product 11-hydroxyascididemin. 11-Methoxyascididemin was selected for hollow fiber evaluation. Two bromine containing ring D analogues were prepared, including the antifungal natural product 2-bromoleptoclinidinone. A crystal structure on …
-
Genomics as a tool for natural product structure elucidation
Natural product discovery is in the midst of a transition from a largely serendipity-based effort to an informatics-driven one. For most of the 20th century, natural product discovery relied on genome-blind bioassay-guided isolation. This was initially exceptionally productive, yielding the golden …
-
Enabling Natural Product Biosynthesis With Novel Synthetic Biology Tools
… several novel synthetic biology tools for natural product research and development. The first tool is DNA assembler, which allows rapid construction of large recombinant DNAs in a single-step fashion through yeast in vivo homologous recombination. Further applications of DNA assembler to …
-
Discovery, enzymology, and engineering of bacterial natural product pathways
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01
-
Investigations of metalloenzymes involved in bacterial natural product biosynthesis
Just as the structures of bacterial natural products have long been a source of inspiration for new developments in drug discovery and organic synthesis, so have investigations of their biosynthetic pathways led to the discovery of countless new enzyme-catalyzed reactions that open new frontiers of …
-
Application of Mn(III) Oxidative Cyclizations to Natural Product Synthesis
… as a possible route towards a family of natural products called the flinderoles. Work on the construction of the core of several indole alkaloids from the genus Tabernaemontana, including tronocarpine, chippiine, and dippinine B, will be explored with utilization of manganese(III) …
Page 1 of 25