Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 69 for “"nasopharyngeal"”.
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The Role of MicroRNAs in Human Nasopharyngeal Carcinoma
… in locoregional control in the contemporary era, nasopharyngeal carcinoma (NPC) patients still suffer from a significant risk of distant metastasis (DM). Thus, developing methods to better identify and treat NPC patients at risk of DM is of paramount importance. MicroRNAs (miRNAs) have been shown …
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Genetic and gene expression analysis of nasopharyngeal carcinoma (NPC)
… and differential RNA expression profiles in Nasopharyngeal carcinoma (NPC). Gene expression profiles identified a large number of differentially regulated genes involved in diverse functional processes, while genetic analysis detected extensive genomic abnormalities including large and small, …
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Clinical pharmacokinetics of low dose paclitaxel in Asian patients with nasopharyngeal carcinoma
… paclitaxel in Asian patients with WHO Stage III nasopharyngeal carcinoma treated with a chemo-radiation regimen were determined and correlated with subjecta??s demographics, clinical parameters, outcome with the intent of optimizing therapeutic benefit to risk ratio in clinical use. Chemotherapy, …
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The molecular diagnosis of Pneumocystis pneumonia in children using nasopharyngeal aspirate samples
Pneumocystis pneumonia (PCP) is an important opportunistic infection caused by thefungus Pneumocystis jirovecii. The incidence of PCP in sub-Saharan Africa is on theincrease. This is due to the progression of the HIV-pandemic and limited access to healthcare facilities, specific highly active …
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Assessing the Effect of “Time of Birth” on Nasopharyngeal Microbial Load in Infants
… followed up to 1 year of age. For measurement of nasopharyngeal microbial abundance, approximately seven specimens were taken per subject. The total number of patients and specimens in the dataset are 139 and 948 respectively. The outcome variable was the log-transformed relative abundance of …
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Studies of the anti-cancer potential of flavonoids in Human Nasopharyngeal carcinoma cells
… two flavonoids namely luteolin and quercetin on nasopharyngeal carcinoma (NPC) using two NPC cell lines, HK1 and CNE2. We first identified the mechanisms leading to quercetin-mediated cell cycle arrest in NPC cells. Quercetin was able to inhibit E2F-1 transcriptional activity, thus preventing the …
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Temporal interactions of microbiota in longitudinal nasopharyngeal samples and association with lower respiratory tract infection
… is widely accepted that infection is preceded by nasopharyngeal (NP) colonisation with bacteria and that NP flora develop early in childhood (during the first year of life). The presence of multiple NP bacteria results in competitive and synergistic associations, however temporal organism …
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Nasopharyngeal colonization dynamics with Streptococcus pneumoniae and associated antimicrobial resistance in a South African birth cohort
Introduction: Nasopharyngeal (NP) colonization by Streptococcus pneumoniae (the pneumococcus) precedes the development of respiratory tract infection. Colonization by antimicrobial-resistant pneumococci, especially in infants, is a major public health concern as pneumococcus is a frequent cause of …
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Treatment outcomes of Epstein-Barr virus associated nasopharyngeal carcinoma with three-dimensional conformal radiotherapy: A retrospective review
… outcomes of Epstein-Barr virus (EBV) associated nasopharyngeal carcinoma (NPC) largely comes from endemic regions. There is limited literature available regarding the epidemiology and treatment outcomes of EBV associated NPC in South Africa. Aim: The primary aim of the study was to determine …
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A BIOMARKER ENRICHMENT PHASE II TRIAL OF 177LU-DOTATATE IN METASTATIC NASOPHARYNGEAL CANCER WITH A SAFETY RUN-IN
Nasopharyngeal cancer (NPC) is endemic in Southeast Asia. There is a lack of effective targeted treatments for NPC. In this thesis, we investigate the prevalence and prognostic significance of somatostatin receptor 2 (SSTR2) expression in an international study comprising multiple clinical cohorts …
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Met Inactivation by S-allylcysteine Suppresses Migration and Invasion of Nasopharyngeal Cancer Cells Induced by hepatocyte growth factor
… zymography assays were performed in the human nasopharyngeal cancer cell lines HNE1 and HONE1 treated with SAC (0, 10, 20, or 40 mM) and hepatocyte growth factor (HGF). This study showed that SAC could suppress the migration and invasion of HNE1 and HONE1 cell lines by inhibiting p-Met. An …
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An investigation into the regulation and expression of the tumour suppressor gene clusterin in oral, cervical and nasopharyngeal cancer
… Down-regulation of CLU was demonstrated in nasopharyngeal cancer (NPC) and oral cancer and loss of one CLU allele and methylation of the other in the NPC cell line C666-1. This defect has been repaired in this NPC cell line and showed that overexpression of the nuclear isoform of CLU …
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Nasopharyngeal carriage with Staphylococcus aureus in healthy children during the first year of life - The Drakenstein Child Health study
… structure and carriage patterns of S. aureus nasopharyngeal carriage among healthy South African infants and their mothers participating in an intensively sampled cohort. Methods: Nasopharyngeal swabs (NP) were collected on the day of birth from 137 mother-infant pairs and two-weekly …
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Longitudinal colonisation by Streptococcus pneumoniae and nasopharyngeal microbial interactions in health and disease: a South African birth cohort study
… is the most common cause of childhood pneumonia. Nasopharyngeal (NP) colonization by the pneumococcus is a necessary first step in the pathogenesis of pneumonia and yet the dynamic nature of pneumococcal colonization remains incompletely understood. In children, asymptomatic colonization of the …
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The yield of nasopharyngeal bacteria from culture compared to polymerase chain reaction in South African children with lower respiratory tract infection
… from culture and the FTDResp33 multiplex PCR of nasopharyngeal swabs (NPs) during LRTI episodes in children, in the Drakenstein Child Health Study. Methods At each episode of LRTI, 2 NPs were obtained, one for culture and one for PCR testing. Bacterial yields and concordance for the 5 commonest …
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Modulation of innate immune responses in nasopharyngeal epithelial cells by the Epstein-Barr virus (EBV)-encoded latent membrane proteins LMP2A and LMP2B
The Epstein-Barr virus (EBV)-encoded Latent membrane proteins (LMP) 2A and LMP2B are frequently expressed in a number of EBV-associated malignancies. Although the true function of these proteins remains to be elucidated, LMP2A appears to function as a surrogate B-cell receptor in B-cells, …
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Efficiency of Monoclonal Antibodies to Detect Respiratory Virus Antigens in Clinical Specimens
… in Bismarck, North Dakota.</p> <p>Throat swab, nasopharyngeal swabs and nasopharyngeal washes were excellent specimens for studying viral epidemiology; virus isolation rates were 7.7%, 33.2%, and 39.7%, respectively. Yearly epidemics of respiratory syncytial virus and influenza were observed. In …
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An investigation in the seasonal patterns of bacterial colonisation in childhood pneumonia
… focuses on exploring the effects of season on nasopharyngeal carriage of pathogens occurring in the nasopharynx of young children with and without the occurrence of lower respiratory tract infection. Using logistic mixed effects models and taking into account the repeated measure structure of …
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Η ανοσοθεραπεία ως θεραπεία πρώτης γραμμής για υποτροπιάζον ή μεταστατικό ρινοφαρυγγικό καρκίνωμα: Μια αφηγηματική ανασκόπηση των διαθέσιμων δεδομένων / Immunotherapy as first-line treatment for recurrent or metastatic nasopharyngeal carcinoma: A narrative review of the evidence
Το ρινοφαρυγγικό καρκίνωμα (NPC) αποτελεί μια βιολογικά διακριτή κακοήθεια της κεφαλής και του τραχήλου, με ισχυρή συσχέτιση με τον ιό Epstein–Barr (EBV), έντονη γεωγραφική κατανομή και ιδιαίτερα ανοσολογικά χαρακτηριστικά. Επειδή συχνά διαγιγνώσκεται σε προχωρημένο στάδιο, σημαντικό ποσοστό …
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The effect of long-term azithromycin treatment on the respiratory microbiota of HIV-infected children with chronic lung disease
… with salbutamol) in Zimbabwe and Malawi. Paired nasopharyngeal swabs and sputa were collected at baseline, 48 and 72 weeks from participants randomised to receive 48 weeks of once-weekly oral azithromycin or placebo and followed post- intervention until 72 weeks from baseline. Baseline samples …
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