Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"nascent chains"”.
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Making Ribosomes: Biochemical and Structural Studies of Early Ribosome Biogenesis in Yeast
… factors bind co-transcriptionally to the nascent chains of pre-ribosomal RNA and coordinate its correct folding, modification and cleavage. While most ribosome assembly factors have been identified, the function of numerous factors is still unknown. The timing of their involvement in …
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In vitro studies on the SecA involvement in the assembly of an integral membrane protein with large hydrophilic domain
… <br> We used as a substrate ribosome-associated nascent chains of Momp2. Momp2 is a hybrid protein encompassing an N-terminal transmembrane domain and a large translocated moiety. Momp2 is one of the proteins whose integration via the transmembrane domain takes place in a SRP/FtsY dependent …
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Structural Studies of Protein Transport
… with the transmembrane domains (TMDs) of nascent IMPs. Sec61 was co-purified with stalled ribosome-nascent chains which encoded TMDs of each orientation, N-in and N-out, that appear biochemically to bind to a recognition site in Sec61. Cryo-EM of these complexes showed that the N-in TMD …
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In vitro-Untersuchungen zum Sekretionsmechanismus der beta-Lactamase in Escherichia coli
Das gramnegative Bakterium Escherichia coli besitzt vier verschiedene Zellkompartimente: das Cytoplasma, die Cytoplasmamembran (Innenmembran), den periplasmatischen Raum sowie die Außenmembran. Für die Zielsteuerung (Targeting) ungefalteter Proteine an die Innenmembran und ihren anschließenden …
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ISG15 conjugation : cellular targets and the lysine selectivity of HERC5
… associates with polysomes and appears to target nascent polypeptides in a near stochastic manner, with limited substrate selectivity. A model for HERC5 function is that, in the context of a type I interferon response, newly translated viral proteins are the biologically relevant targets of …