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Showing 1 to 7 of 7 for “"narciclasine"”.
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Synthesis of unnatural analogues of pancratistatin and narciclasine
… and A-ring heterocyclic analogues of narciclasine are discussed. Evaluation of the new analogues as cancer growth inhibitory agents is also described
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Approaches towards C-10-hydroxylated analogues of narciclasine
… of a C10-benzyloxy unnatural derivative of narciclasine. The described approach involves the use of homochiral cyclohexadiene diols, products of the biocatalytic transformation of aromatic compounds, as precursors to ring C, and of highly oxygenated aromatic molecules to construct ring A. …
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Synthesis of unnatural analogues of narciclasine: Chemoenzymatic synthesis of 2-epi-1-hydroxymethylnarciclasine
… to the synthesis of novel C-1 analogues of narciclasine has been developed. The synthesis relies on chemoenzymatic dihydroxylation of an arene, Stille coupling, and an intramolecular Heck reaction to affect key transformations. The synthesis of the targeted C-1 analogues addresses a gap in …
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Dearomative transformations in synthesis: I. Dearomative dihydroxylation with arenophiles II. Total synthesis of lycoricidine and narciclasine III. Towards the total synthesis of collybolide
… describes the synthesis of lycoricidine and narciclasine, two Amaryllidaceae alkaloids with potent anti-cancer activity. Through the application of a Narasaka variant of our dearomative dihydroxylation reaction and a key Suzuki reaction, we have enabled concise access to a key intermediate …
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Total synthesis enabled by nickel-catalyzed transformations: Dearomative carboamination and methylenecyclopropane annulation
… total synthesis of the remaining two alkaloids, narciclasine and lycoricidine. The C-7 cupration reaction was used to synthesize a library of analogs previously inaccessible with other reported sequences. The new analogs were found to be equipotent and significantly more soluble in water than the …
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Controlled synthesis of complex organic molecules and nanomaterials: Engaging chemical properties for biological applications
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-09-16 without embargo terms
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Controlled synthesis of complex organic molecules and nanomaterials: Engaging chemical properties for biological applications
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-09-16 without embargo terms