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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"naphthalimide"”.
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Squaramide-Naphthalimide Conjugates as Potential Self-Assembled Materials and as DNA Binders
This thesis entitled ‘Squaramide-Naphthalimide Conjugates as Potential Self-Assembled Materials and as DNA Binders’ is divided in 7 chapters. Chapter 1 presents an introduction to DNA, its function and structure. Various DNA binders were introduced in this section, specifically currently studied …
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Singlet oxygen generating luminescent lanthanide complexes with naphthalimide-based and oligothiophene-based sensitizers
Luminescent lanthanide (LnIII) complexes that also generate singlet oxygen (1O2) are of interest to medical, biological, and analytical fields, as they can provide cytotoxicity and luminescence using light excitation. Because of the interest in these compounds, systematic studies were used to help …
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Study of Polyphenols and Naphthalimide Analogs As Inhibitors of Amyloid- β Protein Aggregation In Alzheimer'S Disease
… via monomer addition. </p> <p> Based on a novel naphthalimide analog acetylcholinesterase inhibitior (AChEI), G-II-19, synthesized by Jie Gao in Dr. Chapman's laboratory, a group of naphthalimide analogs was synthesized as potential dual-function inhibitors for AChE and Aβ aggregation. …
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Synthesis and Characterization of Metal-Organic Frameworks Organized by the Strong π...π Stacking 1,8-Naphthalimide Synthon
… forces has been prepared. The ligand, (1,8- naphthalimide)CH2C6H4CH2OCH2C(pz)3 (Ltris, pz = pyrazolyl ring), contains both a</p> <p>tris(pyrazolyl)methane coordination unit and a 1,8-naphthalimide strong π...π stacking unit. The reactions of iron(II), copper(II) and cadmium(II) …
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New tools derived from the solvatochromic 4-N,N-dimethylamino-1,8-naphthalimide fluorophore for the detection of biomolecular interactions
… on the solvatochromic 4-N,Ndimethylamino- 1,8-naphthalimide (4-DMN) fluorophore for the study of biomolecular interactions. This fluorophore is distinctive in that it yields very few compromises by combining many of the key elements required of a good fluorescent tool.
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The synthesis and fluorescence properties of some substiuted naphthalimides
A number of known and novel naphthalimide derivatives have been synthesised. For many of the known compounds, improvements in their syntheses have been achieved in terms of higher yield and/or milder reaction conditions. Some of the novel compounds have been prepared with the aim of improving the …
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Explorative studies to understand if aldehyde dehydrogenase (ALDH) expression in colon cancer can be exploited as a target for therapeutic intervention. Expression profiling of ALDH7A1 in colorectal cancer
… while also investigating a novel library of naphthalimide-based compounds with potential to be used as hypoxia activated prodrugs (HAPs, and longer term as ALDH-targeting fluorescent probes. The current study is the first study to compare both Nigerian and UK patients with CRC disease. …
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Aspects of bioorganic chemistry - a). Development of caffeine-aptamer for coffee decaffeination; b). Study of 1,8-naphthalimide derivatives as fluorescent probes; c). Encapsulation of DNA by silica nanoparticles
… future aptamer selection. The development of 1,8-naphthalimide derivatives was motivated by an ability to stain biomolecules based on differences in their hydrophobicity. 1,8-naphthalimide derivatives were synthesized, and their photophysical and staining properties were investigated. The …
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Model-Based Measures Of Interrater Agreement
… results, a series of JWS derivatives and 1,8-naphthalimide analogs were synthesized as potential MTDLs and tested for their AChE inhibitory, muscarinic receptor binding, A&beta aggregation inhibitory and iNOS inhibitory activities. The structure-activity relationships of these JWS derivatives …
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Stretching Collagen: Using Fluorophores in Collagen Mimetic Peptides as a Proposed Enantiomeric Sorting Technique
… This research aims to create two fluorescent naphthalimide isomers to be embedded within collagen mimetic peptides. These isomers are designed to act as walls of a ‘capsule’ that could potentially trap drug molecules, while reporting that they have done so via changes in their emission …
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Transformation of biomass carbohydrates by transition metal catalysts
… form a triazole. The alkyne group is part of a naphthalimide compound that has strong fluorescent properties due to its aromatic structure. By adding a triazole to the fluorescent naphthalimide complex, a much stronger fluorescent signal can be generated. By reproducing this strategy with plant …
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The synthesis and study of novel fluorescence probes for Nitroreductase
… of novel fluorescence sensors where variation of naphthalimide substituents is described. The synthesis of each compound is discussed, followed by an evaluation of their photophysical characteristics and response to nitroreductase (NTR) in a biological setting. Chapter 3 explores synthetic …
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Synthesis, Self-Assembly and Photophysical Properties of Multichromophoric Systems
… linkers and short alkyl spacers with either naphthalimides or 4-(5-hexyl-2,2’-bithiophene)-naphthalimides. The employed universal synthetic route allows for a versatile functionalization of carbonyl-bridged triarylamines. Both multichromophoric compounds show efficient energy transfer, …
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Synthesis Of Non-Natural Fmoc-Protected Amino Acids To Provide Novel Fluorescent Anion Probes And Their Incorporation Into Synthetic Peptides
… a Curtis Rearrangement. An N-substituted-4-amino-naphthalimide was chosen as the chromophore due to its ability to absorb and emit light at a significantly longer wavelength than those produced by naturally occurring amino acids. The fluorescence provides an indirect insight into the binding …
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Bio based photocurable polymers for advanced applications
… cellulose was functionalized with fluorescent naphthalimide moieties, yielding self-standing sensors responsive to formaldehyde and hydrogen sulfide in both gaseous and aqueous environments. The feasibility of using waste-derived cellulose obtained through selective purification was also …
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Catching a glimpse: the visualization of Mycobacterium tuberculosis from TB patient bioaerosols
… cell wall probe, 4-N,Ndimethylamino-1,8-naphthalimide-trehalose (DMN-tre), with the arraying of bioaerosol samples on bespoke nanowell devices amenable to fluorescence microscopy. With this method, a median of 14 live Mtb bacilli (range 0-36) were detected in 90% of confirmed TB patients …
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High Temperature Polymers for Proton Exchange Membrane Fuel Cells
… poly(arylene ether) copolymers containing either naphthalimide, benzoxazole or benzimidazole moieties were synthesized via direct copolymerization. The ion exchange capacity (IEC) was varied by simply changing the ratio of disulfonated monomer to nonsulfonated monomer in the copolymerization step. …
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Development and application of chemical tools for investigating dynamic processes in cell migration
… fluorophore 4-N,N-dimethylamino-1,8-naphthalimide has been incorporated into a protein fragment that binds only the activated conformation of Cdc42. This sensor reports Cdc42 activation through significant increases in fluorescence and has been applied in a cellular context to monitor …
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Photophysics of Biological and Synthetic Multichromophoric Systems : Spectroscopic Investigations of Bacterial Light-Harvesting Complexes and of Carbonyl-Bridged Triarylamine Derivatives
… that is decorated with either three peripheral naphthalimide (NI) molecules or three peripheral 4-(5-hexyl-2,2’-bithiophene)-naphthalimide (NIBT) molecules. These compounds are abbreviated as CBT-NI and CBT-NIBT, respectively. Additionally isolated CBT, NI and NIBT were investigated as reference …
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Synthese und Charakterisierung allosterer Modulatoren muscarinischer M2-Rezeptoren : Strukturvariationen der Bis(ammonium)alkan-Verbindung W84
… fluoreszierenden Eigenschaften N-substituierter Naphthalimide könnten zur direkten Charakterisierung allosterer Interaktionen oder zur Verfolgung des „Rezeptor-Traffickings“ mittels Fluoreszenzkorrelationsspektroskopie genutzt werden. Deshalb wurden in Position 3 und 4 des Naphthalimidringes des …
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