Global ETD Search
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Showing 1 to 8 of 8 for “"nanovaccine"”.
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Universal room-temperature stable influenza A nanovaccine
… forms the basis of a universal IAV subunit nanovaccine formulation composed of a novel equine IAV antigen and IAV nucleoprotein delivered via polyanhydride nanoparticles and pentablock copolymer micelles. This rationally designed subunit vaccine formulation was evaluated to determine both …
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Congenital Chagas Murine Model Development and Nanovaccine Efficacy Against Maternal-fetal Trypanosoma cruzi Pathogenesis
… model of cCD to test the efficacy of a DNA nanovaccine developed by our laboratory. In this dissertation, we demonstrate that Tc infection in female mice delayed the initiation of pregnancy, reduced fertility rate, and resulted in vertical transmission of the parasite to the offspring. Pups …
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Factors that Affect the Immunogenicity of Lipid-PLGA Nanoparticle-Based Nanovaccines against Nicotine Addiction
… the immunological efficacy of the nicotine nanovaccine. First, 100 nm nanovaccine was found to elicit a significantly higher anti-nicotine antibody titer than the 500 nm nanovaccine. Secondly, the high-density nanovaccine exhibited a better immunological efficacy than the low- and …
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Development of a Nanoparticle Vaccine Delivery System with Polymeric Oral Adjuvants for Poultry
… 4. Compare the abilities of the killed HEV nanovaccine, killed HEV with loose gelatin and chitosan polymers (no nanoparticle), and a live HEV commercial vaccine to induce textit{in vivo} seroconversion, protective immunity, and side effects during clinical and challenge studies in turkeys We …
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Evaluation of a gold nanoparticle platform as highly immunogenic and protective therapy against Burkholderia mallei, B. pseudomallei, and Enterohemorrhagic Escherichia coli O157:H7
Burkholderia mallei (Bm) and B. pseudomallei (Bpm) are facultative intracellular pathogens and the causative agents of glanders and melioidosis. At present, effective vaccines for the prevention of glanders, or melioidosis in humans, are not available. However, renewed attention has been directed …
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Precision Adjuvant Design Enabling Tailored Nanoparticle Immunization Platforms for Oxycodone and Other Substance Abuse Vaccines
Substance use disorders (SUDs) constitute a growing global health burden, with opioids responsible for nearly two‑thirds of SUD‑related fatalities in the United States. Current pharmacotherapies for opioid use disorder are limited by adherence challenges, diversion risks, and inconsistent efficacy. …
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Expression and Purification of the C-Terminal Domain of Porcine Epidemic Diarrhea Virus (PEDV) S1 Protein
Porcine Epidemic Diarrhea Virus (PEDV) was first detected in Europe in the 1970s, but did not emerge in the United States until 2013. When it arrived, it ran rampant due to the lack of previous exposure, causing the death of 7-8 million neonatal piglets and $900 million to $1.8 billion in losses to …
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Cooperativity: Physiologic Cornerstone and Emerging Therapeutic Design Principle
The content of this work is based on the previously published articles that are cited below.