Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"nanotopography"”.
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Use of comparative proteomics to study a novel osteogenic nanotopography
The principal aim of this thesis was to investigate the ability of surface topography in inducing bone cell differentiation for biomedical purposes. In orthopedic research, regeneration of bone defects can be performed in vitro using biomaterials. Third generation biomaterials aim not only to …
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Improved nanotopography sensing via temperature control of a heated atomic force microscope cantilever
This thesis reports thermal nanotopography sensing using a heated atomic force microscope cantilever with a sensitivity as high as 4.68 mV/nm, which is two orders of magnitude higher than previously published results for heated cantilevers. The sensitivity improvement arises from closed-loop …
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Heated atomic force microscope cantilever with high resistivity and improved temperature sensitivity for nanotopography sensing
This thesis reports thermal nanotopography sensing with an atomic force microscope using a high-resistivity (HR) heated cantilever and a previously studied low-resistivity (LR) heated cantilever, with respective heater doping concentrations of 1 x 10^16 cm^-3 and 3 x 10^17 cm^-3. The HR cantilever …
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Wafer bonding : mechanics-based models and experiments
… of mid-spatial wavelength height variations (nanotopography) on bonding is examined through a combination of modeling and experiments. The experiments and analysis provide a route for characterizing nanotopography and assessing its impact on bonding. The accuracy of the wafer bonded double …
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Bionanoparticles as Viable Substrates to Promote Osteogenic Differentiation of Bone Marrow Stromal Cells
… dissertation focuses on studying the effect of nanotopography on the promotion of osteogenic differentiation of BMSCs. The nanoptopographies were created by coating 2D substrates with turnip yellow mosaic virus (TYMV) and tobacco mosaic virus (TMV) bionanoparticles. TYMV and TMV, both are …
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COMBINATORIAL DEVELOPMENT OF NANOSTRUCTURED MATERIAL LIBRARIES FOR THE STUDY OF CELL SUBSTRATE INTERACTION
… behavior on engineered substrates comprising nanotopography. This thesis highlights the development of gradients of nanostructured titania thin films attributing different roughness without influencing the chemical nature in order to understand the physical cues regulating primary cellular …
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Physical understanding and modeling of chemical mechanical planarization in dielectric materials
… problems, including design for manufacturing, nanotopography impact, wafer edge roll-off effects, and motor current based endpoint detection.
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The influence of nanotopographical structures on osteoblast adhesion formation and the functional response of mesenchymal stem cell populations
… populations cultured on these nanotopographies. Nanotopography differentially affected the formation of adhesions in HOBs and induced significant changes in genetic expression of MSCs on experimental substrates. Nanopit type topographies fabricated by electron beam lithography were shown to …
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Directed Cell Migration: From Single Cells to Collectively Moving Cell Groups
… guidance–as dynamic sensors of surface nanotopography. The dynamics of guided actin waves were measured to build and test predictive models of contact guidance. The distributions of actin-wave propagation speed and direction were obtained from experimental observations of cell migration …
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Development of microcantilever mid-infrared detectors and sources and their application in infrared spectroscopy
… and also detect IR light. This study reports nanotopography and IR microspectroscopy measurements performed using a bimaterial cantilever in the same AFM system. This system uses micrometer scale engineered skin and three-dimensional cell culture samples for the demonstration. Finally, this …
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Biosynthesis of polyhydroxyalkanoates and their medical applications
… with increased compressive strength, surface nanotopography and bioactivity as compared to the original 45S5Bioglass® scaffold. The multifunctional scaffold was also successfully used as a drug delivery vehicle. Hence, this multifunctional scaffold can be used to deliver drugs, proteins or …
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IN VITRO MODULATION OF HUMAN CORNEAL ENDOTHELIAL CELL BEHAVIOR VIA TOPOGRAPHICAL AND BIOCHEMICAL CUES
Human corneal endothelium plays important roles in maintaining corneal transparency. However, corneal endothelial cells do not proliferate in vivo, resulting in decreased cell density over time. While the endothelium normally can sustain its function for a lifetime, trauma and diseases can result …
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NANOSTRUCTURED COMPOSITE FILMS FOR BRAIN-MACHINE INTERFACE APPLICATIONS
… 10.3390/mi12010094. [10] A. Previdi et al., ‘Nanotopography and Microconfinement Impact on Primary Hippocampal Astrocyte Morphology, Cytoskeleton and Spontaneous Calcium Wave Signalling’, Cells, vol. 12, no. 2, p. 293, Jan. 2023, doi: 10.3390/cells12020293. [11] F. Profumo, F. Borghi, A. …
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Fundamentals of heat transfer and thermal-mechanical control for improved atomic force microscopy
This dissertation presents novel atomic force microscope (AFM) cantilevers and cantilever technology that improve the measurement rate and precision of AFM. AFM cantilevers with integrated heater-thermometers can generate and sense heat flows to measure and manipulate matter at the nanometer scale. …