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Showing 1 to 16 of 16 for “"nanosuspensions"”.
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NANOSUSPENSIONS-BASED ORAL DELIVERY PLATFORMS - NANODPS
In questa tesi di dottorato è stato studiato il potenziale delle nanosospensioni (NS) come intermedi di produzione per il miglioramento della solubilità e, di conseguenza, della biodisponibilità orale di farmaci scarsamente solubili in acqua, attraverso lo sviluppo di approcci tecnologici per la …
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Diethylstilbestrol Nanosuspensions for Prostate Cancer: Subcutaneous Sustained Release Formulations and Pre-clinical PK/PD Evaluations
… demonstrated a sustained release of DES from the nanosuspensions as compared to that of the DES co-solvent preparation. Also, the in vitro release of DES was inversely dependent on the particle size of the nanosuspensions. The pharmacokinetic studies in the Sprague Dawley rats demonstrated that as …
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A preliminary investigation of the sterile-filterability of BCS class II drug nanosuspensions prepared via wet stirred media milling
… filtration of drug nanoparticle suspensions (nanosuspensions) is critically needed for administration by intravenous delivery route. Avoiding gamma irradiation and high temperatures, sterile filtration could be an effective process to sterilize drug nanosuspensions. On the other hand, two …
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Nanocarriers for drug targeting and improved bioavailability
… on two main topics: - Drug delivery to brain - Nanosuspensions for different applications The objective of the first topic was the development of liposomes to which anti-TfR-monoclonal antibodies (Ox26) or lactoferrin was bounded to transport the selective NK3 receptor agonist senktide to CNS …
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Assessment of nanocomposites vs. amorphous solid dispersions for dissolution enhancement of bcs class ii drugs
… of nanocomposites prepared via dying of the drug nanosuspensions, and (3) assess the dissolution enhancement imparted by drug nanocomposites vs. ASDs prepared via drying of drug nanosuspensions by a novel nanoextrusion process, which allows for a scientific, head-to-head assessment of the two …
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Crystal engineering, Bio Pharmaceutics and Cell biology of active pharmaceutical ingredient (drug) nanoparticles. Formation and cell interaction of hydrocortisone and prednisolone nanoparticles.
… drugs. In the first part of the current study, nanosuspensions of two of hydrophobic steroid drugs: hydrocortisone and prednisolone were produced. Nanosuspensions were prepared using a bottom-up approach: the anti-solvent precipitation method using microfluidic reactors. Surface modification was …
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Nanosized systems for efficient delivery of antitumoral and anti-inflammatory drugs
… two different nanosized systems, liposomes and nanosuspensions. Liposomes were develop with the aim to improve the Triiodothyronine (T3) delivery to hepatic cancer cells and nanosuspensions were proposed to enhance dermal bioavailability of Diclofenac acid, a potent nonsteroidal …
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Application of raman spectroscopy in pharmaceuticals
… thin gel films made from micronized powders and nanosuspensions. By employing complementary near infrared and Raman imaging for newly developed films, it was possible to extract valuable information on the spatial distribution and crystallinity of the embedded particles in a polymeric matrix at …
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Batch and continuous production of stable dense suspensions of drug nanoparticles in a wet stirred media mill
… investigation of the production of Griseofulvin nanosuspensions in a wet stirred media mill operating in both the recirculation and continuous modes has been conducted to address the aforementioned fundamental challenges. Griseofulvin has been selected as a model poorly water-soluble BCS Class II …
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Preparation and stability of organic nanocrystals. Experimental and molecular simulation studies.
… and control of particle size distribution for nanosuspensions still need to be addressed. The aim of this study was to revisit the simplest approach of re-precipitation and to identify the critical parameters, including the effect of different stabilisers as well as process conditions. We …
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Pure Insulin Nanoparticle Agglomerates for Pulmonary Delivery
… pure insulin microparticles can be produced from nanosuspensions with minimal processing steps and with suitable properties for deposition in the peripheral lung.
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Particle Manipulation Via Optical Forces and Engineering Soft-Matter Systems With Tunable Nonlinearities.
… more than 25 diffraction lengths, in colloidal nanosuspensions.
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Formulation development of a novel antivirulence compound for enhanced pharmacokinetic properties
… to 28.6% and 22.7%, respectively. The C790 nanosuspensions, in particular the one with small plate-like particles, has demonstrated promising clinical potential as oral and intravenous formulations.
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Mechanisms of polymer adsorption in nanoparticle stabilization for poorly water soluble compounds
… mechanism of nanoparticle stabilization. Drug nanosuspensions were prepared by wet milling of drug with water as medium and polymers as stabilizers. Block copolymers were evaluated based on varying the hydrophobic and hydrophilic amounts, polymer concentration, and polymer affinity differences …
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Drug nanosizing using microfluidic reactors. Development, characterisation and evaluation of corticosteroids nano-sized particles for optimised drug delivery.
… the potential of preparing pharmaceutical nanosuspensions using microfluidic reactors was researched. A hydrocortisone (HC) nanosuspension (NS) was prepared by introducing the generated drug particles into an aqueous solution of stabilizers stirred at high speed with a propeller mixer. A …
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Improving CNS Delivery of Genistein for the Treatment of Sanfilippo Syndrome
… of genistein formulation. Methods: Genistein nanosuspensions were prepared by wet milling technique and characterized in order to select the most stable and uniform formulation with minimal particle size. Transcellular transport studies were carried out using Caco-2 monolayer to compare …