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Showing 1 to 13 of 13 for “"nanosuspension"”.
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Nanocarriers for drug targeting and improved bioavailability
… on two main topics: - Drug delivery to brain - Nanosuspensions for different applications The objective of the first topic was the development of liposomes to which anti-TfR-monoclonal antibodies (Ox26) or lactoferrin was bounded to transport the selective NK3 receptor agonist senktide to CNS …
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Diethylstilbestrol Nanosuspensions for Prostate Cancer: Subcutaneous Sustained Release Formulations and Pre-clinical PK/PD Evaluations
… was to develop a subcutaneous sustained release nanosuspension formulation of DES, which would circumvent the first pass effect of DES, potentially reducing the thromboembolic and cardiovascular complications and maintaining or improving the efficacy of DES by sustaining its release. Subcutaneous …
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Nanosized systems for efficient delivery of antitumoral and anti-inflammatory drugs
… two different nanosized systems, liposomes and nanosuspensions. Liposomes were develop with the aim to improve the Triiodothyronine (T3) delivery to hepatic cancer cells and nanosuspensions were proposed to enhance dermal bioavailability of Diclofenac acid, a potent nonsteroidal …
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Improving CNS Delivery of Genistein for the Treatment of Sanfilippo Syndrome
… of genistein formulation. Methods: Genistein nanosuspensions were prepared by wet milling technique and characterized in order to select the most stable and uniform formulation with minimal particle size. Transcellular transport studies were carried out using Caco-2 monolayer to compare …
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Formulation and dissolution of polymer strip films for the delivery of poorly water-soluble drug nanoparticles
… nanoparticles by varying the drug loading in the nanosuspension from which the nanoparticles are taken and the polymer-to-nanosuspension mixing ratio. All films up to 50 wt% drug loading show good content uniformity and drug nanoparticle redispersibility, suggesting that high drug loading can …
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Assessment of nanocomposites vs. amorphous solid dispersions for dissolution enhancement of bcs class ii drugs
… production of drug nanoparticles in stable nanosuspension form, (2) elucidate the impact of various classes dispersants on drug release rate and mechanisms during the redispersion-dissolution of nanocomposites prepared via dying of the drug nanosuspensions, and (3) assess the dissolution …
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Additive Manufacturing of Copper via Binder Jetting of Copper Nanoparticle Inks
… in an existing organic binder, (ii) an inorganic nanosuspension, and (iii) a Metal-Organic-Decomposition ink. The use of nanoparticle binders improved the green part density and reduced the sintering shrinkage, which has led to an improved sintered density when high binder saturation ratios were …
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Mechanisms of polymer adsorption in nanoparticle stabilization for poorly water soluble compounds
<p>In this dissertation, the mechanisms of nanosuspension stabilization via polymer adsorption on nanoparticle surface were investigated. As the electrokinetic behavior and colloidal stability depend on the surface characteristics, altering the surface adsorbed polymers affords the different …
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Investigation of Enhancement of Furosemide Solubilization with Cyclodextrins and a Novel Octenyl Succinate Anhydride Starch
… reduction, lipid based drug delivery systems, nanosuspension, use of surfactants, salt formation, cyclodextrin complexes and solid dispersion etc.</p> <p>Chapter 1 is an introduction into biopharmaceutics classification system (BCS) and novel drug solubilization techniques. It provides a brief …
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Drug nanosizing using microfluidic reactors. Development, characterisation and evaluation of corticosteroids nano-sized particles for optimised drug delivery.
… the potential of preparing pharmaceutical nanosuspensions using microfluidic reactors was researched. A hydrocortisone (HC) nanosuspension (NS) was prepared by introducing the generated drug particles into an aqueous solution of stabilizers stirred at high speed with a propeller mixer. A …
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Materiali Ceramici per Edilizia con Funzionalità Fotocatalitica
… and anatase/rutile ratio and a titania nanosuspension as well. The titania addition followed two procedures: bulk and spray addition over the ceramic samples surface. Titania was added in two different percentages: 2.5 and 7.5 wt.% in both of the methods. The ceramic samples were then …
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Batch and continuous production of stable dense suspensions of drug nanoparticles in a wet stirred media mill
… formation and physical stabilization of the nanosuspension with the use of polymers and surfactants (formulation parameters), understanding the impact of process parameters in the context of first-principle-based models, and production of truly nanosized drug particles (10-100 nm) with …
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NANOSUSPENSIONS-BASED ORAL DELIVERY PLATFORMS - NANODPS
In questa tesi di dottorato è stato studiato il potenziale delle nanosospensioni (NS) come intermedi di produzione per il miglioramento della solubilità e, di conseguenza, della biodisponibilità orale di farmaci scarsamente solubili in acqua, attraverso lo sviluppo di approcci tecnologici per la …