Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"nanoscale imaging"”.
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Nanoscale imaging and characterisation of Amyloid-β
… are not always immediately suitable for imaging delicate samples of proteins and adaptions must be made before imaging can be considered successful. AD is the most common form of dementia worldwide, and a growing concern for health authorities. As a result it has attracted the attention …
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Expansion microscopy : scalable and multiplexed nanoscale imaging
… allowing for unprecedented super-resolution imaging in thick tissues and facile reagent diffusion into the sample. We have since developed a variant of ExM, called protein retention ExM, in which proteins are directly anchored to the swellable gel using a commercially available cross-linking …
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Nanoscale imaging of MXenes by X-ray microscopy
… as the redox behavior of MXene flakes at the nanoscale. The thesis reveals that intercalants and surface terminations such as O, OH, and F play a significant role in the thermal stability and redox reactions of MXenes, with O-terminated surfaces being active sites for redox reactions. These …
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Model mismatch paradigm for probe based nanoscale imaging.
… properties and manipulation of matter at the nanoscale. These instruments are considered critical enablers of nanotechnology by providing the only technique for "direct" observation of dynamics at the nanoscale and affecting it with sub Angstrom resolution. Current SPMs are limited by low …
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Expansion microscopy of C. elegans : nanoscale imaging of biomolecules throughout an entire organism
Expansion microscopy (ExM) enables 3-D, nanoscale-precise imaging of biological specimens by isotropic swelling of hydrogel-embedded, chemically processed tissue. Such capability raises the question of whether nanoscale mapping of biomolecules could be performed in an entire organism, which would …
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Nanoscale biomolecular mapping in cells and tissues with expansion microscopy
… molecular organization of cells and tissues with nanoscale precision would open the door to understanding their biological functions as well as the mechanisms that lead to pathologies. Though recent technological advances have expanded the repertoire of biological tools, this crucial ability …
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Expansion Microscopy of Cells in Suspension
… is a laboratory technique that enables nanoscale imaging of biological samples with conventional light microscopes. While expansion microscopy has traditionally been applied to specimens consisting of tissue and adherent cell culture, it has not been optimized for specimens consisting of …
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Chemical functionalization of AFM cantilevers
… has been a powerful instrument that provides nanoscale imaging of surface features, mainly of rigid metal or ceramic surfaces that can be insulators as well as conductors. Since it has been demonstrated that AFM could be used in aqueous environment such as in water or various buffers from …
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Physics-assisted machine learning for X-ray imaging
X-ray imaging is capable of imaging the interior of objects in two and three dimensions non-invasively, with applications in biomedical imaging, materials study, electronic inspection, and other fields. The reconstruction process can be an ill-conditioned inverse problem, requiring regularization …
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Development of Atomic Force Microscopy Modalities Using Dissipation Signal for Enhancing the Sensitivity of Photo-Induced Force Detection
Nanoscale imaging and spectroscopy are crucial characterization methods as semiconductor devices shrink down to a few nanometers and below. Obtaining material property and topography images with a spatial resolution on this scale is achievable on several advanced characterization tools. Here we …
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Scanning tunneling microscopy and spectroscopy of topological materials with broken symmetry
… in thin films of (Bi1-xSbx)2Te3. By combining nanoscale imaging and spectroscopy, the sensitivity of the chemical potential to the chemical composition and thin film growth conditions was studied. The results demonstrate the multi-dimensional parameter space required to obtain an intrinsic …
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Imaging Nanoscale Spin Textures with Scanning Diamond Quantum Microscopy
… like drug delivery and magnetic resonance imaging. Their research and development have progressed towards ever-reducing spatial and magnetic footprints, largely motivated by promising novel properties emerging at reduced dimensions and the miniaturization of technology. Sustained research …
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Design and Control of Versatile High-Speed and Large-Range Atomic Force Microscopes
… are important in nano-technology research for imaging of nanoscale phenomena. Among such tools is the atomic force microscope (AFM) for nanoscale imaging and surface characterization. An AFM scans a micro-cantilever over the sample surface to measure various quantities from the probe-sample …
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Nanoscale magnetometry with a microcontroller-based magnetometer using a single nitrogen-vacancy defect in nanodiamond
… of around 4 mT/s. This system was used for nanoimaging the inhomogeneous spatial magnetic field profile of a magnetized steel microwire, and a spatial magnetic field gradient of 13 µT/63 nm was measured. Besides, its usefulness in nanoscale imaging of magnetic fields, the present work can be of …
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Expansion Microscopy of Extracellular Space for Light Microscopy-Based Connectomic Analysis
… microscopy (ExM), a method that facilitates nanoscale imaging on conventional microscopes through physical magnification of specimens, thereby supporting improved visualization of various cellular and tissue components including proteins, nucleic acids, and lipids 1. The ECS forms a …
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A new dynamic mode for fast imaging in atomic force microscopes
Video-rate imaging and property sensing with nanoscale precision is a subject of immense interest to scientists because it facilitates a deep understanding of processes and sample properties at a molecular level. This dissertation addresses the challenges of high-bandwidth imaging and real-time …
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Label-Free Functional Imaging Of Platelets At Nanoscale
… last few decades, the development of advanced imaging tools (optical, electrons, conductance, and atomic force) have revealed a highly heterogeneous distribution of platelet morphologies at the microscopic scale that spreads across a thrombus. Under platelet spreading assays, the membrane …
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Label-Free Functional Imaging Of Platelets At Nanoscale
… last few decades, the development of advanced imaging tools (optical, electrons, conductance, and atomic force) have revealed a highly heterogeneous distribution of platelet morphologies at the microscopic scale that spreads across a thrombus. Under platelet spreading assays, the membrane …
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A modular atomic force microscope for nanotechnology research
… instrument, which has enabled new insights into nanoscale phenomena. Despite decades of research, state-of-the-art AFMs are not widely utilized. In order to accelerate the proliferation and development of these instruments, a modular atomic force microscope is presented. The optical, mechanical, …
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Multi-scale Assessment of Bone Mechanics and the Mineral Phase of Intramuscular Bone of Atlantic Herring Fish
<p>Bone tissue is a complex composite structure made up of a soft organic phase consisting of collagen I and non-collagenous proteins, and a hard inorganic phase consisting of mineral nanoplatelets. Given it’s compositional properties, bone is a unique stiff, tough, and strong biomaterial, making …