Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"nanoprecipitation"”.
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Design and modelling of ultra-high strength steels: nanoprecipitation and plasticity
… to develop new ultra-high strength steels via nanoprecipitation control, which requires an understanding of the processing-microstructure-property relationship in medium carbon (0.5-0.6 wt.%) steels throughout tempering. Much of the work has been centred in understanding the role of silicon at …
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Consistent Fabrication of Ultrasmall PLGA Nanoparticles and their Potential Biomedical Applications
… nanoparticles (PLGA NPs) using a quick and easy nanoprecipitation method1, with some modifications, for general use in various biomedical areas. Nanoprecipitation of two solutions – PLGA dissolved in acetonitrile and aqueous poly(vinyl alcohol) (PVA) – at varying concentrations produced …
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Drug nanosizing using microfluidic reactors. Development, characterisation and evaluation of corticosteroids nano-sized particles for optimised drug delivery.
… and budesonide). Arrested antisolvent nanoprecipitation using ethanol (solvent) and water (antisolvent) was conducted within the microreactors. To enable experimental design for the microreactor studies, solubility profiles in different ethanol-water combinations at 25 °C were explored. …
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Preparation of multifunctional nanoparticles using microfluidics
… were prepared by microfluidic-assisted nanoprecipitation. The effect of processing and formulation parameters were studied, and the physicochemical properties of the prepared liposomes were determined. It was shown that the processing parameters: total flow rate (TFR), and …
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Transport properties of synthetic nanopores
… phenomenon reported in nanopores, so called nanoprecipitation oscillations. The simulations unveiled the atomic detail mechanism of the nanoprecipitation phenomenon.
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Characterization of mixing in a coaxial jet mixer for nanoparticle fabrication
… nanoparticle production over conventional bulk nanoprecipitation methods. Mixing time was determined based on photographs of mixing of an acidic solution and a basic solution in the device, with phenolphtalein used as an indicator of the extent of mixing. The average Reynolds number and velocity …
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Development and Characterization of Controlled Drug Delivery Using Nanoparticles
… glycolide) (PLGA) nanoparticles by simple nanoprecipitation method. The small size of these particles (<200nm) could be beneficial to realize passive tumor-targeted drug delivery through enhanced permeability and retention (EPR) effects. These drug-containing particles showed a sustained …
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Design, Development, and Study of New High-Throughput Biodegradation Test for Polymers
… a new sample preparation process using polymer nanoprecipitation, the system enables the determination of biodegradation rates. Finally, the development of a kinetic model capable of reproducing clear-zone assay results is developed, thus allowing to relate biodegradation rate with kinetic rates.
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Synthesis and Characterization of Multi-Functional Nanoparticles for Therapeutic and Biosensing Applications
… by single emulsion solvent evaporation and nanoprecipitation. The encapsulation efficiency of OSI-420 increased using the nanoprecipitation method while that of AZD9291 was increased using the single emulsion solvent evaporation method. Preliminary encapsulated OSI-420 and AZD9291 did not …
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Nanostructuring of Cu-TiB2 induced by ion irradiation
… to 650 °C. It is thus concluded that this nanoprecipitation takes place in displacement cascades.
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Design, Synthesis, and Characterization of Magnetite Clusters using a Multi Inlet Vortex Mixer
… and control of size distributions using flash nanoprecipitation. First, the mixer was tested using β-carotene as a model compound to form nanoparticles stabilized with an amphiphilic triblock copolymer poly(propylene oxide)-b-poly(ethylene oxide) (F127) at different Reynolds numbers and …
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Nanoparticles Targeting at Inflammation Site
… PEG-PCL-NanoPaz-t, produced via flash nanoprecipitation followed by spray drying. This scalable approach achieved over a 9,000-fold increase in production rate and maintained the therapeutic efficacy of pazopanib in a canine OA model, demonstrating extended pain relief and improved drug …
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Small Solutions to Big Problems: Design and Synthesis of Nanoparticles for Biomedical Applications
… the knowledge gap regarding the use of flash nanoprecipitation (FNP) for nanoparticle synthesis. FNP is a scalable nanoparticle fabrication method that produces small, well-defined nanoparticle populations through rapid, turbulent mixing of multiple solvent streams. This work elucidates …
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Synthesis and Characterization of Poly(lactide) Functional Oligomers and Block Copolymers
… and size distributions were fabricated by rapid nanoprecipitation using blends of the PEO-b-PDLLA block copolymer with poly(L-lactide), (PLLA) homopolymer. Heterobifunctional PEO oligomers were directly prepared by initiating ethylene oxide with functional alcohols bearing vinylsilane, vinylether …
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Fighting cancer with nanomedicine−drug-polyester nanoconjugates for targeted cancer therapy
… ring opening polymerization (ROP) with nanoprecipitation technique, I successfully developed a polymeric NC system based on poly(lactic acid) and poly(O-carboxyanhydrides) (OCA) that allows for the quantitative loading and controlled release of a variety of anticancer drugs. The …
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Zein-based nanoparticles for drug delivery applications
… could be obtained using the conventional nanoprecipitation method. Overall, this thesis demonstrated that PEGylated zein micelles are highly promising delivery systems that should be further investigated for use in cancer drug delivery.
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Novel Paclitaxel Nanoparticles for Enhanced Therapeutic Effects in Breast Cancer
… safe and efficacious nanoparticle formulation by nanoprecipitation technique. For this, we screened commonly used pharmaceutical excipients and polymers and found the best candidate with built-in chemosensitization motifs (tannic acid: TA) and polyvinyl/pyrrolidone (PVP), given their innate …
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Identificazione di bersagli terapeutici e realizzazione di tecnologie innovative in oncologia ortopedica
… was to obtain osteotropic biodegradable NP by nanoprecipitation of a copolymer between poly(D,L-lactide-co-glycolide) (PLGA) and an osteotropic bisphosphonate, sodium alendronate (ALE). NP were subsequently characterised for their chemical-physical properties, biocompatibility, and the ability …
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Antioxidant Nanoparticles as Delivery Systems
… and PLGA-EC nanoparticles were made by nanoprecipitation, and the nanoparticle physical properties were studied at different salt concentrations, surfactant concentrations, and polymer:surfactant ratios. EC was soluble in polar solvents, and Span 80 was selected as a control due to its …
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Reactive Oxygen Species (ROS) Triggered Delivery System for the Treatment of Diabetic Retinopathy
… were prepared from Ox-β-cyclodextrin by nanoprecipitation. The size of the nanoparticles and the surface charge was found to in the range of 230 to 295 nm and -15 to -20 mV, respectively. An LC-MS/MS-based analytical method was developed to quantify both drugs simultaneously in aqueous …
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