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Showing 1 to 7 of 7 for “"nanoparticle vaccine"”.
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Development of a Nanoparticle Vaccine Delivery System with Polymeric Oral Adjuvants for Poultry
… of protective immunity using different vaccine delivery methods. A vaccine delivery system using oral adjuvants would be applicable across species for both individual and mass vaccination in both the medical and veterinary fields. We sought to create an oral nanoparticle (NP) vaccine …
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Development of polymeric nanoparticle vaccines for immunostimulation
Vaccines have revolutionized medicine by increasing the life expectancy of children and substantially decreasing the morbidity of multiple infectious diseases worldwide. Over several decades, we have acquired significant gains in the understanding of the underlying mechanisms involved in developing …
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Engineering Nanoparticulate Antigens for Enhanced Follicular Accumulation and Immunogenicity
In vaccine design, antigens are often arrayed in a multivalent nanoparticle form, but in vivo mechanisms underlying the enhanced immunity elicited by such vaccines remain poorly understood. In this thesis, we began by examining two model, HIV-immunogen-bearing nanoparticles that displayed an …
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Surface Engineering of Protein Nanoparticles for Intranasal Delivery
Intranasal delivery of vaccines offers a promising alternative approach to invasive intramuscular injection, with additional benefits such as inducing mucosal antibodies and cellular responses to neutralize pathogens before entering systemic circulation. However, nasal secretions and mucosa are …
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Evaluation of Highly Conserved Burkholderia pseudomallei Proteins as pan-Burkholderia Vaccine Antigen Candidates
… history of use as a biothreat agent. Numerous vaccine candidates to these B. pseudomallei complex species have been developed over the years, though none are currently approved for use in humans. On the other hand, the B. cepacia complex consists of >20 closely related species, many of which …
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Investigation of Novel Prophylactics Against Human Rotavirus Using Gnotobiotic Pig Models
… each year. There are two live oral attenuated vaccines licensed for use in the United States that are highly effective in high-income countries but much less so in low-and middle-income countries (LMICs). Several factors contributing to decreased efficacy in these areas include chronic …
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Cooperativity: Physiologic Cornerstone and Emerging Therapeutic Design Principle
The content of this work is based on the previously published articles that are cited below.